Quercetin

Catalog No.S2391 Synonyms: Sophoretin

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells MWDGeY5kfGmxbjDhd5NigQ>? MnjSTY5pcWKrdHnvckBw\iC{YYSg[YN1dy13Jz3ueYNt\W:2aXThd4Uh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDifUBk[XCrbHzhdpkh\WynY4Tyc5Bpd3Knc3nzJI1mfGixZDygT4k:PDVwMzDuUS=> M1uxRlIxOTR4NEiz
RBL-1 cells MlHVSpVv[3Srb36gZZN{[Xl? MonxTY4hfmm2cn:gbY5pcWKrdHnvckBi\2GrboP0JFUudGmyb4j5[4Vv[XOnIHnuJHJDVC1zIHPlcIx{KHejczDk[ZRmem2rbnXkMEBKSzVyPUCuNkDPxE1? MoLUPFI2PDZ{MB?=
HEK293 FS cells NHjSPXdHfW6ldHnvckBie3OjeR?= MWXJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTBwNkig{txO NXjDOHZyOjB5M{GzOVc>
RAW264.7 cells NF3lTGJHfW6ldHnvckBie3OjeR?= MXKyOEBp NYm0NXdQUW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBPVyCycn;keYN1cW:wIHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGGodHXyJFI1KGi{czygTWM2OD1zLkOg{txO MVGyN|U1ODl6MR?=
human HeLa cells NWnpWFl4TnWwY4Tpc44h[XO|YYm= NYOzPGtrUW6qaXLpeIlwdiCxZjDNVnAyKHS{YX7z[oVkfGWmIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2heVFSFNDD0doFve3CxcoSgZpkhemGyaXSg[oltfHKjdHnvckBie3OjeTygT4k:Oi52IN88US=> NVS0UHpIOTl5MkW1O|g>
HT22 cells NV3aOoF6TnWwY4Tpc44h[XO|YYm= NXfjUpRTUW6qaXLpeIlwdiCxZjDncJV1[W2jdHWtbY5lfWOnZDDvfJl1d3OrczDv[kBud3W|ZTDobZBxd2OjbYDhcEBJXDJ{IHPlcIx{NCCHQ{WwQVIvQThizszN Ml\LNVY{QTJ6MUS=
HT22 cells NFH6U4dHfW6ldHnvckBie3OjeR?= NHrwSWFP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgbY4hdW:3c3WgTHQzOiClZXzsd{Bie3Onc4Pl[EBieyCycn;0[YN1cW:wIHHnZYlve3RiZ3z1eIFu[XSnLXnu[JVk\WRib4jp[IF1cX[nIHThcYFo\SCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCHQ{WwQVMvOTNizszN NWjlSWU3OjR4MEK5NFQ>
NCI-H1792 cells M3zKPGZ2dmO2aX;uJIF{e2G7 NEOxNFlCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUhzN{myJINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME2zMlg2KM7:TR?= M3fZXFI2OTN7NU[5
human BV2 cells M1v2UWZ2dmO2aX;uJIF{e2G7 NHjhN5czPCCq MkDrTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBPVyCycn;keYN1cW:wIHnuJIh2dWGwIFLWNkBk\WyuczDh[pRmeiB{NDDodpMh[nliR4Lp[ZN{KGG|c3H5MEBKSzVyPUSuN{DPxE1? MYWyOVEzPzF4NB?=
human HTLA cells MUnGeY5kfGmxbjDhd5NigQ>? MUeyNEBucW6| NEDwfXVKdmirYnn0bY9vKG:oIFPYN2NNOS2|dHnteYxifGWmIFPYN2NTOSCrbjDoeY1idiCKVFzBJINmdGy|IIDy[U1qdmO3YnH0[YQh\m:{IEKwJI1qdnNibXXhd5Vz\WRib36g[IF6KDRiYomgZoV1[SCjcoLld5Rqdi2{ZXPyeYl1dWWwdDDt[YRq[XSnZDDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9OE42KM7:TR?= NUDjZnluOjN2M{e3O|I>
human LOXIMVI cells MYHGeY5kfGmxbjDhd5NigQ>? MYjBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTF;YTW1XUSClZXzsd{BjgSCKVGOgZZN{[XluIFnDOVA:PC54NTFOwG0> MYWyOVE{QTV4OR?=
Jurkat T cells NX\lZ2ZNTnWwY4Tpc44h[XO|YYm= MUXBZ5Rqfmm2eTDh[4FqdnO2IHj5[JJw\2WwIIDldo95cWSnIHnu[JVk\WRiRF7BJIRidWGpZTDpckBLfXKtYYSgWEBk\WyuczygTWM2OD13IN88US=> NF3YNmIyPjN7MkixOC=>
human HCT116 cells M{HvR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmOzOFghcA>? MmPiS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJHBKO0ujbIDoZUBJOTB2N2KgcZV1[W62IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PS55IN88US=> NU\iT4p4OjJ{MUK3NlE>
human NCI-H522 cells MmnxSpVv[3Srb36gZZN{[Xl? NYX2[GV2SW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNUKyJINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME21Mlc4KM7:TR?= MlTYNlUyOzl3Nkm=
human U2OS cells MkXjSpVv[3Srb36gZZN{[Xl? NX\re21MSWexbnnzeEBi[3Srdnn0fUBifCCJUGKzOUBz\WOncITvdkBqdiCqdX3hckBWOk:VIHPlcIx{KGOxZYjwdoV{e2mwZzDHZYw1NV[SMU[tWGVXKGG|c3Xzd4VlKGG|IHLleIEh[XK{ZYP0bY4hfHKjboPsc4NifGmxbjDh[pRmeiB3IHjyd{BjgSCkZYThJIxi[3SjbXHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVUvQTNizszN MknjNlQ6ODB2NEe=
human NCI-H157 cells M330WWZ2dmO2aX;uJIF{e2G7 Mn\6RY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTV5IHPlcIx{KGK7IFjUV{Bie3OjeTygTWM2OD14IN88US=> M4LBWFI2OTN7NU[5
human A549 cells MVrGeY5kfGmxbjDhd5NigQ>? MYrBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9Ok4zKM7:TR?= NUG4WoNHOjVzM{m1Olk>
human HCT116 cells M{nHfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn7IOFghcA>? NUXYXll7T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi55IN88US=> NGrOV4YzOjJzMkeyNS=>
MDCK cells M4rlUmZ2dmO2aX;uJIF{e2G7 NGPoV4hKdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKGmwIF3ER2sh[2WubIOgeZNqdmdiSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{whUUN3ME22Mlkh|ryP NVfFbnZkOjF|NUS4NFA>
human HOP62 cells MYHGeY5kfGmxbjDhd5NigQ>? MWTBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSF;QOlIh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVcvPTJizszN M1z5dlI2OTN7NU[5
human H460 cells MYfGeY5kfGmxbjDhd5NigQ>? NF\aboZCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTFQ3OCClZXzsd{BjgSCKVGOgZZN{[XluIFnDOVA:QS54MjFOwG0> M2qyVlI2OTN7NU[5
human BV2 cells MljCSpVv[3Srb36gZZN{[Xl? NFjLTXpCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJGJXOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKG6rdILpZ{BwgGmmZTDwdo9lfWO2aX;uJIJ6KEe{aXXzd{Bie3OjeTygTWM2OD1zMDFOwG0> Ml;ONlQ4ODd7M{i=
human MCF7 cells NFvPdXhEgXSxdH;4bYNqfHliYYPzZZk> NHXifY84OiCq NH\x[4xEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yNE46KM7:TR?= NInEWYgzPTlyNkO4OS=>
human 2008 cells MXPDfZRwfG:6aXPpeJkh[XO|YYm= NIPzVVM4OiCq MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCyNFA5KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{MT6xPEDPxE1? NXvZeXlvOjV7ME[zPFU>
human A431 cells NV3zZY9wS3m2b4TvfIlkcXS7IHHzd4F6 M1vaXFczKGh? M1TjXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKzMlA1KM7:TR?= NXXhb|Z2OjV7ME[zPFU>
human BxPC3 cells MYHDfZRwfG:6aXPpeJkh[XO|YYm= M3TtPFczKGh? M4DneGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJ5WEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yOE4yOiEQvF2= NXXseJQ3OjV7ME[zPFU>
human HepG2 cells MYTDfZRwfG:6aXPpeJkh[XO|YYm= MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OzBwOTFOwG0> NXXzZ3E5OjF5Mk[wO|c>
human MDA-MB-231 cells M{DTW2Z2dmO2aX;uJIF{e2G7 NX[yeo9QOjBizszN NXPiVXlZOTJiaB?= MkXOTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGG|c3Xzd4VlKGG|IHPs[YF3\WRiY3HzdIF{\S15IHHjZ5VufWyjdHnvckBifCB{MDD1UUBi\nSncjCxNkBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ M3KwV|IyPjV{MkC4

... Click to View More Cell Line Experimental Data

In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
Synonyms Sophoretin

Bio Calculators

Molarity Calculator

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02989129 Not yet recruiting Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain M.D. Anderson Cancer Center March 2017 Early Phase 1
NCT02446795 Recruiting Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT02874989 Recruiting Idiopathic Pulmonary Fibrosis (IPF) Wake Forest University Health Sciences|Mayo Clinic August 2016 Phase 1
NCT02866448 Withdrawn Cardiovascular Disease University of Reading|Biotechnology and Biological Sciences Research Council|Quercegen Pharmaceuticals August 2016 --
NCT02848131 Recruiting Chronic Kidney Disease Mayo Clinic July 2016 Phase 2
NCT02652052 Recruiting Stem Cell Transplant Mayo Clinic March 2016 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID