Evodiamine

Catalog No.S2382

Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells.

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Evodiamine Chemical Structure

Evodiamine Chemical Structure
Molecular Weight: 303.36

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Product Description

Biological Activity

Description Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells.
LD50
In vitro Evodiamine (Isoevodiamine), an alkaloid extract from Evodiae Fructus exhibits antitumor activities against the human tumor cells. Evodiamine induces the substantial amount of apoptosis both in Bcl-2- and Akt-overexpressing U937 cells but not in human peripheral blood mononuclear cells via caspase-independent apoptotic pathways. [1] Evodiamine Evodiamine also inhibits tumor necrosis factor (TNF)-induced NF-kappaB and Akt activation but it has no effect on JNK or p38 MAPK activation. [2] In addition, Evodiamine is an human topoisomerase I inhibitor. [3]
In vivo LD50: Mice 77mg/kg (i.v.) [4]
Features

Protocol(Only for Reference)

1

References

[1] Lee TJ, et al. Mol Cancer Ther, 2006, 5(9), 2398-407.

[2] Takada Y, et al. J Biol Chem, 2005, 280(17), 17203-17212.

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Chemical Information

Download Evodiamine SDF
Molecular Weight (MW) 303.36
Formula

C19H17N3O

CAS No. 518-17-2
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Isoevodiamine
Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

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