Quercetin

Catalog No.S2391 Synonyms: Sophoretin

Quercetin Chemical Structure

Molecular Weight(MW): 302.24

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.

Size Price Stock Quantity  
USD 50 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

1 Customer Review

  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin purchased from Selleck.

Purity & Quality Control

Choose Selective Sirtuin Inhibitors

Biological Activity

Description Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
Targets
Sirtuin [4] Src [1] PKC [1] PI3Kγ [1]
(Cell-free assay)
PI3Kδ [1]
(Cell-free assay)
2.4 μM 3.0 μM
In vitro

Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1] Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 cells NHnVPWFHfW6ldHnvckBie3OjeR?= NInFdplKdmirYnn0bY9vKG:oIILheEBm[3SxLUWnMY52[2ynb4Tp[IF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIJ6KGOjcHnscIFzgSCnbHXjeJJweGixcnXzbZMhdWW2aH;kMEBMcT12NT6zJI5O MXqyNFE1PjR6Mx?=
RBL-1 cells MljPSpVv[3Srb36gZZN{[Xl? MlrhTY4hfmm2cn:gbY5pcWKrdHnvckBi\2GrboP0JFUudGmyb4j5[4Vv[XOnIHnuJHJDVC1zIHPlcIx{KHejczDk[ZRmem2rbnXkMEBKSzVyPUCuNkDPxE1? M1mzXlgzPTR4MkC=
HEK293 FS cells M4DvfWZ2dmO2aX;uJIF{e2G7 MUjJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTBwNkig{txO NWnqXnFPOjB5M{GzOVc>
RAW264.7 cells NEHkNVdHfW6ldHnvckBie3OjeR?= NV\HTpVSOjRiaB?= M{PwdWlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bi\nSncjCyOEBpenNuIFnDOVA:OS5|IN88US=> NVLkOmZtOjN3NEC5PFE>
human HeLa cells MUDGeY5kfGmxbjDhd5NigQ>? MmP3TY5pcWKrdHnvckBw\iCPUmCxJJRz[W6|ZnXjeIVlKGmwIHj1cYFvKEinTHGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCdM1jdUHREPCC2cnHud5BwenRiYomgdoFxcWRiZnnseJJifGmxbjDhd5NigSxiS3m9Nk41KM7:TR?= NGnTO2wyQTd{NUW3PC=>
HT22 cells MUHGeY5kfGmxbjDhd5NigQ>? MXjJcohq[mm2aX;uJI9nKGeudYThcYF1\S2rbnT1Z4VlKG:6eYTvd4l{KG:oIH3veZNmKGircIDvZ4FueGGuIFjUNlIh[2WubIOsJGVEPTB;Mj65PEDPxE1? NXzMbJo5OTZ|OUK4NVQ>
HT22 cells NVfMfItjTnWwY4Tpc44h[XO|YYm= NGnlTFFP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgbY4hdW:3c3WgTHQzOiClZXzsd{Bie3Onc4Pl[EBieyCycn;0[YN1cW:wIHHnZYlve3RiZ3z1eIFu[XSnLXnu[JVk\WRib4jp[IF1cX[nIHThcYFo\SCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCHQ{WwQVMvOTNizszN MWqyOFYxOjlyNB?=
NCI-H1792 cells NIfiVndHfW6ldHnvckBie3OjeR?= Ml\CRY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JOTd7MjDj[YxteyCkeTDIWHMh[XO|YYmsJGlEPTB;Mz64OUDPxE1? NEXkOWEzPTF|OUW2PS=>
human BV2 cells M{\mTWZ2dmO2aX;uJIF{e2G7 NX7XSVlmOjRiaB?= MUfJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25iaX6gbJVu[W5iQm[yJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCJcnnld5Mh[XO|YYmsJGlEPTB;ND6zJO69VQ>? NYHxclFVOjVzMkexOlQ>
human HTLA cells NF3SfoZHfW6ldHnvckBie3OjeR?= NHHjN5UzOCCvaX7z M4H0VWlvcGmkaYTpc44hd2ZiQ2izR2wyNXO2aX31cIF1\WRiQ2izR3IyKGmwIHj1cYFvKEiWTFGgZ4VtdHNicILlMYlv[3WkYYTl[EBnd3JiMkCgcYlveyCvZXHzeZJm\CCxbjDkZZkhPCCkeTDi[ZRiKGG{cnXzeIlvNXKnY4L1bZRu\W62IH3l[IlifGWmIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME20MlUh|ryP MkHkNlM1Ozd5N{K=
human LOXIMVI cells M4fhemZ2dmO2aX;uJIF{e2G7 NYHxdoNpSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGxQYEmPVlmgZ4VtdHNiYomgTHRUKGG|c3H5MEBKSzVyPUSuOlUh|ryP NInlfFkzPTF|OUW2PS=>
Jurkat T cells NETQXZlHfW6ldHnvckBie3OjeR?= MVHBZ5Rqfmm2eTDh[4FqdnO2IHj5[JJw\2WwIIDldo95cWSnIHnu[JVk\WRiRF7BJIRidWGpZTDpckBLfXKtYYSgWEBk\WyuczygTWM2OD13IN88US=> M37O[|E3Ozl{OEG0
human HCT116 cells M2\sN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2XWe|Q5KGh? M4qwdGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDFzNjDj[YxteyCxdnXy[ZhxemW|c3nu[{BRUTONYXzwbIEhUDFyNEfSJI12fGGwdDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTVwNzFOwG0> MWeyNlIyOjd{MR?=
human NCI-H522 cells NV;YcpNETnWwY4Tpc44h[XO|YYm= NX7ZN5dKSW62aXPhcoNmeiCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KNUKyJINmdGy|IHL5JGhVWyCjc4PhfUwhUUN3ME21Mlc4KM7:TR?= NYHjdY5vOjVzM{m1Olk>
human U2OS cells NVjKVldWTnWwY4Tpc44h[XO|YYm= NHi0UG5C\2:waYP0JIFkfGm4aYT5JIF1KEeSUkO1JJJm[2WydH;yJIlvKGi3bXHuJHUzV1NiY3XscJMh[2:neIDy[ZN{cW6pIFfhcFQuXlBzNj3USXYh[XO|ZYPz[YQh[XNiYnX0ZUBienKnc4TpckB1emGwc3zvZ4F1cW:wIHHmeIVzKDViaILzJIJ6KGKndHGgcIFkfGGvYYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9OU46OyEQvF2= MlzqNlQ6ODB2NEe=
human NCI-H157 cells M4jtXGZ2dmO2aX;uJIF{e2G7 MWLBcpRq[2GwY3XyJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyPTdiY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTZizszN MlftNlUyOzl3Nkm=
human A549 cells M1LJOGZ2dmO2aX;uJIF{e2G7 MnLORY51cWOjbnPldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZpkhUFSVIHHzd4F6NCCLQ{WwQVYvOiEQvF2= M2HERlI2OTN7NU[5
human HCT116 cells M3Th[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVLnUWR4PDhiaB?= NEnSOohIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF03NjdizszN MU[yNlIyOjd{MR?=
MDCK cells MUnGeY5kfGmxbjDhd5NigQ>? NITMS4RKdmirYnn0bY9vKG:oIFLDVnAh\XiycnXzd4VlKGmwIF3ER2sh[2WubIOgeZNqdmdiSH;lZ4h{fCB|M{O0NkB{fGGrbnnu[{whUUN3ME22Mlkh|ryP MXqyNVM2PDhyMB?=
human HOP62 cells M2PIU2Z2dmO2aX;uJIF{e2G7 NIDP[3RCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTG9RPjJiY3XscJMh[nliSGTTJIF{e2G7LDDJR|UxRTdwNUKg{txO MmXaNlUyOzl3Nkm=
human H460 cells MVPGeY5kfGmxbjDhd5NigQ>? NGWyb5BCdnSrY3HuZ4VzKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTFQ3OCClZXzsd{BjgSCKVGOgZZN{[XluIFnDOVA:QS54MjFOwG0> Mn\2NlUyOzl3Nkm=
human BV2 cells MXjGeY5kfGmxbjDhd5NigQ>? MmfDRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDCWlIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBvcXS{aXOgc5hq\GVicILv[JVkfGmxbjDifUBIemmnc4OgZZN{[XluIFnDOVA:OTBizszN NGTvWFkzPDdyN{mzPC=>
human MCF7 cells MmDiR5l1d3SxeHnjbZR6KGG|c3H5 MoG4O|IhcA>? NVTCXHBjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlAvQSEQvF2= NWXLb|QzOjV7ME[zPFU>
human 2008 cells MmLHR5l1d3SxeHnjbZR6KGG|c3H5 M13OdVczKGh? NVO0O5Y{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hOjByODDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlEvOThizszN NGe1bpEzPTlyNkO4OS=>
human A431 cells NGPm[HlEgXSxdH;4bYNqfHliYYPzZZk> MX[3NkBp M2rNSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKzMlA1KM7:TR?= NX60b5JpOjV7ME[zPFU>
human BxPC3 cells NHjtVWFEgXSxdH;4bYNqfHliYYPzZZk> NX:xWnQxPzJiaB?= MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCfHBEOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkSuNVIh|ryP NXO0XoQ5OjV7ME[zPFU>
human HepG2 cells NVjjOVQzS3m2b4TvfIlkcXS7IHHzd4F6 NYXQXVJJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyPUOwMlkh|ryP MnflNlE4OjZyN{e=
human MDA-MB-231 cells MorjSpVv[3Srb36gZZN{[Xl? NWXyNIppOjBizszN MlzPNVIhcA>? NXexZ4FnUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJINt\WG4ZXSgZ4F{eGG|ZT23JIFk[3WvdXzheIlwdiCjdDCyNEB2VSCjZoTldkAyOiCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NVPVW|hXOjF4NUKyNFg>

