Home Proteases MMP inhibitor - p38 MAPK inhibitor - ERK inhibitor - JNK inhibitor Trans-Zeatin For research use only.

Trans-Zeatin

Synonyms: (E)-Zeatin

Trans-Zeatina ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. Trans-Zeatin inhibits UVB-induced MMP-1 expression, c-Jun activation and phosphorylation of ERK, JNK and p38 MAP kinases (MAPKs) dose-dependently.

Trans-Zeatin Chemical Structure

Trans-Zeatin Chemical Structure

CAS: 1637-39-4

Purity & Quality Control

Batch: S488401 DMSO] 43 mg/mL] false] Ethanol] 2 mg/mL] false] Water] Insoluble] false Purity: 99.96%
99.96

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Biological Activity

Description Trans-Zeatina ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. Trans-Zeatin inhibits UVB-induced MMP-1 expression, c-Jun activation and phosphorylation of ERK, JNK and p38 MAP kinases (MAPKs) dose-dependently.
Targets
MMP-1 [1] ERK [1] JNK [1] p38 MAPK [1]
In vitro
In vitro Pretreatment with trans-Zeatin significantly inhibits UVB-induced MMP-1 expression and c-Jun activation in a dose-dependent manner in cultured human skin fibroblasts, which may be mediated by inhibition of ERK, JNK and p38 MAPKs signaling pathways[1].
Cell Research Cell lines human skin fibroblasts (HSFs)
Concentrations 20, 40, 80, 150, 300, 600 μM
Incubation Time 24 h
Method HSFs are seeded in a 96-well plate. After various concentrations of trans-Zeatin or UVB treatment, cells are cultured in 100 μl 10% DMEM in each well for the indicated time. MTT solution (10 μl) at a concentration of 5 mg/ml is added to each well, and the cells are then incubated at 37˚C for 4 h. The medium is removed, and 200 μl of DMSO is added into each well to dissolve formazan crystals by pipetting up and down several times. The absorbance is measured spectrophotometrically on an ELISA plate reader at a wavelength of 570 nm.

Chemical Information & Solubility

Molecular Weight 219.24 Formula

C10H13N5O
CAS No. 1637-39-4 SDF --
Smiles CC(=CCNC1=NC=NC2=C1NC=N2)CO
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 43 mg/mL ( (196.13 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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