Research Area
Product Type
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Asiatic acid Chemical Structure
SB 203580
SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM).
SB 202190
SB 202190 is a P38 MAP(mitogen activated protein) Kinase inhibitor.
VX-745
VX-745 is a potent and selective inhibitor to p38α and p38β MAPK with IC50 of 10 nM and 220 nM, respectively.
LY2228820
LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively).
Vinorelbine (Navelbine)
Vinorelbine (Navelbine) is the first 5´NOR semi-synthetic vinca alkaloid and exerts its activity through the MAPK (p38) pathway with median IC90 and IC50 of 15.5 and 2.3 μM.
BIRB 796 (Doramapimod)
BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor of TNF-α with EC50 of 18 nM in THP-1 cells.
PH-797804
PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM.
VX-702
VX-702 is a highly selective, orally active inhibitor of p38 MAPKα with an IC50 range of 4 to 20 nM for human platelets.
AZD6244 (Selumetinib)
AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.
CI-1040 (PD184352)
CI-1040 (PD184352) is a MEK 1/2 inhibitor. Ki of 300nM
Biological Activity
Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing. It is a neuroprotectant and inducer of apoptosis in HepG2 human hepatoma cells. It was likely to confine the breast cancer cells in the S-G2/M phase mainly through the p38 pathway, because both SB203580 and p38 small interfering RNA (siRNA) inhibition significantly attenuated the accumulation of inactive phospho-Cdc2 and phospho-Cdc25C proteins and the cell numbers of S-G2/M phase. [1]
References on Asiatic acid
- [1] J Pharmacol Exp Ther. 2005 Apr;313(1):333-44.
Product Information
| Molecular Weight (WM): | 488.70 |
|---|---|
| Formula: | C30H48O5 |
| CAS No.: | 464-92-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥98mg/mL |
| Water ≥4mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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