Quercetin

Catalog No.S2391 Synonyms: Sophoretin

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells M1;T[mZ2dmO2aX;uJIF{e2G7 NWjOfZN7UW6qaXLpeIlwdiCxZjDyZZQh\WO2bz21K{1vfWOuZX;0bYRie2ViZYjwdoV{e2WmIHnuJHNnQSClZXzsd{BjgSClYYDpcIxienliZXzlZ5Rzd3Cqb4Lld4l{KG2ndHjv[EwhU2l;NEWuN{BvVQ>? NWDWfFY4OjBzNE[0PFM>
RBL-1 cells MV3GeY5kfGmxbjDhd5NigQ>? NIizfWtKdiC4aYTyc{BqdmirYnn0bY9vKGGpYXnud5QhPS2uaYDvfJlo\W6jc3WgbY4hWkKOLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQtKEmFNUC9NE4zKM7:TR?= NVXvVplSQDJ3NE[yNC=>
HEK293 FS cells NEX3W5NHfW6ldHnvckBie3OjeR?= MXXJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTBwNkig{txO M1LS[lIxPzNzM{W3
RAW264.7 cells MXPGeY5kfGmxbjDhd5NigQ>? M2fOU|I1KGh? M{joU2lvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bi\nSncjCyOEBpenNuIFnDOVA:OS5|IN88US=> NVXFNWI2OjN3NEC5PFE>
human HeLa cells M2S0PGZ2dmO2aX;uJIF{e2G7 M3y4bGlvcGmkaYTpc44hd2ZiTWLQNUB1emGwc3\lZ5Rm\CCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiW{PIYWxVSzRidILhcpNxd3K2IHL5JJJieGmmIH\pcJRz[XSrb36gZZN{[XluIFvpQVIvPCEQvF2= MUixPVczPTV5OB?=
HT22 cells MUnGeY5kfGmxbjDhd5NigQ>? MkfUTY5pcWKrdHnvckBw\iCpbIX0ZY1ifGVvaX7keYNm\CCxeIn0c5NqeyCxZjDtc5V{\SCqaYDwc4NidXCjbDDIWFIzKGOnbHzzMEBGSzVyPUKuPVgh|ryP NVfETYVPOTZ|OUK4NVQ>
HT22 cells M1Hy[2Z2dmO2aX;uJIF{e2G7 MnvhUoV2em:ycn;0[YN1cX[nIHHjeIl3cXS7IHnuJI1wfXOnIFjUNlIh[2WubIOgZZN{\XO|ZXSgZZMheHKxdHXjeIlwdiCjZ3HpcpN1KGeudYThcYF1\S2rbnT1Z4VlKG:6aXTheIl3\SCmYX3h[4Uh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhTUN3ME2zMlE{KM7:TR?= MlK2NlQ3ODJ7MES=
NCI-H1792 cells MWXGeY5kfGmxbjDhd5NigQ>? NUXieXRMSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMUe5NkBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9N{45PSEQvF2= NFPCb3QzPTF|OUW2PS=>
human BV2 cells NH3xcXZHfW6ldHnvckBie3OjeR?= NEe4R28zPCCq M3vnRWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjDpckBpfW2jbjDCWlIh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCjc4PhfUwhUUN3ME20MlMh|ryP NI\rRlczPTF{N{G2OC=>
human HTLA cells NYLVcJBCTnWwY4Tpc44h[XO|YYm= MWOyNEBucW6| MkLJTY5pcWKrdHnvckBw\iCFWEPDUFEue3SrbYXsZZRm\CCFWEPDVlEhcW5iaIXtZY4hUFSOQTDj[YxteyCycnWtbY5kfWKjdHXkJIZweiB{MDDtbY5{KG2nYYP1doVlKG:wIHThfUA1KGK7IHLleIEh[XK{ZYP0bY4uemWlcoXpeI1mdnRibXXkbYF1\WRibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUSuOUDPxE1? MUiyN|Q{Pzd5Mh?=
human LOXIMVI cells M1rsPGZ2dmO2aX;uJIF{e2G7 NHGxcIRCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUG9ZUU2YSTDj[YxteyCkeTDIWHMh[XO|YYmsJGlEPTB;ND62OUDPxE1? NHX2ZpUzPTF|OUW2PS=>
Jurkat T cells NIDocINHfW6ldHnvckBie3OjeR?= M1f2d2FkfGm4aYT5JIFo[Wmwc4SgbJllem:pZX6gdIVzd3irZHWgbY5lfWOnZDDEUmEh\GGvYXflJIlvKEq3cnvheEBVKGOnbHzzMEBKSzVyPUWg{txO M4PxN|E3Ozl{OEG0
human HCT116 cells NGXvWY1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXW0PEBp NYPBZVlXT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKFCLM1vhcJBp[SCKMUC0O3IhdXW2YX70JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NT63JO69VQ>? NV;YPIZNOjJ{MUK3NlE>
human NCI-H522 cells MWLGeY5kfGmxbjDhd5NigQ>? NF3zcpNCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh3MkKgZ4VtdHNiYomgTHRUKGG|c3H5MEBKSzVyPUWuO|ch|ryP M{HpeVI2OTN7NU[5
human U2OS cells MXrGeY5kfGmxbjDhd5NigQ>? Mnz2RYdwdmm|dDDhZ5Rqfmm2eTDheEBIWFJ|NTDy[YNmeHSxcjDpckBpfW2jbjDVNm9UKGOnbHzzJINw\XiycnXzd4lv\yCJYXy0MXZROTZvVFXWJIF{e2W|c3XkJIF{KGKndHGgZZJz\XO2aX6geJJidnOub3PheIlwdiCjZoTldkA2KGi{czDifUBj\XSjIHzhZ5RidWG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUWuPVMh|ryP MmLUNlQ6ODB2NEe=
