Evodiamine

Catalog No.S2382

Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells.

Price Stock Quantity  
USD 50 In stock
USD 120 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Evodiamine Chemical Structure

Evodiamine Chemical Structure
Molecular Weight: 303.36

Validation & Quality Control

MSDS

Related Compound Libraries

Evodiamine is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells.
LD50
In vitro Evodiamine (Isoevodiamine), an alkaloid extract from Evodiae Fructus exhibits antitumor activities against the human tumor cells. Evodiamine induces the substantial amount of apoptosis both in Bcl-2- and Akt-overexpressing U937 cells but not in human peripheral blood mononuclear cells via caspase-independent apoptotic pathways. [1] Evodiamine Evodiamine also inhibits tumor necrosis factor (TNF)-induced NF-kappaB and Akt activation but it has no effect on JNK or p38 MAPK activation. [2] In addition, Evodiamine is an human topoisomerase I inhibitor. [3]
In vivo LD50: Mice 77mg/kg (i.v.) [4]
Features

Protocol(Only for Reference)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Lee TJ, et al. Mol Cancer Ther, 2006, 5(9), 2398-407.

[2] Takada Y, et al. J Biol Chem, 2005, 280(17), 17203-17212.

view more

Chemical Information

Download Evodiamine SDF
Molecular Weight (MW) 303.36
Formula

C19H17N3O

CAS No. 518-17-2
Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms Isoevodiamine
Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (13bS)-

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:2

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others Products

  • (S)-crizotinib

    (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

  • PTC-209

    PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).

  • KN-93 Phosphate

    KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.

  • CX-4945 (Silmitasertib)

    CX-4945 (Silmitasertib) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2.

    Features:First clinical inhibitor of CK2.

  • Tacrolimus (FK506)

    FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.

  • Bendamustine HCl

    Bendamustine HCL is a DNA-damaging agent with IC50 of 50 μM.

  • Cyclophosphamide Monohydrate

    Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

  • Cabazitaxel

    Cabazitaxel (XRP6258) is a semi-synthetic derivative of a natural taxoid.

    Features:A semi-synthetic derivative of a natural taxoid.

  • Verteporfin

    Verteporfin is a potent second-generation photosensitizing agent derived from porphyrin.

  • Cyclosporin A

    Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.

Recently Viewed Items

Tags: buy Evodiamine | Evodiamine ic50 | Evodiamine price | Evodiamine cost | Evodiamine solubility dmso | Evodiamine purchase | Evodiamine manufacturer | Evodiamine research buy | Evodiamine order | Evodiamine mouse | Evodiamine chemical structure | Evodiamine mw | Evodiamine molecular weight | Evodiamine datasheet | Evodiamine supplier | Evodiamine in vitro | Evodiamine cell line | Evodiamine concentration | Evodiamine nmr
Contact Us