Immunology & Inflammation related
- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S2286||Cyclosporin A||<1 mg/mL||100 mg/mL||100 mg/mL|
|S5004||Pimecrolimus||<1 mg/mL||100 mg/mL||100 mg/mL|
|S3032||Bindarit||<1 mg/mL||64 mg/mL||64 mg/mL|
|S1591||Bestatin||<1 mg/mL||0.4 mg/mL||<1 mg/mL|
|S5774||CY-09||<1 mg/mL||85 mg/mL||<1 mg/mL|
|S9032||Sanguinarine||-1 mg/mL||44 mg/mL||-1 mg/mL|
|S5609||Chicago Sky Blue 6B||-1 mg/mL||20 mg/mL||-1 mg/mL|
|S5640||Ethyl caffeate||-1 mg/mL||41 mg/mL||-1 mg/mL|
|s9138||Picfeltarraenin IA||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9148||Peiminine||-1 mg/mL||85.9 mg/mL||-1 mg/mL|
|S9090||Corilagin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9106||Eleutheroside E||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9055||Salvianolic acid A||-1 mg/mL||98 mg/mL||-1 mg/mL|
|s9064||Trilobatin||-1 mg/mL||87 mg/mL||-1 mg/mL|
|s9072||Sweroside||-1 mg/mL||71 mg/mL||-1 mg/mL|
|S8660||GI254023X||<1 mg/mL||78 mg/mL||78 mg/mL|
|S5661||Tiaprofenic acid||<1 mg/mL||52 mg/mL||52 mg/mL|
|S5412||Loxoprofen Sodium||53 mg/mL||<1 mg/mL||<1 mg/mL|
|S5361||Bendazac||<1 mg/mL||56 mg/mL||56 mg/mL|
|S5360||Diflorasone||<1 mg/mL||82 mg/mL||2 mg/mL|
|S5466||Saikosaponin A||<1 mg/mL||100 mg/mL||100 mg/mL|
|S7732||ISO-1||<1 mg/mL||47 mg/mL||47 mg/mL|
|S3778||Patchouli alcohol||-1 mg/mL||44 mg/mL||-1 mg/mL|
|S3892||Isopsoralen||-1 mg/mL||14 mg/mL||-1 mg/mL|
|S1622||Prednisone||<1 mg/mL||71 mg/mL||<1 mg/mL|
|S1514||Cyclosporine||<1 mg/mL||100 mg/mL||100 mg/mL|
|S1576||Sulfasalazine||<1 mg/mL||80 mg/mL||<1 mg/mL|
|S1654||Phenylbutazone||<1 mg/mL||62 mg/mL||62 mg/mL|
|S2512||Tenoxicam||<1 mg/mL||68 mg/mL||<1 mg/mL|
|S3608||Demethylzeylasteral (T-96)||<1 mg/mL||96 mg/mL||33 mg/mL|
|S3622||Diammonium Glycyrrhizinate||100 mg/mL||100 mg/mL||<1 mg/mL|
|S4268||Flufenamic acid||<1 mg/mL||56 mg/mL||56 mg/mL|
|S3827||Royal jelly acid||-1 mg/mL||37 mg/mL||-1 mg/mL|
|S7809||MCC950(CP-456773)||85 mg/mL||<1 mg/mL||40 mg/mL|
|S3758||Sinomenine hydrochloride||-1 mg/mL||73 mg/mL||-1 mg/mL|
|S8291||Atractylenolide I||<1 mg/mL||46 mg/mL||46 mg/mL|
|S8522||Compstatin||100 mg/mL||-1 mg/mL||-1 mg/mL|
|S4753||Ganoderic acid A||<1 mg/mL||100 mg/mL||100 mg/mL|
|S7434||TAPI-1||60 mg/mL||99 mg/mL||99 mg/mL|
|S3680||NLRP3 Inflammasome Inhibitor I||<1 mg/mL||73 mg/mL||<1 mg/mL|
|S9174||Xanthotoxol||-1 mg/mL||40 mg/mL||-1 mg/mL|
|S5753||Setipiprant(ACT-129968, KYTH-105)||-1 mg/mL||80 mg/mL||-1 mg/mL|
|S1829||Pranlukast||<1 mg/mL||11 mg/mL||<1 mg/mL|
|S7211||PF-04418948||<1 mg/mL||81 mg/mL||<1 mg/mL|
|S5819||MRE-269(ACT-333679)||<1 mg/mL||84 mg/mL||<1 mg/mL|
|S1407||Bimatoprost||<1 mg/mL||36 mg/mL||83 mg/mL|
|S1508||Alprostadil||<1 mg/mL||71 mg/mL||71 mg/mL|
|S4529||Idramantone||33 mg/mL||33 mg/mL||33 mg/mL|
|S3726||Selexipag||<1 mg/mL||99 mg/mL||49 mg/mL|
|s9100||Fraxinellone||-1 mg/mL||46 mg/mL||-1 mg/mL|
|S5039||Actarit||-1 mg/mL||38 mg/mL||-1 mg/mL|
|S1737||Prednisolone||<1 mg/mL||72 mg/mL||10 mg/mL|
|S1733||Methylprednisolone||<1 mg/mL||75 mg/mL||2 mg/mL|
|S2787||Laquinimod||<1 mg/mL||61 mg/mL||1 mg/mL|
|S7515||VGX-1027||<1 mg/mL||41 mg/mL||41 mg/mL|
|S8301||AS101||<1 mg/mL||62 mg/mL||<1 mg/mL|
|S3648||Amlexanox||<1 mg/mL||59 mg/mL||1 mg/mL|
|S3668||Thymopentin||100 mg/mL||100 mg/mL||<1 mg/mL|
|S7516||Y-320||<1 mg/mL||11 mg/mL||<1 mg/mL|
|S1211||Imiquimod||<1 mg/mL||1 mg/mL||<1 mg/mL|
|S5834||p-Coumaric acid ethyl ester||<1 mg/mL||38 mg/mL||38 mg/mL|
|S5804||N-Acetylcysteine amide||32 mg/mL||32 mg/mL||13 mg/mL|
|S5729||Fosfosal||-1 mg/mL||43 mg/mL||-1 mg/mL|
|S9035||Isovitexin||-1 mg/mL||86 mg/mL||-1 mg/mL|
|S9036||(20R)Ginsenoside Rh2||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9037||Tenacissoside H||<1 mg/mL||100 mg/mL||32 mg/mL|
|S9038||Calycosin||<1 mg/mL||57 mg/mL||<1 mg/mL|
|S9005||Stearyl Glycyrrhetinate||<1 mg/mL||<1 mg/mL||100 mg/mL|
|S5686||Tryptanthrin||-1 mg/mL||8 mg/mL||-1 mg/mL|
|S9220||Stylopine hydrochloride||-1 mg/mL||5 mg/mL||-1 mg/mL|
|S9264||Decursin||-1 mg/mL||66 mg/mL||-1 mg/mL|
|S9439||Kaurenoic acid||-1 mg/mL||60 mg/mL||-1 mg/mL|
|S9440||Naringenin chalcone||-1 mg/mL||54 mg/mL||-1 mg/mL|
|S9502||Madecassic acid||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9384||Sophocarpine Monohydrate||-1 mg/mL||52 mg/mL||-1 mg/mL|
|S9405||Sesamoside||-1 mg/mL||84 mg/mL||-1 mg/mL|
|S9406||Sauchinone||-1 mg/mL||27 mg/mL||-1 mg/mL|
|S9407||Angoroside C||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9408||Beta-Elemonic acid||-1 mg/mL||35 mg/mL||-1 mg/mL|
|S9411||Liensinine||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9417||Homoplantaginin||-1 mg/mL||92 mg/mL||-1 mg/mL|
|S9425||Trifolirhizin||-1 mg/mL||89 mg/mL||-1 mg/mL|
|S9427||Tabersonine||-1 mg/mL||67 mg/mL||-1 mg/mL|
|S9430||Tomatidine||-1 mg/mL||5 mg/mL||-1 mg/mL|
|S9431||Dehydrocorydalin||-1 mg/mL||73 mg/mL||-1 mg/mL|
|S9433||Tubeimoside II||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9437||Echinatin||-1 mg/mL||54 mg/mL||-1 mg/mL|
|S9309||Micheliolide||-1 mg/mL||49 mg/mL||-1 mg/mL|
|S9311||Germacrone||-1 mg/mL||44 mg/mL||-1 mg/mL|
|S9313||Atractylenolide III||-1 mg/mL||50 mg/mL||-1 mg/mL|
|S9317||Forsythoside A||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9318||(20R)-Ginsenoside Rh1||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9324||Alnustone||-1 mg/mL||52 mg/mL||-1 mg/mL|
|S9350||Ethyl 4-Methoxycinnamate||-1 mg/mL||41 mg/mL||-1 mg/mL|
|S9272||Koumine||-1 mg/mL||15 mg/mL||-1 mg/mL|
|S9280||Demethoxycurcumin||-1 mg/mL||68 mg/mL||-1 mg/mL|
|S9281||Peimine||-1 mg/mL||86 mg/mL||-1 mg/mL|
|S9288||Casticin||-1 mg/mL||75 mg/mL||-1 mg/mL|
|S9287||Genkwanin||-1 mg/mL||57 mg/mL||-1 mg/mL|
|S9289||Astragalin||-1 mg/mL||90 mg/mL||-1 mg/mL|
|S9290||Linarin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9293||Isoliquiritin||-1 mg/mL||84 mg/mL||-1 mg/mL|
|S9296||Fraxin||-1 mg/mL||74 mg/mL||-1 mg/mL|
|S9297||Kirenol||-1 mg/mL||68 mg/mL||-1 mg/mL|
|S9298||Corylin||-1 mg/mL||64 mg/mL||-1 mg/mL|
|S9300||Methylprotodioscin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9304||Platycodin D||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9237||Berberrubine||-1 mg/mL||72 mg/mL||-1 mg/mL|
|S9240||Isofraxidin||-1 mg/mL||44 mg/mL||-1 mg/mL|
|S9242||Narirutin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9243||Protosappanin B||-1 mg/mL||61 mg/mL||-1 mg/mL|
|S9245||Phellodendrine chloride||-1 mg/mL||36 mg/mL||-1 mg/mL|
|S9246||Tiliroside||-1 mg/mL||3 mg/mL||-1 mg/mL|
|S9247||Isoliensinine||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9248||Homoorientin||-1 mg/mL||90 mg/mL||-1 mg/mL|
|S9254||Skimmin||-1 mg/mL||24 mg/mL||-1 mg/mL|
|S9266||Ginsenoside Rc||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9203||Notopterol||-1 mg/mL||70 mg/mL||-1 mg/mL|
|S9204||Oroxylin A||-1 mg/mL||56.9 mg/mL||-1 mg/mL|
|S9213||Jujuboside A||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9216||Esculentoside A||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9222||Dipotassium glycyrrhizinate||-1 mg/mL||25 mg/mL||-1 mg/mL|
|S9228||Schisandrin C||-1 mg/mL||76.9 mg/mL||-1 mg/mL|
|S9172||Phellodendrine||-1 mg/mL||42.6 mg/mL||-1 mg/mL|
|S9175||Macranthoidin A||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9180||Tussilagone||-1 mg/mL||78 mg/mL||-1 mg/mL|
|S9183||Ruscogenin||-1 mg/mL||86 mg/mL||-1 mg/mL|
|S9184||Forsythoside B||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9512||1,3-Dicaffeoylquinic acid||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9115||Wogonoside||-1 mg/mL||38 mg/mL||-1 mg/mL|
|s9116||Chikusetsusaponin IVa||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9120||Scutellarein||-1 mg/mL||57 mg/mL||-1 mg/mL|
|s9123||Eriodictyol||-1 mg/mL||57 mg/mL||-1 mg/mL|
|S9125||Apigetrin||-1 mg/mL||86 mg/mL||-1 mg/mL|
|s9127||Carnosol||-1 mg/mL||66 mg/mL||-1 mg/mL|
|s9128||Isoacteoside||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9129||20(S)-Ginsenoside Rh1||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9131||Punicalagin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9132||Harpagide||-1 mg/mL||72 mg/mL||-1 mg/mL|
|s9136||Neochlorogenic acid||-1 mg/mL||70 mg/mL||-1 mg/mL|
|S9144||Solasonine||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9146||Anwuligan||-1 mg/mL||65 mg/mL||-1 mg/mL|
