Kaempferol

Catalog No.S2314 Synonyms: Robigenin

Kaempferol Chemical Structure

Molecular Weight(MW): 286.23

Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

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1 Customer Review

  • Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).

    Food Funct, 2015, 6(8):2824-33. Kaempferol purchased from Selleck.

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Biological Activity

Description Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Targets
ERRα [1] ERRγ [1] Topo I [2] fatty acid synthase [3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 FS cells MWjGeY5kfGmxbjDhd5NigQ>? MWfJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTFwMjFOwG0> NIe1SlYzODd|MUO1Oy=>
human HeLa cells NX71XZdJTnWwY4Tpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKE2UUEGgeJJidnOoZXP0[YQhcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFt|SG3MWGM1KHS{YX7zdI9zfCCkeTDyZZBq\CCoaXz0doF1cW:wIHHzd4F6NCCNaU2yMlQh|ryP MnLZNVk4OjV3N{i=
human MV4-11 cells Ml\nR5l1d3SxeHnjbZR6KGG|c3H5 MUC3NkBp M324c2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1XPC1zMTDj[YxteyCqYYLic5JqdmdiRlzUN{BufXSjdHnvckBi\nSncjC3NkBpenNiYomgeIV1emG8b3zpeY0h[mG|ZXSgSZohS3mWb4igZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUC9N{4{PCEQvF2= NHfYToQzOzRzMUC3Ny=>
MDCK cells NFf0[lZHfW6ldHnvckBie3OjeR?= NH[5c5JKdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKGmwIF3ER2sh[2WubIOgeZNqdmdiSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{whUUN3ME20Mlch|ryP NXTLd5g5OjF|NUS4NFA>
human MDA-kb2 cells NVX6PJIxTnWwY4Tpc44h[XO|YYm= NHHC[4RCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHHu[JJw\2WwIILlZ4VxfG:{IHnuJIh2dWGwIF3ERU1s[jJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBFUFRvaX7keYNm\CCudXPp[oVz[XOnIHHjeIl3cXS7IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NF06NjdizszN MnrpNVk2QTJ{NEW=
B16-4A5 cells MoLaSpVv[3Srb36gZZN{[Xl? MW\Jcohq[mm2aX;uJI9nKG2nbHHuc4dmdmW|aYOgbY4hfGinb4DofYxtcW6nLYP0bY12dGG2ZXSgcY92e2ViQkG2MVRCPSClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OjBizszN NXzsdGVLOTl4MUW5NVA>
human HL60 cells MnLtR5l1d3SxeHnjbZR6KGG|c3H5 MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygd5Vzfmm4YXygZZQhPTBidV2gZYZ1\XJiN{KgbJJ{KGK7IFPDT|gh[XO|YYm= NUXxS4MzOjVyN{S4NVU>
mouse 3T3L1 cells M{TpTGZ2dmO2aX;uJIF{e2G7 NFHJPHFKdmirYnn0bY9vKG:oIFHNVGsudWWmaXH0[YQh[WSrcH;jfZRmKGSrZn\ldoVvfGmjdHnvckBqdiCvb4Xz[UA{XDOOMTDj[Yxtew>? NXvEflNJOjB6MkK5NFI>
mouse RAW264.7 cells M2TtPWZ2dmO2aX;uJIF{e2G7 M3nkcmFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hVFCVLYP0bY12dGG2ZXSgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNibnn0dol1\SCuZY\lcEBifCBzIITvJFExOCC3TTDh[pRmeiB{NDDodpMh[nliR4Lp[ZN{KG2ndHjv[C=> Mo[yNlE{PTN3NEO=
mouse L929 cells NFnhfmZHfW6ldHnvckBie3OjeR?= MknvTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCWTl[tZYxxcGFvaX7keYNm\CCleYTveI95cWOrdImgc4YhdW:3c3WgUFkzQSClZXzsd{Bie3Onc4Pl[EBieyC|dYL2bZZidGm2eTD0doVifGWmIIfpeIgh\HK3ZzDh[pRmeiB{IHjyd{Bw\iCWTl\hcJBp[SC2cnXheI1mdnR? NWjXXI1ZQTJ6N{SxOS=>
human U87 cells NULQ[29wS3m2b4TvfIlkcXS7IHHzd4F6 NFvJO4M2NTRyIN88US=> MmHlO|IhcA>? NIXw[FdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQDdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHH0JFUhfG9iNECgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> Mn3RNlI5PzF{MUe=
human A549 cells NEj2OodEgXSxdH;4bYNqfHliYYPzZZk> NUTaVXV4PS12MDFOwG0> MnTzO|IhcA>? MormR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYYSgOUB1dyB2MDD1UUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5 NUH6SWUyOjJ6N{GyNVc>
human MCF7 cells MUjDfZRwfG:6aXPpeJkh[XO|YYm= MkGyOU01OCEQvF2= MlfEO|IhcA>? NIXrfIREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDheEA2KHSxIESwJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZk> NIXKcWIzOjh5MUKxOy=>
MDA-MB-231 cells M17FemN6fG:2b4jpZ4l1gSCjc4PhfS=> Mm\zOU01OCEQvF2= M2HDfVczKGh? NH2wRZVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjdDC1JJRwKDRyIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= NVvPOIQ3OjJ6N{GyNVc>
MDCK cells MnzVSpVv[3Srb36gZZN{[Xl? NFjrb2g2OCEQvF2= MWXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDpcoZtfWWwenGgRUB3cXK3czDINW4yKEFxUGKvPE8{PCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDmcJVwemW|Y3XuZ4UheG:|aYTpeoUh[2WubIOgZZQhPTBidV2gbY1ufW6xZnz1c5Jme2OnbnPlJIF{e2G7 MlvWNVk4Ojl|MU[=
human NCI-H2126 cells NFPsPWhEgXSxdH;4bYNqfHliYYPzZZk> MWS1MVQxKM7:TR?= MYe3NkBp NW[wc2d5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVkOLLViyNVI3KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjdDC1JJRwKDRyIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= NFfGcHgzOjh5MUKxOy=>
human SMMC7721 cells NFPBT25EgXSxdH;4bYNqfHliYYPzZZk> M{mxelUuPDBizszN NVLnOI9DPzJiaB?= NH7D[lZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVU2FN{eyNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[XRiNTD0c{A1OCC3TTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7 M17J[FIzQDdzMkG3
human PANC1 cells NWT4TVZ2S3m2b4TvfIlkcXS7IHHzd4F6 NIHpZpA2NTRyIN88US=> MoXBO|IhcA>? NETkZVZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSU6FMTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 NF;RclgzOjh5MUKxOy=>
human BxPC3 cells M4\zSWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4SyNFUuPDBizszN NHLLRpM4OiCq NEXtdGdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDgFCFMzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 MUeyNlg4OTJzNx?=

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Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL warmed (199.14 mM)
Ethanol 3 mg/mL (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.23
Formula

C15H10O6

CAS No. 520-18-3
Storage powder
Synonyms Robigenin

Bio Calculators

Molarity Calculator

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID