4-Methylumbelliferone (4-MU)

Catalog No.S2256

4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.

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In DMSO USD 90 In stock
USD 70 In stock
USD 210 In stock
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4-Methylumbelliferone (4-MU) Chemical Structure

4-Methylumbelliferone (4-MU) Chemical Structure
Molecular Weight: 176.17

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

4-Methylumbelliferone (4-MU) is available in the following compound libraries:

Product Information

Product Description

Biological Activity

4-Methylumbelliferone(4-MU) is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. 4-MU inhibited proliferation, motility, and invasion of DU145, PC3-ML, LNCaP, C4-2B, and/or LAPC-4 cells. At IC(50) for HA synthesis (0.4 mM), 4-MU induced >3-fold apoptosis in prostate cancer cells, which could be prevented by the addition of HA. The anticancer effects of 4-MU, an orally bioavailable and relatively nontoxic agent, are primarily mediated by inhibition of HA signaling. LD50: Mice 250mg/kg (i.v.), 325mg/kg (i.p.), >7500mg/kg (i.g.); Rats 750mg/kg (i.p.), 6200mg/kg (i.g.).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2015-06-27)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT00225537 Active, not recruiting Chronic Hepatitis C|Chronic Hepatitis B MTmedical Institute of Health|The University of Texas Hea  ...more MTmedical Institute of Health|The University of Texas Health Science Center at San Antonio|BioMonde Preparations Limited September 2005 Phase 2

Chemical Information

Download 4-Methylumbelliferone (4-MU) SDF
Molecular Weight (MW) 176.17
Formula

C10H8O3

CAS No. 90-33-5
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 35 mg/mL (198.67 mM)
Ethanol 35 mg/mL (198.67 mM)
Water <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 4-Methyl-7-hydroxycoumarin

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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