Catalog No.S2382

Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells.

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Evodiamine Chemical Structure

Evodiamine Chemical Structure
Molecular Weight: 303.36

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Related Compound Libraries

Evodiamine is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells.
In vitro Evodiamine (Isoevodiamine), an alkaloid extract from Evodiae Fructus exhibits antitumor activities against the human tumor cells. Evodiamine induces the substantial amount of apoptosis both in Bcl-2- and Akt-overexpressing U937 cells but not in human peripheral blood mononuclear cells via caspase-independent apoptotic pathways. [1] Evodiamine Evodiamine also inhibits tumor necrosis factor (TNF)-induced NF-kappaB and Akt activation but it has no effect on JNK or p38 MAPK activation. [2] In addition, Evodiamine is an human topoisomerase I inhibitor. [3]
In vivo LD50: Mice 77mg/kg (i.v.) [4]

Protocol(Only for Reference)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.
Body Surface Area (m2)
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Lee TJ, et al. Mol Cancer Ther, 2006, 5(9), 2398-407.

[2] Takada Y, et al. J Biol Chem, 2005, 280(17), 17203-17212.

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Chemical Information

Download Evodiamine SDF
Molecular Weight (MW) 303.36


CAS No. 518-17-2
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Isoevodiamine
Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (13bS)-

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