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Quercetin (Sophoretin) Chemical Structure
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Biological Activity
Quercetin (Sophoretin) is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. [1][2] Quercetin is a naturally-occurring polar auxin transport inhibitor with IC50 of 0.8, 16.7, 6.1, 11.36 µM for the inhibition of LDH% release, the inhibition of TNF-induced PMN-EC adhesion, TNF-induced inhibition of DNA synthesis and proliferation. It is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. [3]
References on Quercetin (Sophoretin)
- [1] Mol Pharmacol 2001;59:1138–1146
- [2] Fitoterapia 2010;81:75–80
Chemical Information
| Molecular Weight (WM): | 302.24 |
|---|---|
| Formula: | C15H10O7 |
| CAS No.: | 117-39-5 |
| Synonyms: |
Meletin, Quercetine
|
| Dissolve in (25°C): | DMSO ≥60mg/mL |
| Water <1mg/mL | |
| Ethanol ≥22mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
Data independently produced by Dr. Zhang of Tianjin Medical University Quercetin (Sophoretin) purchased from Selleck
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF. |
Data independently produced by Dr. Zhang of Tianjin Medical University
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