(+)-Catechin

Catalog No.S4722 Synonyms: Cianidanol, Catechinic acid, Catechuic acid

(+)-Catechin Chemical Structure

Molecular Weight(MW): 290.27

Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

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Biological Activity

Description Cianidanol is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
Targets
COX-1 [3]
(Cell-based assay)
COX-2 [3]
(Cell-based assay)
80 μM 130 μM
In vitro

The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins[1]. Treatment of human prostate cancer cells with catechin induces apoptosis and results in effects on a variety of survival signals suggesting the potential of these compounds as chemopreventive agents for prostate cancer[2]. Catechin is well known to inhibit cyclooxygenase activity with reported IC50 values ranging from 4O μM to 943 μM. It has also been reported to act as an inhibitor of COX-1 and COX-2 with IC50 of about 80 µM and 130 μM[3].

In vivo Dietary catechin significantly delayed tumor onset[5]. Continued intake of catechin, a potential antioxidant, prevents memory regression and DNA oxidative damage in senescence-accelerated (SAMP10) mice. It does not prolong the lifetime of SAMP10 mice, but it does delay brain senescence[6]. (+)-Catechin inhibits intestinal tumor formation and suppresses Focal adhesion kinase activation in the Min/+ Mouse[7].

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: LB02 tumor cell line
  • Concentrations: 10, 50, 100 or 200 μg/mL
  • Incubation Time: 48 h
  • Method:

    LB02 cells were resuspended in RPMI 10% FBS in a concentration of 5x105 cells/mL. The cultures were performed in 96-well round-bottomed microtitre plates in presence of different concentrations of catechin or rutin (10, 50, 100 or 200 μg/mL). After 48 h at 37 ºC in a humidified atmosphere with 5% CO2 in the air, cultures were pulsed with 1 μCi of 3H-thymidine/well and maintained for an additional 18 h period prior to a semiautomatic method harvest.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: Kunming mice
  • Formulation: EDTA solution
  • Dosages: 1, 2, 3 mg/kg
  • Administration: stomach perfusion
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 58 mg/mL (199.81 mM)
Water 58 mg/mL (199.81 mM)
Ethanol 58 mg/mL (199.81 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 290.27
Formula

C15H14O6

CAS No. 154-23-4
Storage powder
Synonyms Cianidanol, Catechinic acid, Catechuic acid

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID