Name: Astaxanthin
Brand: Selleck Chemicals
SKU: S3834
Rating: 5 (4 reviews)

Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.

Astaxanthin Chemical Structure

CAS: 472-61-7

Selleck's Astaxanthin has been cited by 4 publications

Purity & Quality Control

Batch: Purity: 99.89%

99.89

Astaxanthin Related Products

Related Targets	PPARα PPARβ/δ PPARγ PPARδ	Click to Expand
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Signaling Pathway

PPAR Signaling Pathway

Choose Selective PPAR Inhibitors

Biological Activity

Description	Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.

In vitro
In vitro	Astaxanthin is a carotenoid nutrient with molecular properties that precisely position it within cell membranes and circulating lipoproteins, thereby imbuing them with potent antioxidant and anti-inflammatory actions. Astaxanthin also effectively protects the double membrane system of mitochondria, to the point of boosting their energy production efficiency. In cultured cells, astaxanthin protects the mitochondria against endogenous oxygen radicals, conserves their redox (antioxidant) capacity, and enhances their energy production efficiency. Astaxanthin has also protected human LDL against oxidative attack. Astaxanthin specifically protects the mitochondria of cultured nerve cells against toxic attack and stimulates the proliferation of cultured nerve stem cells. It effectively protects cultured nerve cells against hydrogen peroxide toxicity, and down-regulates genes linked to cell death and up-regulates genes linked to cell survival^[1].
Cell Research	Cell lines	Vero cells
	Concentrations	1, 5, 10, 20, or 30 μg/100 μL
	Incubation Time	24 h
	Method	Vero cells (5 × 10³/well) are seeded and cultured for 24 h and then infected with trypomastigotes (10 parasites/cell). Once intracellular parasites are observed (about 96 h after infection), the old medium is replaced with fresh supplemented DMEM with different ASTX (Astaxanthin) doses (1, 5, 10, 20, or 30 μg/100 μL). As a control, co-cultures are kept with NFMX (400 μg/100 μL) or with no ASTX or NFMX supplementation. After 24 h of incubation, microscopic morphological changes in the co-culture, such as loss of normal shape of T. cruzi infected Vero cell, changes of normal parasite shape or motility, and variations in the presence of intra- or extra-cellular parasites are evaluated by a trained technician. Additionally, parasite viability is evaluated by Trypan blue stain assay.

In Vivo
In vivo	In pharmacokinetic studies, after ingestion of esterified natural astaxanthin, only unesterified astaxanthin appears in the blood. Astaxanthin's bioavailability is substantially affected by meal timing and by smoking. Supplementation with astaxanthin may lower lipid peroxidation in vivo. Astaxanthin significantly improves the memory performance of mice in the Morris water maze. It has demonstrated safety in numerous human clinical trials. The doses of astaxanthin used in clinical trials have ranged from 1 mg/day to 40 mg/day (with the majority in the 6-12 mg range); single-dose pharmacokinetic studies use up to 100 mg per dose^[1].
Animal Research	Animal Models	BALB/c mice (4-6 weeks old) infected with Trypanosoma cruzi
	Dosages	10 mg/kg/day
	Administration	oral administration

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05138549	Terminated	Osteoarthritis Knee\|Osteoarthritis Knees Both\|Joint Inflammation	Prisma Health-Midlands	September 2 2022	Phase 2\|Phase 3
NCT05437601	Recruiting	Osteoarthritis Knee	Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh	July 2022	Phase 2
NCT05376501	Completed	Healthy	LycoRed Ltd.\|Nutrasource Pharmaceutical and Nutraceutical Services Inc.	June 8 2022	Not Applicable
NCT02343497	Completed	Dyslipidemias	Ajinomoto Foods Europe SAS\|Institut Polytechnique LaSalle Beauvais\|Naturalpha	August 2014	Not Applicable
NCT03945526	Completed	Cerebral Stroke\|Malondialdehyde\|Oxidative Stress	Indonesia University	March 23 2010	Phase 1

References

Chemical Information & Solubility

Molecular Weight	596.84	Formula	C₄₀H₅₂O₄
CAS No.	472-61-7	SDF	Download Astaxanthin SDF
Smiles	CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 6 mg/mL ( (10.05 mM)； Warmed with 50°C water bath; Ultrasonicated; Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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