Quercetin

Catalog No.S2391 Synonyms: Sophoretin

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells MkTlSpVv[3Srb36gZZN{[Xl? NHfBWZBKdmirYnn0bY9vKG:oIILheEBm[3SxLUWnMY52[2ynb4Tp[IF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIJ6KGOjcHnscIFzgSCnbHXjeJJweGixcnXzbZMhdWW2aH;kMEBMcT12NT6zJI5O MYKyNFE1PjR6Mx?=
RBL-1 cells NFTwZ21HfW6ldHnvckBie3OjeR?= MVrJckB3cXS{bzDpcohq[mm2aX;uJIFo[Wmwc4SgOU1tcXCxeInn[Y5ie2ViaX6gVmJNNTFiY3XscJMhf2G|IHTleIVzdWmwZXSsJGlEPTB;MD6yJO69VQ>? MmToPFI2PDZ{MB?=
HEK293 FS cells MVPGeY5kfGmxbjDhd5NigQ>? NX;6[|RGUW6qaXLpeIlwdiCxZjDOU3g1KGW6cILld5Nm\CCrbjDISWszQTNiRmOgZ4VtdHNiYYPz[ZN{\WRiYYOgTFJQOiCycn;keYN1cW:wIHL5JGgzVzJxVInyM2xRVyCjc4PhfUwhUUN3ME2wMlY5KM7:TR?= NVvycph1OjB5M{GzOVc>
RAW264.7 cells NUTBblVxTnWwY4Tpc44h[XO|YYm= NVjHXmJ4OjRiaB?= NX7DXIZGUW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBPVyCycn;keYN1cW:wIHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGGodHXyJFI1KGi{czygTWM2OD1zLkOg{txO M{fTTFI{PTRyOUix
human HeLa cells MnTMSpVv[3Srb36gZZN{[Xl? MVnJcohq[mm2aX;uJI9nKE2UUEGgeJJidnOoZXP0[YQhcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFt|SG3MWGM1KHS{YX7zdI9zfCCkeTDyZZBq\CCoaXz0doF1cW:wIHHzd4F6NCCNaU2yMlQh|ryP MnPUNVk4OjV3N{i=
HT22 cells MmrBSpVv[3Srb36gZZN{[Xl? NEH2U|NKdmirYnn0bY9vKG:oIHfseZRidWG2ZT3pcoR2[2WmIH;4fZRwe2m|IH;mJI1wfXOnIHjpdJBw[2GvcHHsJGhVOjJiY3XscJMtKEWFNUC9Nk46QCEQvF2= NXzHVHdTOTZ|OUK4NVQ>
HT22 cells MlraSpVv[3Srb36gZZN{[Xl? MV\O[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{Bxem:2ZXP0bY9vKGGpYXnud5Qh\2y3dHHtZZRmNWmwZIXj[YQhd3irZHH0bZZmKGSjbXHn[UBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUOuNVMh|ryP MoW0NlQ3ODJ7MES=
NCI-H1792 cells NUfuXZZwTnWwY4Tpc44h[XO|YYm= NGrudplCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzN{myJINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME2zMlg2KM7:TR?= NYfpUFc1OjVzM{m1Olk>
human BV2 cells NWSwU4piTnWwY4Tpc44h[XO|YYm= MWmyOEBp MULJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25iaX6gbJVu[W5iQm[yJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCJcnnld5Mh[XO|YYmsJGlEPTB;ND6zJO69VQ>? MYeyOVEzPzF4NB?=
human HTLA cells Ml3hSpVv[3Srb36gZZN{[Xl? Mny2NlAhdWmwcx?= M1H6SGlvcGmkaYTpc44hd2ZiQ2izR2wyNXO2aX31cIF1\WRiQ2izR3IyKGmwIHj1cYFvKEiWTFGgZ4VtdHNicILlMYlv[3WkYYTl[EBnd3JiMkCgcYlveyCvZXHzeZJm\CCxbjDkZZkhPCCkeTDi[ZRiKGG{cnXzeIlvNXKnY4L1bZRu\W62IH3l[IlifGWmIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME20MlUh|ryP NYrNbHlHOjN2M{e3O|I>
human LOXIMVI cells M{n5TmZ2dmO2aX;uJIF{e2G7 M3LyWWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMU3hKVV[LIHPlcIx{KGK7IFjUV{Bie3OjeTygTWM2OD12Lk[1JO69VQ>? M4jOZVI2OTN7NU[5
Jurkat T cells M4j2XGZ2dmO2aX;uJIF{e2G7 M{DDOWFkfGm4aYT5JIFo[Wmwc4SgbJllem:pZX6gdIVzd3irZHWgbY5lfWOnZDDEUmEh\GGvYXflJIlvKEq3cnvheEBVKGOnbHzzMEBKSzVyPUWg{txO M4H6ZVE3Ozl{OEG0
human HCT116 cells NUS3ZlRuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{XuXFQ5KGh? NV3OWo96T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKFCLM1vhcJBp[SCKMUC0O3IhdXW2YX70JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NT63JO69VQ>? NXLVRWpPOjJ{MUK3NlE>
human NCI-H522 cells NWjoclR[TnWwY4Tpc44h[XO|YYm= NITFbI1CdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh3MkKgZ4VtdHNiYomgTHRUKGG|c3H5MEBKSzVyPUWuO|ch|ryP MYiyOVE{QTV4OR?=
human U2OS cells MXzGeY5kfGmxbjDhd5NigQ>? MWrB[49vcXO2IHHjeIl3cXS7IHH0JGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIGWyU3Mh[2WubIOgZ49mgHC{ZYPzbY5oKEejbEStWnAyPi2WRW[gZZN{\XO|ZXSgZZMh[mW2YTDhdpJme3SrbjD0doFve2yxY3H0bY9vKGGodHXyJFUhcHK|IHL5JIJmfGFibHHjeIFu[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;NT65N{DPxE1? NH;NPHMzPDlyMES0Oy=>
