Home Endocrinology & Hormones Estrogen/progestogen Receptor modulator - Fatty Acid Synthase inhibitor Kaempferol For research use only.

Kaempferol

Synonyms: NSC 407289, Robigenin

Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

Kaempferol Chemical Structure

Kaempferol Chemical Structure

CAS: 520-18-3

Selleck's Kaempferol has been cited by 19 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 99.86%
99.86

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Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathways

Estrogen/progestogen Receptor Signaling Pathway

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Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 FS cells Function assay Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=1.2 μM 20731357
human HeLa cells Function assay Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay, Ki=2.4 μM 19725578
human MV4-11 cells Cytotoxicity assay 72 h Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay, GI50=3.34 μM 23411073
MDCK cells Function assay Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining, IC50=4.7 μM 21354800
human MDA-kb2 cells Function assay Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene assay, IC50=9.7 μM 19592245
B16-4A5 cells Function assay Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs, IC50=20 μM 19615910
human HL60 cells Cytotoxicity assay Cytotoxicity against human HL60 cells assessed as cell survival at 50 uM after 72 hrs by CCK8 assay 25074815
mouse 3T3L1 cells Function assay Inhibition of AMPK-mediated adipocyte differentiation in mouse 3T3L1 cells 20822902
mouse RAW264.7 cells Function assay Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as nitrite level at 1 to 100 uM after 24 hrs by Griess method 21353543
mouse L929 cells Function assay Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment 9287415
human U87 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human U87 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human A549 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human A549 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human MCF7 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
MDA-MB-231 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
MDCK cells Function assay 50 μM Antiviral activity against influenza A virus H1N1 A/PR/8/34 infected in MDCK cells assessed as reduction in fluorescence positive cells at 50 uM immunofluorescence assay 19729316
human NCI-H2126 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human NCI-H2126 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human SMMC7721 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human PANC1 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human PANC1 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
human BxPC3 cells Cytotoxicity assay 5-40 μM 72 h Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay 22871217
Click to View More Cell Line Experimental Data

Biological Activity

Description Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Targets
ERRα [1] ERRγ [1] Topo I [2] fatty acid synthase [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05073523 Completed
Healthy
Chalmers University of Technology
 September 27 2021 Not Applicable

Chemical Information & Solubility

Molecular Weight 286.23 Formula

C15H10O6
CAS No. 520-18-3 SDF Download Kaempferol SDF
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 28 mg/mL

DMSO : 27 mg/mL ( (94.32 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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