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m6A (N6-methyladenosine)

Name: m6A (N6-methyladenosine)
Brand: Selleck Chemicals
SKU: S3190
Rating: 5 (20 reviews)

Synonyms: NSC-29409, 6-Methyladenosine, N-Methyladenosine

Catalog No.S3190 Purity: 99.79%

m6A (N6-methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.

m6A (N6-methyladenosine) Chemical Structure

CAS: 1867-73-8

Selleck's m6A (N6-methyladenosine) has been cited by 20 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 99.79%

99.79

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Signaling Pathway

DNA/RNA Synthesis Signaling Pathway

Choose Selective DNA/RNA Synthesis Inhibitors

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
adipocytes, heart and brain cells	Function assay				Affinity constant for inhibition of A1 receptor control of adenylate cyclase in adipocytes, heart and brain cells, Affinity constant=0.1μM	6279840
Click to View More Cell Line Experimental Data

Biological Activity

Description	m6A (N6-methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.

In vitro
In vitro	N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. It is also found in tRNA, rRNA, and small nuclear RNA(snRNA) as well as several long non-coding RNA, such as Xist. ^[1] ^[2] ^[3] N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA). ^[4] N6-Methyladenosine is a widespread RNA modification in many tissues with high levels in the brain. N6-Methyladenosine is enriched near stop codons and within 3’UTRs in both mouse and human mRNAs. ^[5] The recent discovery that FTO, an obesity risk gene, encodes an m6A demethylase implicates m6A as an important regulator of physiological processes. ^[6]

In Vivo
In vivo	LD50: Mice >1g/kg (i.g.). ^[7]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05682001	Recruiting	Cataract\|Pathogenesis	Eye & ENT Hospital of Fudan University\|National Natural Science Foundation of China	January 1 2022	--
NCT04696094	Recruiting	Moyamoya Disease	Beijing Tiantan Hospital	January 1 2021	--

References

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Chemical Information & Solubility

Molecular Weight	281.27	Formula	C₁₁H₁₅N₅O₄
CAS No.	1867-73-8	SDF	--
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 56 mg/mL ( (199.09 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 14 mg/mL

Ethanol : 9 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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