Quercetin

Catalog No.S2391 Synonyms: Sophoretin

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells M1\DdWZ2dmO2aX;uJIF{e2G7 MWTJcohq[mm2aX;uJI9nKHKjdDDlZ5RwNTVpLX71Z4xmd3SrZHHz[UBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHL5JINieGmubHHyfUBmdGWldILvdIhwemW|aYOgcYV1cG:mLDDLbV01PS5|IH7N NUHuR|g2OjBzNE[0PFM>
RBL-1 cells NVz6VWNWTnWwY4Tpc44h[XO|YYm= MmjuTY4hfmm2cn:gbY5pcWKrdHnvckBi\2GrboP0JFUudGmyb4j5[4Vv[XOnIHnuJHJDVC1zIHPlcIx{KHejczDk[ZRmem2rbnXkMEBKSzVyPUCuNkDPxE1? Mn3IPFI2PDZ{MB?=
HEK293 FS cells MkH1SpVv[3Srb36gZZN{[Xl? MUHJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTBwNkig{txO NYjFeXV6OjB5M{GzOVc>
RAW264.7 cells MkO3SpVv[3Srb36gZZN{[Xl? M1z2WlI1KGh? M4jwU2lvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bi\nSncjCyOEBpenNuIFnDOVA:OS5|IN88US=> NWHpOW13OjN3NEC5PFE>
human HeLa cells MULGeY5kfGmxbjDhd5NigQ>? MYDJcohq[mm2aX;uJI9nKE2UUEGgeJJidnOoZXP0[YQhcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFt|SG3MWGM1KHS{YX7zdI9zfCCkeTDyZZBq\CCoaXz0doF1cW:wIHHzd4F6NCCNaU2yMlQh|ryP NVvHWlNoOTl5MkW1O|g>
HT22 cells MV3GeY5kfGmxbjDhd5NigQ>? MkDzTY5pcWKrdHnvckBw\iCpbIX0ZY1ifGVvaX7keYNm\CCxeIn0c5NqeyCxZjDtc5V{\SCqaYDwc4NidXCjbDDIWFIzKGOnbHzzMEBGSzVyPUKuPVgh|ryP M4[1XFE3Ozl{OEG0
HT22 cells NV3wbnRFTnWwY4Tpc44h[XO|YYm= NWLH[oM6VmW3cn;wdo91\WO2aY\lJIFkfGm4aYT5JIlvKG2xdYPlJGhVOjJiY3XscJMh[XO|ZYPz[YQh[XNicILveIVkfGmxbjDh[4FqdnO2IHfseZRidWG2ZT3pcoR2[2WmIH;4bYRifGm4ZTDkZY1i\2ViYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiRVO1NF0{NjF|IN88US=> NH7Y[HQzPDZyMkmwOC=>
NCI-H1792 cells Moq3SpVv[3Srb36gZZN{[Xl? MkTMRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTd7MjDj[YxteyCkeTDIWHMh[XO|YYmsJGlEPTB;Mz64OUDPxE1? M4\Jc|I2OTN7NU[5
human BV2 cells MUDGeY5kfGmxbjDhd5NigQ>? MVuyOEBp MYXJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25iaX6gbJVu[W5iQm[yJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCJcnnld5Mh[XO|YYmsJGlEPTB;ND6zJO69VQ>? NWDaXmJ2OjVzMkexOlQ>
human HTLA cells MkPJSpVv[3Srb36gZZN{[Xl? M4fLfFIxKG2rboO= MnjBTY5pcWKrdHnvckBw\iCFWEPDUFEue3SrbYXsZZRm\CCFWEPDVlEhcW5iaIXtZY4hUFSOQTDj[YxteyCycnWtbY5kfWKjdHXkJIZweiB{MDDtbY5{KG2nYYP1doVlKG:wIHThfUA1KGK7IHLleIEh[XK{ZYP0bY4uemWlcoXpeI1mdnRibXXkbYF1\WRibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUSuOUDPxE1? MUCyN|Q{Pzd5Mh?=
human LOXIMVI cells NGXQVZJHfW6ldHnvckBie3OjeR?= MnfGRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzPXGlOXkliY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTRwNkWg{txO Mm\YNlUyOzl3Nkm=
Jurkat T cells MYrGeY5kfGmxbjDhd5NigQ>? MkHiRYN1cX[rdImgZYdicW6|dDDofYRzd2enbjDw[ZJwgGmmZTDpcoR2[2WmIFTORUBl[W2jZ3WgbY4hUnW{a3H0JHQh[2WubIOsJGlEPTB;NTFOwG0> NGjH[28yPjN7MkixOC=>
human HCT116 cells MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{LUfFQ5KGh? NUPlR|JiT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IH;2[ZJmgHC{ZYPzbY5oKFCLM1vhcJBp[SCKMUC0O3IhdXW2YX70JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NT63JO69VQ>? NVH0Z4R3OjJ{MUK3NlE>
human NCI-H522 cells MYPGeY5kfGmxbjDhd5NigQ>? NFLofVRCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh3MkKgZ4VtdHNiYomgTHRUKGG|c3H5MEBKSzVyPUWuO|ch|ryP NXrWUod6OjVzM{m1Olk>
human U2OS cells M4jXeWZ2dmO2aX;uJIF{e2G7 NIfBWJFC\2:waYP0JIFkfGm4aYT5JIF1KEeSUkO1JJJm[2WydH;yJIlvKGi3bXHuJHUzV1NiY3XscJMh[2:neIDy[ZN{cW6pIFfhcFQuXlBzNj3USXYh[XO|ZYPz[YQh[XNiYnX0ZUBienKnc4TpckB1emGwc3zvZ4F1cW:wIHHmeIVzKDViaILzJIJ6KGKndHGgcIFkfGGvYYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9OU46OyEQvF2= M13LNFI1QTByNES3