... Click to View More Cell Line Experimental Data

In vivo Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.[3] LD50: >3000mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (201.82 mM)
Ethanol 10 mg/mL (33.08 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.24
Formula

C15H10O7

CAS No. 117-39-5
Storage powder
in solvent
Synonyms Sophoretin

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02989129 Not yet recruiting Polyneuropathies and Other Disorders of the Peripheral Nervous System|Chemotherapy Induced Neuropathic Pain M.D. Anderson Cancer Center March 2017 Early Phase 1
NCT02446795 Recruiting Renal Cell Carcinoma|Kidney Cancer Consorzio Oncotech|Clinical Research Technology S.r.l.|Quercegen Pharmaceuticals November 2016 Phase 1|Phase 2
NCT02874989 Recruiting Idiopathic Pulmonary Fibrosis (IPF) Wake Forest University Health Sciences|Mayo Clinic August 2016 Phase 1
NCT02866448 Withdrawn Cardiovascular Disease University of Reading|Biotechnology and Biological Sciences Research Council|Quercegen Pharmaceuticals August 2016 --
NCT02848131 Recruiting Chronic Kidney Disease Mayo Clinic July 2016 Phase 2
NCT02652052 Recruiting Stem Cell Transplant Mayo Clinic March 2016 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Sirtuin Signaling Pathway Map

Related Sirtuin Products

Tags: buy Quercetin | Quercetin supplier | purchase Quercetin | Quercetin cost | Quercetin manufacturer | order Quercetin | Quercetin distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID