Quercetin

Catalog No.S2391 Synonyms: Sophoretin

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

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  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

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Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells M1foS2Z2dmO2aX;uJIF{e2G7 NWK5UWozUW6qaXLpeIlwdiCxZjDyZZQh\WO2bz21K{1vfWOuZX;0bYRie2ViZYjwdoV{e2WmIHnuJHNnQSClZXzsd{BjgSClYYDpcIxienliZXzlZ5Rzd3Cqb4Lld4l{KG2ndHjv[EwhU2l;NEWuN{BvVQ>? MkPzNlAyPDZ2OEO=
RBL-1 cells NW\IT3hQTnWwY4Tpc44h[XO|YYm= NH74UodKdiC4aYTyc{BqdmirYnn0bY9vKGGpYXnud5QhPS2uaYDvfJlo\W6jc3WgbY4hWkKOLUGgZ4VtdHNid3HzJIRmfGW{bXnu[YQtKEmFNUC9NE4zKM7:TR?= NH7Gb|U5OjV2NkKw
HEK293 FS cells MWXGeY5kfGmxbjDhd5NigQ>? Mn7ETY5pcWKrdHnvckBw\iCQT2i0JIV5eHKnc4Pl[EBqdiCKRVuyPVMhTlNiY3XscJMh[XO|ZYPz[YQh[XNiSELPNkBxem:mdXP0bY9vKGK7IFiyU|IwXHm{L1zQU{Bie3OjeTygTWM2OD1yLk[4JO69VQ>? MmDaNlA4OzF|NUe=
RAW264.7 cells NW\IRW9xTnWwY4Tpc44h[XO|YYm= MnvvNlQhcA>? MUHJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIF7PJJBzd2S3Y4Tpc44hcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZYZ1\XJiMkSgbJJ{NCCLQ{WwQVEvOyEQvF2= MonzNlM2PDB7OEG=
human HeLa cells M2qzc2Z2dmO2aX;uJIF{e2G7 NFTod4ZKdmirYnn0bY9vKG:oIF3SVFEhfHKjboPm[YN1\WRiaX6gbJVu[W5iSHXMZUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGuzTH1NXEN2IITyZY5{eG:{dDDifUBz[XCrZDDmbYx1emG2aX;uJIF{e2G7LDDLbV0zNjRizszN MofwNVk4OjV3N{i=
HT22 cells NHnSZWdHfW6ldHnvckBie3OjeR?= MUfJcohq[mm2aX;uJI9nKGeudYThcYF1\S2rbnT1Z4VlKG:6eYTvd4l{KG:oIH3veZNmKGircIDvZ4FueGGuIFjUNlIh[2WubIOsJGVEPTB;Mj65PEDPxE1? M{T5blE3Ozl{OEG0
HT22 cells M1jaVmZ2dmO2aX;uJIF{e2G7 M{LMN25mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBud3W|ZTDIWFIzKGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlZ5Rqd25iYXfhbY5{fCCpbIX0ZY1ifGVvaX7keYNm\CCxeHnkZZRqfmViZHHtZYdmKGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEWFNUC9N{4yOyEQvF2= MWGyOFYxOjlyNB?=
NCI-H1792 cells M4LwNmZ2dmO2aX;uJIF{e2G7 MnnxRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTd7MjDj[YxteyCkeTDIWHMh[XO|YYmsJGlEPTB;Mz64OUDPxE1? MoDBNlUyOzl3Nkm=
human BV2 cells MWjGeY5kfGmxbjDhd5NigQ>? Mln1NlQhcA>? MUDJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25iaX6gbJVu[W5iQm[yJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCJcnnld5Mh[XO|YYmsJGlEPTB;ND6zJO69VQ>? M3y1cVI2OTJ5MU[0
human HTLA cells M{P5XWZ2dmO2aX;uJIF{e2G7 MWKyNEBucW6| NX\QOVRpUW6qaXLpeIlwdiCxZjDDXFNEVDFvc4TpcZVt[XSnZDDDXFNEWjFiaX6gbJVu[W5iSGTMRUBk\WyuczDwdoUucW6ldXLheIVlKG[xcjCyNEBucW6|IH3lZZN2emWmIH;uJIRigSB2IHL5JIJmfGFiYYLy[ZN1cW5vcnXjdpVqfG2nboSgcYVlcWG2ZXSgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVQvPSEQvF2= M1Xi[lI{PDN5N{ey
human LOXIMVI cells MoDBSpVv[3Srb36gZZN{[Xl? MnXLRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzPXGlOXkliY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTRwNkWg{txO MorGNlUyOzl3Nkm=
Jurkat T cells NGrrdJpHfW6ldHnvckBie3OjeR?= Mo[xRYN1cX[rdImgZYdicW6|dDDofYRzd2enbjDw[ZJwgGmmZTDpcoR2[2WmIFTORUBl[W2jZ3WgbY4hUnW{a3H0JHQh[2WubIOsJGlEPTB;NTFOwG0> NXX3NlZXOTZ|OUK4NVQ>
human HCT116 cells MlfiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHfEO5M1QCCq NI\6Z|hIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNib4\ldoV5eHKnc4PpcochWEl|S3HsdIhiKEhzMES3VkBufXSjboSgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13Lkeg{txO NFXMVnMzOjJzMkeyNS=>
human NCI-H522 cells M3nLO2Z2dmO2aX;uJIF{e2G7 NFW4UHdCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gUmNKNUh3MkKgZ4VtdHNiYomgTHRUKGG|c3H5MEBKSzVyPUWuO|ch|ryP NEjBcGQzPTF|OUW2PS=>
human U2OS cells MYrGeY5kfGmxbjDhd5NigQ>? NXLuZ3QxSWexbnnzeEBi[3Srdnn0fUBifCCJUGKzOUBz\WOncITvdkBqdiCqdX3hckBWOk:VIHPlcIx{KGOxZYjwdoV{e2mwZzDHZYw1NV[SMU[tWGVXKGG|c3Xzd4VlKGG|IHLleIEh[XK{ZYP0bY4hfHKjboPsc4NifGmxbjDh[pRmeiB3IHjyd{BjgSCkZYThJIxi[3SjbXHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVUvQTNizszN NInYXIszPDlyMES0Oy=>
human NCI-H157 cells M33DV2Z2dmO2aX;uJIF{e2G7 MlvWRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTV5IHPlcIx{KGK7IFjUV{Bie3OjeTygTWM2OD14IN88US=> NEDpPJAzPTF|OUW2PS=>
human A549 cells NV[xV|g4TnWwY4Tpc44h[XO|YYm= MYjBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9Ok4zKM7:TR?= NHfxc3gzPTF|OUW2PS=>
human HCT116 cells MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWq0PEBp MYLHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME22Mlch|ryP MmfUNlIzOTJ5MkG=
MDCK cells NVHEWXlXTnWwY4Tpc44h[XO|YYm= NGfZNmxKdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKGmwIF3ER2sh[2WubIOgeZNqdmdiSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{whUUN3ME22Mlkh|ryP NXHqO|NYOjF|NUS4NFA>
human HOP62 cells Ml;ISpVv[3Srb36gZZN{[Xl? Ml:zRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjPVFYzKGOnbHzzJIJ6KEiWUzDhd5NigSxiSVO1NF04NjV{IN88US=> MmfnNlUyOzl3Nkm=
human H460 cells MV3GeY5kfGmxbjDhd5NigQ>? MVHBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSES2NEBk\WyuczDifUBJXFNiYYPzZZktKEmFNUC9PU43OiEQvF2= NInVU|kzPTF|OUW2PS=>
human BV2 cells M{js[GZ2dmO2aX;uJIF{e2G7 NEHObFdCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJGJXOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKG6rdILpZ{BwgGmmZTDwdo9lfWO2aX;uJIJ6KEe{aXXzd{Bie3OjeTygTWM2OD1zMDFOwG0> Ml;ONlQ4ODd7M{i=
human MCF7 cells M2KxSmN6fG:2b4jpZ4l1gSCjc4PhfS=> NXvnc3dDPzJiaB?= NXjpSYUzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlAvQSEQvF2= NWrrfGRiOjV7ME[zPFU>
human 2008 cells NXPINVRnS3m2b4TvfIlkcXS7IHHzd4F6 NU\CV3dGPzJiaB?= Mn;CR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNlAxQCClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkGuNVgh|ryP MWWyOVkxPjN6NR?=
human A431 cells NXOwVmhHS3m2b4TvfIlkcXS7IHHzd4F6 MorLO|IhcA>? NEHVeGlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yN{4xPCEQvF2= NH3VTWkzPTlyNkO4OS=>
human BxPC3 cells MWjDfZRwfG:6aXPpeJkh[XO|YYm= NHm2dWo4OiCq M1zWTmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJ5WEN|IHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2yOE4yOiEQvF2= M17ZWVI2QTB4M{i1
human HepG2 cells NFzOZZNEgXSxdH;4bYNqfHliYYPzZZk> NF;IcFREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;M{CuPUDPxE1? NEHIepYzOTd{NkC3Oy=>
human MDA-MB-231 cells MX\GeY5kfGmxbjDhd5NigQ>? NYLHZllsOjBizszN Moe0NVIhcA>? NWPhZZV{UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJINt\WG4ZXSgZ4F{eGG|ZT23JIFk[3WvdXzheIlwdiCjdDCyNEB2VSCjZoTldkAyOiCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MkLhNlE3PTJ{MEi=

... Click to View More Cell Line Experimental Data

In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
Synonyms Sophoretin

Bio Calculators

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02989129 Not yet recruiting Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain M.D. Anderson Cancer Center March 2017 Early Phase 1
NCT02446795 Recruiting Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT02874989 Recruiting Idiopathic Pulmonary Fibrosis (IPF) Wake Forest University Health Sciences|Mayo Clinic August 2016 Phase 1
NCT02866448 Withdrawn Cardiovascular Disease University of Reading|Biotechnology and Biological Sciences Research Council|Quercegen Pharmaceuticals August 2016 --
NCT02848131 Recruiting Chronic Kidney Disease Mayo Clinic July 2016 Phase 2
NCT02652052 Recruiting Stem Cell Transplant Mayo Clinic March 2016 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID