Name: Astilbin
Brand: Selleck Chemicals
SKU: S3932
Rating: 5 (1 reviews)

Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.

Astilbin Chemical Structure

CAS: 29838-67-3

Purity & Quality Control

Batch: S393201 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.30%

99.30

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Biological Activity

Description	Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.

In vitro
In vitro	In vitro, astilbin inhibits Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibits Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions. Astilbin has been reported to possess multiple clinically relevant bioactivities, including antioxidant, anti-inflammatory, anti-arthritic, and anti-diabetic nephropathy properties. Nevertheless, the molecular mechanisms by which astilbin interacts with inflammatory processes are poorly understood. Astilbin not only inhibits T lymphocyte function in acute heart allograft rejection, but also inhibits migration and antigen presenting of dendritic cells (DCs)^[1].
Cell Research	Cell lines	CD4+ T cells
	Concentrations	0-100 μg/ml
	Incubation Time	3 days
	Method	Cell viability is assessed using the Cell Counting Kit-8 (CCK8) assay at 3 days after induction of Th17 differentiation. The mean optical density (OD) of the three wells in each group is used to calculate the percentage of cell proliferation.

In Vivo
In vivo	Astilbin is reported to reduce activation of both T and B cells in lupus-prone mice. It significantly inhibits inflammatory responses and keratinocyte over-proliferation in a mouse model of imiquimod (IMQ)-induced psoriasis^[1]. Astilbin undergoes extensive biotransformation specifically due to enzyme catechol-O-methyl transferase. It gives rise to 3′-O-methylastilbin, a major metabolite of astilbin, which plays important role against the inhibition activated T lymphocytes. The pharmacokinetic parameters of astilbin followed by intragastric administration astilbin (40 mg/kg): C_max=37.7±14.7 ng/mL, T_max=25.8±34.3 min, t_1/2=161.6±44.1 min^[2].
Animal Research	Animal Models	BALB/c mice (male, 18 to 20 g, 8 week-old)
	Dosages	25 to 50 mg/kg
	Administration	orally administered

References

Chemical Information & Solubility

Molecular Weight	450.39	Formula	C₂₁H₂₂O₁₁
CAS No.	29838-67-3	SDF	Download Astilbin SDF
Smiles	CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
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In vivo
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