human NCI-H157 cells NWW4XmhLTnWwY4Tpc44h[XO|YYm= NX;YRZBKSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMUW3JINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME22JO69VQ>? MWiyOVE{QTV4OR?=
human A549 cells NXK3eZFyTnWwY4Tpc44h[XO|YYm= M4TjOGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIJ6KEiWUzDhd5NigSxiSVO1NF03NjJizszN NIHodFgzPTF|OUW2PS=>
human HCT116 cells NHuwfYlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3zO[VQ5KGh? NFfBVoRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF03NjdizszN NWXGeJhuOjJ{MUK3NlE>
MDCK cells MXjGeY5kfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNidYPpcochUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzygTWM2OD14Lkmg{txO M33UXFIyOzV2OECw
human HOP62 cells MV;GeY5kfGmxbjDhd5NigQ>? M1;QZ2FvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIU3A3OiClZXzsd{BjgSCKVGOgZZN{[XluIFnDOVA:Py53MjFOwG0> NXj0WlNpOjVzM{m1Olk>
human H460 cells MoLuSpVv[3Srb36gZZN{[Xl? MlTXRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFi0OlAh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVkvPjJizszN M1Owc|I2OTN7NU[5
human BV2 cells NEDLO4JHfW6ldHnvckBie3OjeR?= MX3BcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFLWNkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIHL5JGdzcWW|czDhd5NigSxiSVO1NF0yOCEQvF2= NXX4SWZiOjR5MEe5N|g>
human MCF7 cells MUXDfZRwfG:6aXPpeJkh[XO|YYm= M4nEbFczKGh? NUHt[pFbS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlAvQSEQvF2= NHf4e44zPTlyNkO4OS=>
human 2008 cells NWjPXIJxS3m2b4TvfIlkcXS7IHHzd4F6 NUHDfIdGPzJiaB?= NISy[G5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAzODB6IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yNU4yQCEQvF2= NU\xbmw3OjV7ME[zPFU>
human A431 cells NEHoZlREgXSxdH;4bYNqfHliYYPzZZk> M2qycFczKGh? NWHQUFI5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlMvODRizszN MVWyOVkxPjN6NR?=
human BxPC3 cells NFrhNWVEgXSxdH;4bYNqfHliYYPzZZk> NGLHU4I4OiCq MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCfHBEOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkSuNVIh|ryP NITUdnUzPTlyNkO4OS=>
human HepG2 cells MWjDfZRwfG:6aXPpeJkh[XO|YYm= M2j4d2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1|MD65JO69VQ>? Mm[xNlE4OjZyN{e=
human MDA-MB-231 cells NULPeWxWTnWwY4Tpc44h[XO|YYm= M4OyXlIxKM7:TR?= MUWxNkBp MXjJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2GQT3NRk0zOzFiY3XscJMh[XO|ZYPz[YQh[XNiY3zlZZZm\CClYYPwZZNmNTdiYXPjeY12dGG2aX;uJIF1KDJyIIXNJIFnfGW{IEGyJIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> MknWNlE3PTJ{MEi=

... Click to View More Cell Line Experimental Data

In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
Synonyms Sophoretin

Bio Calculators

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02989129 Not yet recruiting Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain M.D. Anderson Cancer Center March 2017 Early Phase 1
NCT02446795 Recruiting Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT02874989 Recruiting Idiopathic Pulmonary Fibrosis (IPF) Wake Forest University Health Sciences|Mayo Clinic August 2016 Phase 1
NCT02866448 Withdrawn Cardiovascular Disease University of Reading|Biotechnology and Biological Sciences Research Council|Quercegen Pharmaceuticals August 2016 --
NCT02848131 Recruiting Chronic Kidney Disease Mayo Clinic July 2016 Phase 2
NCT02652052 Recruiting Stem Cell Transplant Mayo Clinic March 2016 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID