Home PI3K/Akt/mTOR mTOR activator L-Leucine For research use only.

L-Leucine

Synonyms: (S)-Leucine, Leu

Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

L-Leucine Chemical Structure

L-Leucine Chemical Structure

CAS: 61-90-5

Purity & Quality Control

Batch: Purity: 99.03%
99.03

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Biological Activity

Description Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
In vitro
In vitro Leucine also stimulates protein synthesis in muscle and is closely associated with the release of gluconeogenic precursors, such as alanine, from muscle[1].
In Vivo
In vivo Leucine has a half-life of 45 minutes[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06050668 Not yet recruiting
Femoral Fracture|Fragility Fracture|Muscle Atrophy
Michael C Willey|MEND|University of Iowa
 February 2024 Not Applicable
NCT06181734 Recruiting
Acute Myeloid Leukemia (AML)
iOMEDICO AG
 January 2024 --
NCT05621291 Not yet recruiting
B-All|Acute Lymphoblastic Leukemia
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 January 12 2024 Not Applicable
NCT06193902 Recruiting
Tumor Solid
Leucid Bio
 November 13 2023 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 131.17 Formula

C6H13NO2
CAS No. 61-90-5 SDF --
Smiles CC(C)CC(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 13 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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