human NCI-H157 cells M1\Ud2Z2dmO2aX;uJIF{e2G7 NHHMXllCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzNUegZ4VtdHNiYomgTHRUKGG|c3H5MEBKSzVyPU[g{txO NG[5XoMzPTF|OUW2PS=>
human A549 cells MmLlSpVv[3Srb36gZZN{[Xl? MomwRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVYvOiEQvF2= MVyyOVE{QTV4OR?=
human HCT116 cells MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH\SVmo1QCCq Mn;zS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Ok44KM7:TR?= MojhNlIzOTJ5MkG=
MDCK cells MlTWSpVv[3Srb36gZZN{[Xl? NV3FU5ZyUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CCrbjDNSGNMKGOnbHzzJJV{cW6pIFjv[YNpe3RiM{OzOFIhe3SjaX7pcoctKEmFNUC9Ok46KM7:TR?= NXiwPI1oOjF|NUS4NFA>
human HOP62 cells M{O5[WZ2dmO2aX;uJIF{e2G7 M4DRUmFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIU3A3OiClZXzsd{BjgSCKVGOgZZN{[XluIFnDOVA:Py53MjFOwG0> NVqx[ItwOjVzM{m1Olk>
human H460 cells NHnjS2pHfW6ldHnvckBie3OjeR?= MWLBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSES2NEBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9PU43OiEQvF2= NV7y[FdLOjVzM{m1Olk>
human BV2 cells M1flXmZ2dmO2aX;uJIF{e2G7 M2HtUGFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gRnYzKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36gZpkhT3KrZYPzJIF{e2G7LDDJR|UxRTFyIN88US=> M37PXVI1PzB5OUO4
human MCF7 cells NXjvWpNIS3m2b4TvfIlkcXS7IHHzd4F6 MmfyO|IhcA>? MmLpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkCuPUDPxE1? M3HyNVI2QTB4M{i1
human 2008 cells NF:zd|NEgXSxdH;4bYNqfHliYYPzZZk> MU[3NkBp NELUW|VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAzODB6IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yNU4yQCEQvF2= M3\hPVI2QTB4M{i1
human A431 cells M1TMR2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYq3NkBp NVzxSZBUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlMvODRizszN MnfhNlU6ODZ|OEW=
human BxPC3 cells NHLwSXNEgXSxdH;4bYNqfHliYYPzZZk> MVe3NkBp MkTqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRphRSzNiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUK0MlEzKM7:TR?= MlfFNlU6ODZ|OEW=
human HepG2 cells MUXDfZRwfG:6aXPpeJkh[XO|YYm= M3rENWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1|MD65JO69VQ>? NUewbYtJOjF5Mk[wO|c>
human MDA-MB-231 cells NIrKPIRHfW6ldHnvckBie3OjeR?= M2fnZVIxKM7:TR?= MWGxNkBp M2r0bGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDjcIVifmWmIHPhd5Bie2VvNzDhZ4N2dXWuYYTpc44h[XRiMkCgeW0h[W[2ZYKgNVIhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NFTxW5MzOTZ3MkKwPC=>

... Click to View More Cell Line Experimental Data

In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
Synonyms Sophoretin

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02989129 Not yet recruiting Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain M.D. Anderson Cancer Center March 2017 Early Phase 1
NCT02446795 Recruiting Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT02874989 Recruiting Idiopathic Pulmonary Fibrosis (IPF) Wake Forest University Health Sciences|Mayo Clinic August 2016 Phase 1
NCT02866448 Withdrawn Cardiovascular Disease University of Reading|Biotechnology and Biological Sciences Research Council|Quercegen Pharmaceuticals August 2016 --
NCT02848131 Recruiting Chronic Kidney Disease Mayo Clinic July 2016 Phase 2
NCT02652052 Recruiting Stem Cell Transplant Mayo Clinic March 2016 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID