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Palmatine chloride Chemical Structure
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Biological Activity
Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) is a hydrochloride salt of palmatine which is a protoberberine alkaloid. Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. [1] Palmatine inhibited carbachol-induced Ca2+-activated Cl− secretion and the carbachol-induced increase of intracellular Ca2+ concentration. Palmatine also inhibited cAMP-activated Cl− secretion induced by prostaglandin E2 (PGE2) or forskolin. Palmatine prevented the elevation of intracellular cAMP by forskolin. Determination of apical Cl− currents showed that palmatine suppressed the forskolin-stimulated, apical cAMP-activated Cl− current but not the carbachol-stimulated apical Ca2+-activated Cl− current. [2]
Chemical Information
| Molecular Weight (WM): | 387.86 |
|---|---|
| Formula: | C21H22NO4.Cl |
| CAS No.: | 10605-02-4 |
| Synonyms: |
Palmatine hydrochloride
|
| Dissolve in (25°C): | DMSO ≥78mg/mL |
| Water ≥20mg/mL | |
| Ethanol ≥17mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
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