Kaempferol

Catalog No.S2314 Synonyms: Robigenin

Kaempferol Chemical Structure

Molecular Weight(MW): 286.23

Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

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1 Customer Review

  • Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).

    Food Funct, 2015, 6(8):2824-33. Kaempferol purchased from Selleck.

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Biological Activity

Description Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Targets
ERRα [1] ERRγ [1] Topo I [2] fatty acid synthase [3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 FS cells M4LwXmZ2dmO2aX;uJIF{e2G7 M2fsZWlvcGmkaYTpc44hd2ZiTl;YOEBmgHC{ZYPz[YQhcW5iSFXLNlk{KE[VIHPlcIx{KGG|c3Xzd4VlKGG|IFiyU|IheHKxZIXjeIlwdiCkeTDINm8zN1S7cj;MVG8h[XO|YYmsJGlEPTB;MT6yJO69VQ>? Ml7wNlA4OzF|NUe=
human HeLa cells NF\SOldHfW6ldHnvckBie3OjeR?= NVjvWIJLUW6qaXLpeIlwdiCxZjDNVnAyKHS{YX7z[oVkfGWmIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2heVFSFNDD0doFve3CxcoSgZpkhemGyaXSg[oltfHKjdHnvckBie3OjeTygT4k:Oi52IN88US=> M4HmfVE6PzJ3NUe4
human MV4-11 cells NUfzRYV{S3m2b4TvfIlkcXS7IHHzd4F6 M1fHVVczKGh? Ml3TR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXY1NTFzIHPlcIx{KGijcnLvdolv\yCITGSzJI12fGG2aX;uJIFnfGW{IEeyJIhzeyCkeTD0[ZRz[XqxbHn1cUBj[XOnZDDFfkBEgVSxeDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3ME2zMlM1KM7:TR?= MmnoNlM1OTFyN{O=
MDCK cells NUjZO|ZyTnWwY4Tpc44h[XO|YYm= MmPxTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy|IIXzbY5oKEixZXPod5QhOzN|NEKgd5RicW6rbnesJGlEPTB;ND63JO69VQ>? NWq0eZl2OjF|NUS4NFA>
human MDA-kb2 cells MmG1SpVv[3Srb36gZZN{[Xl? MnLHRY51[WexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCPRFGtb4IzKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gSGhVNWmwZIXj[YQhdHWlaX\ldoF{\SCjY4Tpeol1gSCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9PU44KM7:TR?= NHHuOY0yQTV7MkK0OS=>
B16-4A5 cells NIDsSoVHfW6ldHnvckBie3OjeR?= MULJcohq[mm2aX;uJI9nKG2nbHHuc4dmdmW|aYOgbY4hfGinb4DofYxtcW6nLYP0bY12dGG2ZXSgcY92e2ViQkG2MVRCPSClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OjBizszN M1TiNFE6PjF3OUGw
human HL60 cells MXjDfZRwfG:6aXPpeJkh[XO|YYm= Mki1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGw3OCClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJN2en[rdnHsJIF1KDVyIIXNJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5 NH\IO|gzPTB5NEixOS=>
mouse 3T3L1 cells M{i1ZWZ2dmO2aX;uJIF{e2G7 Ml\LTY5pcWKrdHnvckBw\iCDTWDLMY1m\GmjdHXkJIFlcXCxY4n0[UBlcW[oZYLlcpRq[XSrb36gbY4hdW:3c3WgN3Q{VDFiY3XscJM> NHS4U2szODh{MkmwNi=>
mouse RAW264.7 cells MlTmSpVv[3Srb36gZZN{[Xl? NGLaSm1CdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKEySUz3zeIlufWyjdHXkJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IH7peJJqfGVibHX2[Ywh[XRiMTD0c{AyODBidV2gZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCvZYToc4Q> MWOyNVM2OzV2Mx?=
mouse L929 cells MWHGeY5kfGmxbjDhd5NigQ>? NG\uemFKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGTOSk1idHCqYT3pcoR2[2WmIHP5eI91d3irY3n0fUBw\iCvb4Xz[UBNQTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IIP1dpZqfmGuaYT5JJRz\WG2ZXSge4l1cCCmcoXnJIFnfGW{IEKgbJJ{KG:oIGTOSoFteGijIITy[YF1dWWwdB?= NWKxV|l3QTJ6N{SxOS=>
human U87 cells NF7xU|lEgXSxdH;4bYNqfHliYYPzZZk> NVfjUlN1PS12MDFOwG0> M371d|czKGh? NF3YeYVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQDdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHH0JFUhfG9iNECgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> NELsPWQzOjh5MUKxOy=>
human A549 cells MYfDfZRwfG:6aXPpeJkh[XO|YYm= NHnFOJE2NTRyIN88US=> NVr5V2xNPzJiaB?= M1noc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHH0JFUhfG9iNECgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> MXmyNlg4OTJzNx?=
human MCF7 cells MVzDfZRwfG:6aXPpeJkh[XO|YYm= MkO3OU01OCEQvF2= M1nVdFczKGh? NUH2OnIyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 NEDrfGwzOjh5MUKxOy=>
MDA-MB-231 cells NW\qdmxRS3m2b4TvfIlkcXS7IHHzd4F6 NGi5co42NTRyIN88US=> Mlr3O|IhcA>? MmLsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[XRiNTD0c{A1OCC3TTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7 M2L1cFIzQDdzMkG3
MDCK cells M3\ucmZ2dmO2aX;uJIF{e2G7 MVi1NEDPxE1? Ml\QRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgbY5ndHWnborhJGEhfmm{dYOgTFFPOSCDL2DSM|gwOzRiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6g[ox2d3Knc3PlcoNmKHCxc3n0bZZmKGOnbHzzJIF1KDVyIIXNJIludXWwb3\seY9z\XOlZX7j[UBie3OjeR?= NXS0fZdTOTl5MkmzNVY>
human NCI-H2126 cells MVHDfZRwfG:6aXPpeJkh[XO|YYm= MWe1MVQxKM7:TR?= NYn5ZlY5PzJiaB?= MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDJzMk[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIF1KDVidH:gOFAhfU1iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigQ>? MorUNlI5PzF{MUe=
human SMMC7721 cells MVTDfZRwfG:6aXPpeJkh[XO|YYm= NHnkN2I2NTRyIN88US=> NUXLXY9GPzJiaB?= M3fFe2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNOVUN5N{KxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBifCB3IITvJFQxKHWPIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[Xl? MmjrNlI5PzF{MUe=
human PANC1 cells Mn;4R5l1d3SxeHnjbZR6KGG|c3H5 NEPGOpI2NTRyIN88US=> MoHNO|IhcA>? NWPYU3B[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIF1KDVidH:gOFAhfU1iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigQ>? M2nZdFIzQDdzMkG3
human BxPC3 cells M1PDbGN6fG:2b4jpZ4l1gSCjc4PhfS=> NF35ToY2NTRyIN88US=> NH7IWIY4OiCq NGjVcHhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDgFCFMzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 Mk[1NlI5PzF{MUe=

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Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL warmed (199.14 mM)
Ethanol 3 mg/mL (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.23
Formula

C15H10O6

CAS No. 520-18-3
Storage powder
in solvent
Synonyms Robigenin

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID