Kaempferol

Catalog No.S2314 Synonyms: Robigenin

Kaempferol Chemical Structure

Molecular Weight(MW): 286.23

Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

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1 Customer Review

  • Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).

    Food Funct, 2015, 6(8):2824-33. Kaempferol purchased from Selleck.

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Biological Activity

Description Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Targets
ERRα [1] ERRγ [1] Topo I [2] fatty acid synthase [3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 FS cells M3TiVGZ2dmO2aX;uJIF{e2G7 NXf3XIZXUW6qaXLpeIlwdiCxZjDOU3g1KGW6cILld5Nm\CCrbjDISWszQTNiRmOgZ4VtdHNiYYPz[ZN{\WRiYYOgTFJQOiCycn;keYN1cW:wIHL5JGgzVzJxVInyM2xRVyCjc4PhfUwhUUN3ME2xMlIh|ryP MUSyNFc{OTN3Nx?=
human HeLa cells NGDtdG9HfW6ldHnvckBie3OjeR?= NWTHWGpmUW6qaXLpeIlwdiCxZjDNVnAyKHS{YX7z[oVkfGWmIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2heVFSFNDD0doFve3CxcoSgZpkhemGyaXSg[oltfHKjdHnvckBie3OjeTygT4k:Oi52IN88US=> Mmn0NVk4OjV3N{i=
human MV4-11 cells MmLOR5l1d3SxeHnjbZR6KGG|c3H5 NXS4dJBSPzJiaB?= M1n3dWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1XPC1zMTDj[YxteyCqYYLic5JqdmdiRlzUN{BufXSjdHnvckBi\nSncjC3NkBpenNiYomgeIV1emG8b3zpeY0h[mG|ZXSgSZohS3mWb4igZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUC9N{4{PCEQvF2= NXfMSIgxOjN2MUGwO|M>
MDCK cells MmTVSpVv[3Srb36gZZN{[Xl? MYHJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNidYPpcochUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzygTWM2OD12Lkeg{txO MnG2NlE{PTR6MEC=
human MDA-kb2 cells MX;GeY5kfGmxbjDhd5NigQ>? NFPERndCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHHu[JJw\2WwIILlZ4VxfG:{IHnuJIh2dWGwIF3ERU1s[jJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBFUFRvaX7keYNm\CCudXPp[oVz[XOnIHHjeIl3cXS7IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NF06NjdizszN MXGxPVU6OjJ2NR?=
B16-4A5 cells M{D4VWZ2dmO2aX;uJIF{e2G7 M1G4SGlvcGmkaYTpc44hd2ZibXXsZY5w\2WwZYPpd{BqdiC2aHXvdIh6dGyrbnWtd5RqdXWuYYTl[EBud3W|ZTDCNVYuPEF3IHPlcIx{KGGodHXyJFczKGi{czygTWM2OD1{MDFOwG0> Ml7nNVk3OTV7MUC=
human HL60 cells NFnqdlREgXSxdH;4bYNqfHliYYPzZZk> NHzqRnBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJVDZyIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhe3W{dnn2ZYwh[XRiNUCgeW0h[W[2ZYKgO|IhcHK|IHL5JGNEUzhiYYPzZZk> M3nBUlI2ODd2OEG1
mouse 3T3L1 cells M1nEVGZ2dmO2aX;uJIF{e2G7 M1HVdmlvcGmkaYTpc44hd2ZiQV3QT{1u\WSrYYTl[EBi\Gmyb3P5eIUh\GmoZnXy[Y51cWG2aX;uJIlvKG2xdYPlJFNVO0xzIHPlcIx{ MUKyNFgzOjlyMh?=
mouse RAW264.7 cells NXnRUVVNTnWwY4Tpc44h[XO|YYm= NUTWemVbSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCOUGOtd5RqdXWuYYTl[EBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDubZRzcXSnIHzleoVtKGG2IEGgeI8hOTByIIXNJIFnfGW{IEK0JIhzeyCkeTDHdolme3NibXX0bI9l MV:yNVM2OzV2Mx?=
mouse L929 cells NETyVHNHfW6ldHnvckBie3OjeR?= NFe5SGdKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGTOSk1idHCqYT3pcoR2[2WmIHP5eI91d3irY3n0fUBw\iCvb4Xz[UBNQTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IIP1dpZqfmGuaYT5JJRz\WG2ZXSge4l1cCCmcoXnJIFnfGW{IEKgbJJ{KG:oIGTOSoFteGijIITy[YF1dWWwdB?= MUS5Nlg4PDF3
human U87 cells NUTXdoN{S3m2b4TvfIlkcXS7IHHzd4F6 NXLJXohrPS12MDFOwG0> M3zmZlczKGh? M3nOVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU5PyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYYSgOUB1dyB2MDD1UUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5 M{PPNVIzQDdzMkG3
human A549 cells NFvDR4pEgXSxdH;4bYNqfHliYYPzZZk> NIrlUVI2NTRyIN88US=> M1jXSlczKGh? NYTLOYM6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 M2npOlIzQDdzMkG3
human MCF7 cells M3T3UGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2DB[VUuPDBizszN MlP4O|IhcA>? NULyOpMzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 NGrH[nczOjh5MUKxOy=>
MDA-MB-231 cells NFPyUmVEgXSxdH;4bYNqfHliYYPzZZk> Ml3mOU01OCEQvF2= M2i3OlczKGh? MkfoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[XRiNTD0c{A1OCC3TTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7 NYHyfZBMOjJ6N{GyNVc>
MDCK cells M1TvR2Z2dmO2aX;uJIF{e2G7 M1nrdVUxKM7:TR?= MlXnRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbY5ndHWnborhJGEhfmm{dYOgTFFPOSCDL2DSM|gwOzRiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6g[ox2d3Knc3PlcoNmKHCxc3n0bZZmKGOnbHzzJIF1KDVyIIXNJIludXWwb3\seY9z\XOlZX7j[UBie3OjeR?= M2D4[VE6PzJ7M{G2
human NCI-H2126 cells MkLzR5l1d3SxeHnjbZR6KGG|c3H5 Mn3QOU01OCEQvF2= NWLSd|J3PzJiaB?= MoDvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUmNKNUh{MUK2JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBifCB3IITvJFQxKHWPIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[Xl? Ml;LNlI5PzF{MUe=
human SMMC7721 cells NXn0dIMxS3m2b4TvfIlkcXS7IHHzd4F6 MV21MVQxKM7:TR?= MUS3NkBp MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 NHPwZWczOjh5MUKxOy=>
human PANC1 cells MY\DfZRwfG:6aXPpeJkh[XO|YYm= NF2zcZA2NTRyIN88US=> MXS3NkBp NIq0W2tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSU6FMTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 NW\2U2dSOjJ6N{GyNVc>
human BxPC3 cells MmT1R5l1d3SxeHnjbZR6KGG|c3H5 MWO1MVQxKM7:TR?= NEDpWmE4OiCq NFTDcoFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDgFCFMzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 MYmyNlg4OTJzNx?=

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Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL warmed (199.14 mM)
Ethanol 3 mg/mL (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.23
Formula

C15H10O6

CAS No. 520-18-3
Storage powder
Synonyms Robigenin

Bio Calculators

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID