Bisdemethoxycurcumin (BDMC)

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.

Bisdemethoxycurcumin (BDMC) Chemical Structure

Bisdemethoxycurcumin (BDMC) Chemical Structure

CAS: 33171-05-0

Selleck's Bisdemethoxycurcumin (BDMC) has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.86%
99.86

Bisdemethoxycurcumin (BDMC) Related Products

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Biological Activity

Description Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.
In vitro
In vitro Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin, which is a natural substance found in the turmeric root. BDMC inhibits the growth of gastric cancer SGC 7901 cells in a dose‑dependent manner. BDMC arrests the cell growth in G1 phase and thus, cells could not reach S phase and complete the cycle[2].
Cell Research Cell lines The NSCLC cell lines A549, H460 and SPC-A-1
Concentrations 0-100 μM
Incubation Time 72 h
Method

The cells are grown at 37˚C in a humidified atmosphere of 5% CO2. To evaluate the hypomethylation effect of bisdemethoxycurcumin, DAC is used as positive control. Curcumin, DMC, BDMC and DAC are prepared as stock solutions (20 mM) in dimethyl sulfoxide (DMSO) and diluted in sterile-filtered media before use. Cells (1×105) are seeded into 6-well culture plates. After 24 h of culture, the cells are treated with curcumin, DMC, BDMC (0-100 μM) or DAC (20 μM) for 72 h.

In Vivo
In vivo BDMC may promote apoptosis in tumors via mitochondrial modulation. BDMC inhibits the tumor growth and caused an increase in body weight of gastric adenoadenocarcinoma xenograft model[2].
Animal Research Animal Models human gastric adenoadenocarcinoma xenograft model (nude mice)
Dosages 100 mg/kg/day
Administration s.c.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05542394 Completed
Plasma Levels of Different Curcuminoids Preparations
University of Jordan|Nutritional Fundamentals for Health
September 20 2022 Not Applicable
NCT01982734 Completed
Pharmacokinetics of New Curcumin Formulations|Safety of New Curcumin Formulations
University of Hohenheim|German Federal Ministry of Education and Research
November 2012 Early Phase 1
NCT01925287 Completed
Pharmacokinetics of Novel Curcumin Formulations|Safety of Novel Curcumin Formulations
University of Hohenheim|German Federal Ministry of Education and Research
October 2011 Early Phase 1

Chemical Information & Solubility

Molecular Weight 308.33 Formula

C19H16O4

CAS No. 33171-05-0 SDF Download Bisdemethoxycurcumin (BDMC) SDF
Smiles C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (201.08 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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