Immunology & Inflammation related

Inhibitory Selectivity
Solubility

Catalog No.	Product Name	Solubility(25°C)
Catalog No.	Product Name	Water	DMSO	Alcohol
S2286	Cyclosporin A	<1 mg/mL	100 mg/mL	100 mg/mL
S5004	Pimecrolimus	<1 mg/mL	100 mg/mL	100 mg/mL
S3032	Bindarit	<1 mg/mL	64 mg/mL	64 mg/mL
S1591	Bestatin	<1 mg/mL	0.4 mg/mL	<1 mg/mL
S8660	GI254023X	<1 mg/mL	78 mg/mL	78 mg/mL
S5661	Tiaprofenic acid	<1 mg/mL	52 mg/mL	52 mg/mL
S5412	Loxoprofen Sodium	53 mg/mL	<1 mg/mL	<1 mg/mL
S5361	Bendazac	<1 mg/mL	56 mg/mL	56 mg/mL
S5360	Diflorasone	<1 mg/mL	82 mg/mL	2 mg/mL
S5466	Saikosaponin A	<1 mg/mL	100 mg/mL	100 mg/mL
S7732	ISO-1	<1 mg/mL	47 mg/mL	47 mg/mL
S3778	Patchouli alcohol	-1 mg/mL	44 mg/mL	-1 mg/mL
S3892	Isopsoralen	-1 mg/mL	14 mg/mL	-1 mg/mL
S3758	Sinomenine hydrochloride	-1 mg/mL	73 mg/mL	-1 mg/mL
S3827	Royal jelly acid	-1 mg/mL	37 mg/mL	-1 mg/mL
S3680	NLRP3 Inflammasome Inhibitor I	<1 mg/mL	73 mg/mL	<1 mg/mL
S3622	Diammonium Glycyrrhizinate	100 mg/mL	100 mg/mL	<1 mg/mL
S3608	Demethylzeylasteral (T-96)	<1 mg/mL	96 mg/mL	33 mg/mL
S1622	Prednisone	<1 mg/mL	71 mg/mL	<1 mg/mL
S1514	Cyclosporine	<1 mg/mL	100 mg/mL	100 mg/mL
S1576	Sulfasalazine	<1 mg/mL	80 mg/mL	<1 mg/mL
S1654	Phenylbutazone	<1 mg/mL	62 mg/mL	62 mg/mL
S2512	Tenoxicam	<1 mg/mL	68 mg/mL	<1 mg/mL
S4268	Flufenamic acid	<1 mg/mL	56 mg/mL	56 mg/mL
S7809	MCC950(CP-456773)	85 mg/mL	<1 mg/mL	40 mg/mL
S8291	Atractylenolide I	<1 mg/mL	46 mg/mL	46 mg/mL
S8522	Compstatin	100 mg/mL	-1 mg/mL	-1 mg/mL
S4753	Ganoderic acid A	<1 mg/mL	100 mg/mL	100 mg/mL
S7434	TAPI-1	60 mg/mL	99 mg/mL	99 mg/mL
S1829	Pranlukast	<1 mg/mL	11 mg/mL	<1 mg/mL
S7211	PF-04418948	<1 mg/mL	81 mg/mL	<1 mg/mL
S3726	Selexipag	<1 mg/mL	99 mg/mL	49 mg/mL
S1407	Bimatoprost	<1 mg/mL	36 mg/mL	83 mg/mL
S1508	Alprostadil	<1 mg/mL	71 mg/mL	71 mg/mL
S4529	Idramantone	33 mg/mL	33 mg/mL	33 mg/mL
S2286	Cyclosporin A	<1 mg/mL	100 mg/mL	100 mg/mL
S5004	Pimecrolimus	<1 mg/mL	100 mg/mL	100 mg/mL
S3032	Bindarit	<1 mg/mL	64 mg/mL	64 mg/mL
S1591	Bestatin	<1 mg/mL	0.4 mg/mL	<1 mg/mL
S8660	GI254023X	<1 mg/mL	78 mg/mL	78 mg/mL
S5661	Tiaprofenic acid	<1 mg/mL	52 mg/mL	52 mg/mL
S5412	Loxoprofen Sodium	53 mg/mL	<1 mg/mL	<1 mg/mL
S5361	Bendazac	<1 mg/mL	56 mg/mL	56 mg/mL
S5360	Diflorasone	<1 mg/mL	82 mg/mL	2 mg/mL
S5466	Saikosaponin A	<1 mg/mL	100 mg/mL	100 mg/mL
S7732	ISO-1	<1 mg/mL	47 mg/mL	47 mg/mL
S3778	Patchouli alcohol	-1 mg/mL	44 mg/mL	-1 mg/mL
S3892	Isopsoralen	-1 mg/mL	14 mg/mL	-1 mg/mL
S3758	Sinomenine hydrochloride	-1 mg/mL	73 mg/mL	-1 mg/mL
S3827	Royal jelly acid	-1 mg/mL	37 mg/mL	-1 mg/mL
S3680	NLRP3 Inflammasome Inhibitor I	<1 mg/mL	73 mg/mL	<1 mg/mL
S3622	Diammonium Glycyrrhizinate	100 mg/mL	100 mg/mL	<1 mg/mL
S3608	Demethylzeylasteral (T-96)	<1 mg/mL	96 mg/mL	33 mg/mL
S1622	Prednisone	<1 mg/mL	71 mg/mL	<1 mg/mL
S1514	Cyclosporine	<1 mg/mL	100 mg/mL	100 mg/mL
S1576	Sulfasalazine	<1 mg/mL	80 mg/mL	<1 mg/mL
S1654	Phenylbutazone	<1 mg/mL	62 mg/mL	62 mg/mL
S2512	Tenoxicam	<1 mg/mL	68 mg/mL	<1 mg/mL
S4268	Flufenamic acid	<1 mg/mL	56 mg/mL	56 mg/mL
S7809	MCC950(CP-456773)	85 mg/mL	<1 mg/mL	40 mg/mL
S8291	Atractylenolide I	<1 mg/mL	46 mg/mL	46 mg/mL
S8522	Compstatin	100 mg/mL	-1 mg/mL	-1 mg/mL
S4753	Ganoderic acid A	<1 mg/mL	100 mg/mL	100 mg/mL
S7434	TAPI-1	60 mg/mL	99 mg/mL	99 mg/mL
S1211	Imiquimod	<1 mg/mL	1 mg/mL	<1 mg/mL
s9019	Quillaic acid		97 mg/mL
s9022	20S-Ginsenoside Rg3		100 mg/mL
s9023	20S-Ginsenoside Rh2		100 mg/mL
s9025	AtractylenolideI		46 mg/mL
S5737	Diclofenac Epolamine	82 mg/mL	82 mg/mL	82 mg/mL
S5674	Lodoxamide Tromethamine	19 mg/mL	<1 mg/mL	<1 mg/mL
S5501	Hydrocortisone acetate	-1 mg/mL	80 mg/mL	-1 mg/mL
S5500	Amodiaquine hydrochloride	-1 mg/mL	56 mg/mL	-1 mg/mL
S3969	Veratric acid	-1 mg/mL	36 mg/mL	-1 mg/mL
S5322	Sodium gualenate	18 mg/mL	60 mg/mL	1 mg/mL
S5579	Chelidonic acid	-1 mg/mL	4 mg/mL	-1 mg/mL
S5451	Ferulic acid methyl ester	41 mg/mL	41 mg/mL	41 mg/mL
S5457	Curculigoside	15 mg/mL	93 mg/mL	93 mg/mL
S5458	Verbascoside	100 mg/mL	100 mg/mL	23 mg/mL
S5459	Aucubin	15 mg/mL	69 mg/mL	<1 mg/mL
S5463	Curcurbitacin IIA	<1 mg/mL	100 mg/mL	5 mg/mL
S5471	Monotropein	78 mg/mL	78 mg/mL	<1 mg/mL
S5517	Fenamic acid	-1 mg/mL	42 mg/mL	-1 mg/mL
S3776	Sophoricoside	<1 mg/mL	86 mg/mL	<1 mg/mL
S5043	Benorylate	-1 mg/mL	62 mg/mL	-1 mg/mL
S5016	Isoprinosine	100 mg/mL	100 mg/mL	2 mg/mL
S5044	Isoxepac	<1 mg/mL	53 mg/mL	53 mg/mL
S5046	Clonixin	<1 mg/mL	52 mg/mL	15 mg/mL
S4966	4-Methylesculetin	-1 mg/mL	38 mg/mL	-1 mg/mL
S4832	Tolmetin	-1 mg/mL	51 mg/mL	-1 mg/mL
S4835	Aceclofenac	-1 mg/mL	70 mg/mL	-1 mg/mL
S3997	Oxaceprol	-1 mg/mL	34 mg/mL	-1 mg/mL
S4789	5-Acetylsalicylic acid	-1 mg/mL	36 mg/mL	-1 mg/mL
S5157	Thymol	-1 mg/mL	30 mg/mL	-1 mg/mL
S3982	Batyl alcohol	-1 mg/mL	68 mg/mL	-1 mg/mL
S3906	Astragalus polyphenols	-1 mg/mL	81 mg/mL	-1 mg/mL
S3877	Lysionotin	-1 mg/mL	68 mg/mL	-1 mg/mL
S3881	Scopoletin	-1 mg/mL	38 mg/mL	-1 mg/mL
S3790	Methyl gallate	-1 mg/mL	36 mg/mL	-1 mg/mL
S3799	Gentisic acid	-1 mg/mL	30 mg/mL	-1 mg/mL
S3765	Picroside II	-1 mg/mL	100 mg/mL	-1 mg/mL
S3774	Dehydroandrographolide Succinate Potasium Salt	-1 mg/mL	10 mg/mL	-1 mg/mL
S3775	Ligustrazine hydrochloride	-1 mg/mL	34 mg/mL	-1 mg/mL
S3932	Astilbin	-1 mg/mL	100 mg/mL	-1 mg/mL
S3837	Echinocystic acid	-1 mg/mL	94 mg/mL	-1 mg/mL
S3824	Quercitrin	-1 mg/mL	89 mg/mL	-1 mg/mL
S3841	Eleutheroside B	-1 mg/mL	74 mg/mL	-1 mg/mL
S3956	Tetramethylpyrazine	-1 mg/mL	27 mg/mL	-1 mg/mL
S3614	Lupeol	<1 mg/mL	1 mg/mL	<1 mg/mL
S3685	4-Biphenylacetic acid	<1 mg/mL	42 mg/mL	42 mg/mL
S3745	Balsalazide disodium	87 mg/mL	87 mg/mL	<1 mg/mL
S1439	Tranilast	<1 mg/mL	66 mg/mL	<1 mg/mL
S4169	Teriflunomide	<1 mg/mL	32 mg/mL	,1 mg/mL
S2413	Geniposidic acid	<1 mg/mL	16 mg/mL	2 mg/mL
S1939	Levamisole hydrochloride	48 mg/mL	<1 mg/mL	<1 mg/mL
S1681	Mesalamine	<1 mg/mL	31 mg/mL	31 mg/mL
S2910	Tempol	34 mg/mL	34 mg/mL	34 mg/mL
S1679	Flurbiprofen	<1 mg/mL	49 mg/mL	49 mg/mL
S3062	Diclofenac Potassium	10 mg/mL	69 mg/mL	<1 mg/mL
S4098	Halcinonide	<1 mg/mL	90 mg/mL	4 mg/mL
S1823	Fenoprofen Calcium	<1 mg/mL	105 mg/mL	10 mg/mL
S4152	Ethamsylate	53 mg/mL	53 mg/mL	<1 mg/mL
S2383	Gastrodin	<1 mg/mL	50 mg/mL	<1 mg/mL
S2387	Lappaconite HBr	<1 mg/mL	28 mg/mL	<1 mg/mL
S4165	Benzydamine HCl	69 mg/mL	69 mg/mL	69 mg/mL
S4170	Coumarin	<1 mg/mL	29 mg/mL	29 mg/mL
S2400	Rheic Acid	<1 mg/mL	<1 mg/mL	<1 mg/mL
S4188	Sasapyrine	<1 mg/mL	52 mg/mL	52 mg/mL
S7448	CORM-3	<1 mg/mL	38 mg/mL	<1 mg/mL
S4682	Loxoprofen	<1 mg/mL	49 mg/mL	49 mg/mL
S8141	Cl-amidine	70 mg/mL	84 mg/mL	84 mg/mL
S3027	Fenoprofen calcium hydrate	<1 mg/mL	48 mg/mL	18 mg/mL
S8097	C-DIM12	<1 mg/mL	71 mg/mL	71 mg/mL
S2350	Rutin	<1 mg/mL	100 mg/mL	2 mg/mL
S3106	Pidotimod	10 mg/mL	49 mg/mL	<1 mg/mL
S4515	Ademetionine disulfate tosylate	79 mg/mL	79 mg/mL	<1 mg/mL
S4690	Escin	<1 mg/mL	66 mg/mL	<1 mg/mL

Immunology & Inflammation related Inhibitors (153)
New Immunology & Inflammation related Products

Catalog No.	Information	Product Use Citations	Product Validations
A2009^New	Rituximab Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.
A2001	Ipilimumab Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.
S2286	Cyclosporin A Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.	Oncogene, 2015, 10.1038/onc.2015.32 Antiviral Res, 2015, 120:140-6 Biochim Biophys Acta, 2013, 1833(3):652-62	Repression of BSEP gene expression upon treatment with reported BSEP inhibitors in human primary hepatocytes. BSEP mRNA expression was measured using real-time PCR in hepatocytes from at least three donors upon treatment with BSEP inhibitors as described under Materials and Methods. All the data are expressed as mean ?S.D. (n = 3).
S5004	Pimecrolimus Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.	Mol Pharmaco, 2013, 84(1):104-13 Am J Physiol Heart Circ Physiol, 2013, 305(11):H1646-57	Pim inhibits nuclear factor of activated T-cell (NFAT) translocation of cultured human vascular smooth muscle cells. hCASM expressing green fluorescent protein-NFAT were incubated with 10 uM Pim for 30 min. Left: mean nuclear/cytosol fluorescence intensity ratio (±SE) is displayed at basal conditions and after stimulation with 500 uM ATP in the absence and presence of Pim.
S3032	Bindarit Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.	Neurobiol Dis, 2014, 71C:292-304 Am J Transl Res, 2016, 8(1):28-36	Differential participation of ATRs or MCP-1/CCR2 signaling in RVLM in pressor response and tachycardia after stroke. Changes in mean diastolic (ΔDBP) blood pressure or heart rate (ΔHR) relative to baseline in rats that received pretreatment by microinjection bilaterally into the RVLM of bindarit (Bin; 10 nmol, MCP-1 synthesis inhibitor), BMS CCR2 22 (BMS; 10 pmol, CCR2 antagonist), propagermanium (Prop; 10 pmol, CCR2 antagonist) or vehicle control (Veh).Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus SC group, and +P < 0.05 versus Veh (Saline) + MCAO group in the post hoc Scheffe multiple-range test.
S1591	Bestatin Bestatin is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.	PLoS One, 2015, 10(11):e0142124	The aminopeptidase-N inhibitor, bestatin (C), showed an inhibitory effect on cell proliferation that predominated in mixed-IHCCA. *p< 0.05 mucin vs mixed, N experiments = 5-7.
S8660^New	GI254023X GI254023X is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.
S5661^New	Tiaprofenic acid Tiaprofenic acid is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.
S5412^New	Loxoprofen Sodium Loxoprofen sodium is a non-steroidal anti-inflammatory drug.
S5361^New	Bendazac Bendazac is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.
S5360^New	Diflorasone Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.
S5466^New	Saikosaponin A Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inﬂammatory, immunomodulatory, and anti-bacterial activities.
S7732^New	ISO-1 ISO-1 is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.
S3778^New	Patchouli alcohol Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
S3892^New	Isopsoralen Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
S3758^New	Sinomenine hydrochloride Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.
S3827^New	Royal jelly acid Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.
S3680^New	NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
S3622^New	Diammonium Glycyrrhizinate Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
S3608^New	Demethylzeylasteral (T-96) Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.
S1622	Prednisone Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
S1514	Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
S1576	Sulfasalazine Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis.
S1654	Phenylbutazone Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
S2512	Tenoxicam Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.
S4268	Flufenamic acid Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
S8559	INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
S7809	MCC950(CP-456773) MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.	Arthritis Rheumatol , 2017, 69(8):1636-1646	A-C, Expression of caspase 1 and its active form caspase 1-p20, as demonstrated in representative Western blots (top) and the relative expression levels (B and C) in each group.
S8291	Atractylenolide I Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.
S8522	Compstatin Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.
S4753	Ganoderic acid A Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.
S7434	TAPI-1 TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.	PLoS One, 2017, 12(3):e0173240 Sci Rep, 2017, 7:46315	(B) Florescent images of EpEX (green) and EpICD (red) in PK-15 cells, which were transfected by pSIN-fEpCAM-mCherry and treated with or without TAPI-1/DAPT. Nuclei were stained by Hoechst 33342 (blue). Scale bar, 25 μm.
S1829	Pranlukast Pranlukast is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.
S7211	PF-04418948 PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.
S3726^New	Selexipag Selexipag is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).
S1407	Bimatoprost Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
S1508	Alprostadil Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.
S4529	Idramantone Idramantone is an immune agonist.
S4709	Latanoprost Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
A2009^New	Rituximab Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.
A2001	Ipilimumab Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.
S2286	Cyclosporin A Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.	Oncogene, 2015, 10.1038/onc.2015.32 Antiviral Res, 2015, 120:140-6 Biochim Biophys Acta, 2013, 1833(3):652-62	Repression of BSEP gene expression upon treatment with reported BSEP inhibitors in human primary hepatocytes. BSEP mRNA expression was measured using real-time PCR in hepatocytes from at least three donors upon treatment with BSEP inhibitors as described under Materials and Methods. All the data are expressed as mean ?S.D. (n = 3).
S5004	Pimecrolimus Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.	Mol Pharmaco, 2013, 84(1):104-13 Am J Physiol Heart Circ Physiol, 2013, 305(11):H1646-57	Pim inhibits nuclear factor of activated T-cell (NFAT) translocation of cultured human vascular smooth muscle cells. hCASM expressing green fluorescent protein-NFAT were incubated with 10 uM Pim for 30 min. Left: mean nuclear/cytosol fluorescence intensity ratio (±SE) is displayed at basal conditions and after stimulation with 500 uM ATP in the absence and presence of Pim.
S3032	Bindarit Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.	Neurobiol Dis, 2014, 71C:292-304 Am J Transl Res, 2016, 8(1):28-36	Differential participation of ATRs or MCP-1/CCR2 signaling in RVLM in pressor response and tachycardia after stroke. Changes in mean diastolic (ΔDBP) blood pressure or heart rate (ΔHR) relative to baseline in rats that received pretreatment by microinjection bilaterally into the RVLM of bindarit (Bin; 10 nmol, MCP-1 synthesis inhibitor), BMS CCR2 22 (BMS; 10 pmol, CCR2 antagonist), propagermanium (Prop; 10 pmol, CCR2 antagonist) or vehicle control (Veh).Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus SC group, and +P < 0.05 versus Veh (Saline) + MCAO group in the post hoc Scheffe multiple-range test.
S1591	Bestatin Bestatin is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.	PLoS One, 2015, 10(11):e0142124	The aminopeptidase-N inhibitor, bestatin (C), showed an inhibitory effect on cell proliferation that predominated in mixed-IHCCA. *p< 0.05 mucin vs mixed, N experiments = 5-7.
S8660^New	GI254023X GI254023X is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.
S5661^New	Tiaprofenic acid Tiaprofenic acid is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.
S5412^New	Loxoprofen Sodium Loxoprofen sodium is a non-steroidal anti-inflammatory drug.
S5361^New	Bendazac Bendazac is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.
S5360^New	Diflorasone Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.
S5466^New	Saikosaponin A Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inﬂammatory, immunomodulatory, and anti-bacterial activities.
S7732^New	ISO-1 ISO-1 is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.
S3778^New	Patchouli alcohol Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
S3892^New	Isopsoralen Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
S3758^New	Sinomenine hydrochloride Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.
S3827^New	Royal jelly acid Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.
S3680^New	NLRP3 Inflammasome Inhibitor I NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
S3622^New	Diammonium Glycyrrhizinate Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
S3608^New	Demethylzeylasteral (T-96) Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.
S1622	Prednisone Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
S1514	Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
S1576	Sulfasalazine Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis.
S1654	Phenylbutazone Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
S2512	Tenoxicam Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.
S4268	Flufenamic acid Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
S8559	INF39 INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
S7809	MCC950(CP-456773) MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.	Arthritis Rheumatol , 2017, 69(8):1636-1646	A-C, Expression of caspase 1 and its active form caspase 1-p20, as demonstrated in representative Western blots (top) and the relative expression levels (B and C) in each group.
S8291	Atractylenolide I Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.
S8522	Compstatin Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.
S4753	Ganoderic acid A Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.
S7434	TAPI-1 TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.	PLoS One, 2017, 12(3):e0173240 Sci Rep, 2017, 7:46315	(B) Florescent images of EpEX (green) and EpICD (red) in PK-15 cells, which were transfected by pSIN-fEpCAM-mCherry and treated with or without TAPI-1/DAPT. Nuclei were stained by Hoechst 33342 (blue). Scale bar, 25 μm.
S1211	Imiquimod Imiquimod is a novel synthetic agent with immune response modifying activity.
s9019^New	Quillaic acid
s9022^New	20S-Ginsenoside Rg3 20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities.
s9023^New	20S-Ginsenoside Rh2 20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis.
s9025^New	AtractylenolideI Atractylenolide I (ATL-I) is a bioactive component of Rhizoma Atractylodis macrocephalae and shows anti-inflammatory effects.
S5737^New	Diclofenac Epolamine Diclofenac Epolamine is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.
S5674^New	Lodoxamide Tromethamine Lodoxamide Tromethamine is the tromethamide salt form of lodoxamide, a synthetic mast cell stabilizing compound with anti-inflammatory activity.
S5648^New	Iguratimod Iguratimod is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis.
S5501^New	Hydrocortisone acetate Hydrocortisone Acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
S5500^New	Amodiaquine hydrochloride Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
S3969^New	Veratric acid Veratric acid, a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects.
S5322^New	Sodium gualenate Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound, which is gradually decomposed in the solid state at room temperature. It has anti-inflammatory and wound-healing effects.
S5579^New	Chelidonic acid Chelidonic acid is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals.
S5451^New	Ferulic acid methyl ester Methyl ferulate is a lipophilic derivative of ferulic acid, which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.
S5457^New	Curculigoside Curculigoside, a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects.
S5458^New	Verbascoside Verbascoside, a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.
S5459^New	Aucubin Aucubin, an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.
S5463^New	Curcurbitacin IIA Cucurbitacin IIa (CuIIa) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects.
S5471^New	Monotropein Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity.
S5517^New	Fenamic acid Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.
S5261^New	Ufenamate Ufenamate is an anthranilic acid derivative with anti-inflammatory activity.
S5318^New	Acacetin Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
S3776^New	Sophoricoside Sophoricoside (SOPH) is an isoflavone isolated from Sophora japonica (Leguminosae) with numerous pharmacological effects, including anti- inflammatory, anti-cancer and immunosuppressive effects.
S5043^New	Benorylate Benorylate is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
S5016^New	Isoprinosine Isoprinosine is an immunopharmacologic agent with antiviral activities.
S5044^New	Isoxepac Isoxepac is a non-steroidal arylacetic acid derivative with anti-inflammatory, analgesic and antipyretic activity.
S5046^New	Clonixin Clonixin is a nonsteroidal anti-inflammatory drug with analgesic, antipyretic, and platelet-inhibitory actions.
S4966^New	4-Methylesculetin 4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.
S4832^New	Tolmetin Tolmetin is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.
S4835^New	Aceclofenac Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.
S3997^New	Oxaceprol Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.
S4789^New	5-Acetylsalicylic acid 5-Acetylsalicylic acid is a nonsteroidal anti-inflammatory drug.
S5157^New	Thymol Thymol, a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.
S3982^New	Batyl alcohol Batyl alcohol, isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.
S3906^New	Astragalus polyphenols Astragalus is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions.
S3877^New	Lysionotin Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.
S3881^New	Scopoletin Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.
S3813^New	Bakuchiol Bakuchiol is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
S3790^New	Methyl gallate Methyl Gallate is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.
S3799^New	Gentisic acid Gentisic acid, an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.
S3765^New	Picroside II Picroside II is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
S3774^New	Dehydroandrographolide Succinate Potasium Salt Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
S3775^New	Ligustrazine hydrochloride Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
S3932^New	Astilbin Astilbin, a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
S3871^New	Muscone Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent.
S3837^New	Echinocystic acid Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.
S3893^New	Bornyl acetate Bornyl acetate, the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.
S3824^New	Quercitrin Quercitrin (3-rhamnosyl quercetin), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.
S3841^New	Eleutheroside B Eleutheroside B (syringin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.
S3761^New	Eucalyptol Eucalyptol is a natural organic compound which controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.
S3956^New	Tetramethylpyrazine Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
S3614^New	Lupeol Lupeol is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.
S3685^New	4-Biphenylacetic acid 4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.
S3745^New	Balsalazide disodium Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine.
S1439	Tranilast Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.	Environ Toxicol Pharmacol, 2015, 39(1):114-24	Cells were cultured in LD collagen gels ± vehicle control (V), 100 M DFOM (D) or tranilast (T) for 24h (E-H) and assessed for P450 enzyme production.
S4169	Teriflunomide Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.
S2413	Geniposidic acid Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.
S1939	Levamisole hydrochloride Levamisole, also known as (-)-Tetramisole, is an inhibitor of alkaline phosphatase, used as an anthelmintic.
S1681	Mesalamine Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.
S2910	Tempol Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
S1679	Flurbiprofen Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).
S3062	Diclofenac Potassium Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
S4098	Halcinonide Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
S1823	Fenoprofen Calcium Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
S4152	Ethamsylate Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
S2383	Gastrodin Gastrodin, an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
S2387	Lappaconite HBr Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.
S4165	Benzydamine HCl Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
S4170	Coumarin Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.
S2400	Rheic Acid Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities.
S4188	Sasapyrine Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent.
S7448	CORM-3 CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
S4682	Loxoprofen Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
S8141	Cl-amidine Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively.
S3027	Fenoprofen calcium hydrate Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).
S4706	Eugenol Eugenol is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.
S8097	C-DIM12 C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
S2350	Rutin Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.
S3106	Pidotimod Pidotimod is an immunostimulant.
S4515	Ademetionine disulfate tosylate Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.
S4690	Escin Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).
S4524	2-Ethoxybenzamide 2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.

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