human NCI-H157 cells MV7GeY5kfGmxbjDhd5NigQ>? MmjWRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTV5IHPlcIx{KGK7IFjUV{Bie3OjeTygTWM2OD14IN88US=> NGW4R5ozPTF|OUW2PS=>
human A549 cells Ml7USpVv[3Srb36gZZN{[Xl? MlrURY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVYvOiEQvF2= MX[yOVE{QTV4OR?=
human HCT116 cells M2O2emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\De4Q1QCCq NX\UNIpoT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi55IN88US=> M2HrUVIzOjF{N{Kx
MDCK cells NUnNSJVzTnWwY4Tpc44h[XO|YYm= NV;sc3p7UW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CCrbjDNSGNMKGOnbHzzJJV{cW6pIFjv[YNpe3RiM{OzOFIhe3SjaX7pcoctKEmFNUC9Ok46KM7:TR?= MUKyNVM2PDhyMB?=
human HOP62 cells NETpOJRHfW6ldHnvckBie3OjeR?= MYXBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSF;QOlIh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVcvPTJizszN MlPzNlUyOzl3Nkm=
human H460 cells M{eyWGZ2dmO2aX;uJIF{e2G7 Mkm5RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFi0OlAh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVkvPjJizszN NGjvOlQzPTF|OUW2PS=>
human BV2 cells Mnv5SpVv[3Srb36gZZN{[Xl? NYLvZZE4SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBDXjJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNvaX7keYNm\CCwaYTybYMhd3irZHWgdJJw\HWldHnvckBjgSCJcnnld5Mh[XO|YYmsJGlEPTB;MUCg{txO MYmyOFcxPzl|OB?=
human MCF7 cells MW\DfZRwfG:6aXPpeJkh[XO|YYm= NImyPWQ4OiCq MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{MD65JO69VQ>? MYmyOVkxPjN6NR?=
human 2008 cells Mn3wR5l1d3SxeHnjbZR6KGG|c3H5 NYqyenFzPzJiaB?= M4r0bmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFIxODhiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKxMlE5KM7:TR?= NGizb|AzPTlyNkO4OS=>
human A431 cells MVHDfZRwfG:6aXPpeJkh[XO|YYm= NF[wN4Y4OiCq MnLvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkOuNFQh|ryP MmPRNlU6ODZ|OEW=
human BxPC3 cells MofkR5l1d3SxeHnjbZR6KGG|c3H5 MYq3NkBp NIWzOWFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDgFCFMzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlQvOTJizszN M1LwOlI2QTB4M{i1
human HepG2 cells M4TyOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OzBwOTFOwG0> M1j2S|IyPzJ4MEe3
human MDA-MB-231 cells MneySpVv[3Srb36gZZN{[Xl? MmXKNlAh|ryP M1PBV|EzKGh? M2rrS2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDjcIVifmWmIHPhd5Bie2VvNzDhZ4N2dXWuYYTpc44h[XRiMkCgeW0h[W[2ZYKgNVIhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NY\ES|NLOjF4NUKyNFg>

... Click to View More Cell Line Experimental Data

In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
Synonyms Sophoretin

Bio Calculators

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02989129 Not yet recruiting Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain M.D. Anderson Cancer Center March 2017 Early Phase 1
NCT02446795 Recruiting Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT02874989 Recruiting Idiopathic Pulmonary Fibrosis (IPF) Wake Forest University Health Sciences|Mayo Clinic August 2016 Phase 1
NCT02866448 Withdrawn Cardiovascular Disease University of Reading|Biotechnology and Biological Sciences Research Council|Quercegen Pharmaceuticals August 2016 --
NCT02848131 Recruiting Chronic Kidney Disease Mayo Clinic July 2016 Phase 2
NCT02652052 Recruiting Stem Cell Transplant Mayo Clinic March 2016 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID