Urolithin A

Synonyms: 3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin

Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.

Urolithin A Chemical Structure

Urolithin A Chemical Structure

CAS: 1143-70-0

Selleck's Urolithin A has been cited by 9 publications

Purity & Quality Control

Batch: Purity: 99.70%
99.70

Urolithin A Related Products

Choose Selective Mitophagy Inhibitors

Biological Activity

Description Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.
In vitro
In vitro

Urolithin A inhibits cell proliferation and reduces oxidative stress status in liver cancer.

Cell Research Cell lines HepG2 cells
Concentrations 137 µM
Incubation Time 24 h
Method

Cells were treated with various concentrations of drug for 24 h.

Experimental Result Images Methods Biomarkers Images PMID
Western blot p53 / p21 / TIGAR p-cdc2 / Cyclin B1 / Cyclin D1 30418550
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04783207 Completed
Healthy
Amazentis SA|Australian Catholic University
April 21 2021 Not Applicable

Chemical Information & Solubility

Molecular Weight 228.20 Formula

C13H8O4

CAS No. 1143-70-0 SDF --
Smiles C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 46 mg/mL ( (201.57 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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