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Carvacrol AChR inhibitor

Name: Carvacrol
Brand: Selleck Chemicals
SKU: S3788
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3788

Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, antimutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.

Chemical Structure

Molecular Weight: 150.22

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Quality Control

Batch: Purity: 99.87%

99.87

Related Targets	Adrenergic Receptor 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other AChR Inhibitors	PNU-120596 Benzethonium Chloride Arecoline HBr Otilonium Bromide Lycorine Hyoscyamine (-)-Huperzine A (HupA) Nitenpyram Cytisine Chelidonine

Solubility

In vitro
Batch:

DMSO : 30 mg/mL (199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 30 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.500mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 30 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.500mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 30 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	150.22	Formula	C₁₀H₁₄O	Storage (From the date of receipt)	2 years -20°C liquid
CAS No.	499-75-2	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

In vitro	Carvacrol (CVC) possesses weak antioxidant and cytotoxic activity in cultured primary rat neurons. In addition, this compound has weak antioxidant properties and little anticancer potentials in rat N2a neuroblastoma cell line. It is a novel inhibitor of transient receptor potential (TRP) channels in drosophila and mammalian. In human hepatoma HepG2 cells, this chemical induces cell apoptosis by selectively decreasing phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and P38; In human macrophage-like U937 cells, in response to lipopolysaccharide treatment, it activates peroxisome proliferator-activated receptors (PPAR alpha and gamma) and suppresses cyclooxygenase-2 (COX-2) mRNA and protein expression.
In vivo	Carvacrol has the ability to protect liver against ischemia/reperfusion injury in rats. In the central nervous system, this compound is regarded as a potential drug for Alzheimer's disease due to its inhibitory effect on acetylcholinesterase (AChE) activity by using phenolic hydroxyl group of carvacrol to bind to AChE and leading to a loss of function of AChE. In addition, it is found to have an antidepressant-like effect in mice by affecting the dopaminergic system. Dietary carvacrol supplementation prevents high fat diet-induced obesity by modulating gene expressions that lead to adipogenesis and inflammation. This chemical crosses the blood-brain barrier easily and rapidly.
References	[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886536/ [2] https://pubmed.ncbi.nlm.nih.gov/22438954/

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