Catalog No.S2391 Synonyms: Sophoretin
Molecular Weight(MW): 302.24
Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
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|Description||Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.|
Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2.  Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. 
|In vivo||Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth. LD50: >3000mg/kg (i.g.) |
|In vitro||DMSO||61 mg/mL (201.82 mM)|
|Ethanol||10 mg/mL (33.08 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02989129||Not yet recruiting||Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain||M.D. Anderson Cancer Center||March 2017||Early Phase 1|
|NCT02446795||Recruiting||Renal Cell Carcinoma|Kidney Cancer||Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals||November 2016||Phase 1|Phase 2|
|NCT02874989||Recruiting||Idiopathic Pulmonary Fibrosis (IPF)||Wake Forest University Health Sciences|Mayo Clinic||August 2016||Phase 1|
|NCT02866448||Withdrawn||Cardiovascular Disease||University of Reading|Biotechnology and Biological Sciences Research Council|Quercegen Pharmaceuticals||August 2016||--|
|NCT02848131||Recruiting||Chronic Kidney Disease||Mayo Clinic||July 2016||Phase 2|
|NCT02652052||Recruiting||Stem Cell Transplant||Mayo Clinic||March 2016||--|
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