|S9157||Neoandrographolide||-1 mg/mL||96 mg/mL||-1 mg/mL|
|S9161||Ziyuglycoside II||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9165||Poncirin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9167||Columbin||-1 mg/mL||71 mg/mL||-1 mg/mL|
|S9171||Harpagoside||-1 mg/mL||99 mg/mL||-1 mg/mL|
|s9083||Rhapontin||-1 mg/mL||84 mg/mL||-1 mg/mL|
|S9084||Rhoifolin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9085||Corynoline||-1 mg/mL||22 mg/mL||-1 mg/mL|
|S9088||Calycosin-7-O-beta-D-glucoside||-1 mg/mL||89 mg/mL||-1 mg/mL|
|S9091||10-Gingerol||-1 mg/mL||70 mg/mL||-1 mg/mL|
|S9095||Senegenin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9098||Dehydrodiisoeugenol||-1 mg/mL||65 mg/mL||-1 mg/mL|
|s9099||Orientin||-1 mg/mL||89 mg/mL||-1 mg/mL|
|s9105||Ginsenoside CK||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9112||Kaempferitrin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9113||Ononin||-1 mg/mL||86 mg/mL||-1 mg/mL|
|S9051||Asperulosid||-1 mg/mL||82 mg/mL||-1 mg/mL|
|s9052||Auraptene||-1 mg/mL||59 mg/mL||-1 mg/mL|
|S9053||Irisflorentin||-1 mg/mL||44 mg/mL||-1 mg/mL|
|s9054||Pectolinarin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S9057||Sinigrin||-1 mg/mL||79 mg/mL||-1 mg/mL|
|s9061||Hydroxy safflor yellow A||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9067||Pseudoprotodioscin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9068||Trillin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9074||Buddlejasaponin IVb||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9019||Quillaic acid||-1 mg/mL||97 mg/mL||-1 mg/mL|
|s9022||20S-Ginsenoside Rg3||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9023||20S-Ginsenoside Rh2||-1 mg/mL||100 mg/mL||-1 mg/mL|
|s9025||AtractylenolideI||-1 mg/mL||46 mg/mL||-1 mg/mL|
|S5737||Diclofenac Epolamine||82 mg/mL||82 mg/mL||82 mg/mL|
|S5674||Lodoxamide Tromethamine||19 mg/mL||<1 mg/mL||<1 mg/mL|
|S5501||Hydrocortisone acetate||-1 mg/mL||80 mg/mL||-1 mg/mL|
|S5500||Amodiaquine hydrochloride||-1 mg/mL||56 mg/mL||-1 mg/mL|
|S3969||Veratric acid||-1 mg/mL||36 mg/mL||-1 mg/mL|
|S5322||Sodium gualenate||18 mg/mL||60 mg/mL||1 mg/mL|
|S5579||Chelidonic acid||-1 mg/mL||4 mg/mL||-1 mg/mL|
|S5451||Ferulic acid methyl ester||41 mg/mL||41 mg/mL||41 mg/mL|
|S5457||Curculigoside||15 mg/mL||93 mg/mL||93 mg/mL|
|S5458||Verbascoside||100 mg/mL||100 mg/mL||23 mg/mL|
|S5459||Aucubin||15 mg/mL||69 mg/mL||<1 mg/mL|
|S5463||Curcurbitacin IIA||<1 mg/mL||100 mg/mL||5 mg/mL|
|S5471||Monotropein||78 mg/mL||78 mg/mL||<1 mg/mL|
|S5517||Fenamic acid||-1 mg/mL||42 mg/mL||-1 mg/mL|
|S3776||Sophoricoside||<1 mg/mL||86 mg/mL||<1 mg/mL|
|S5043||Benorylate||-1 mg/mL||62 mg/mL||-1 mg/mL|
|S5016||Isoprinosine||100 mg/mL||100 mg/mL||2 mg/mL|
|S5044||Isoxepac||<1 mg/mL||53 mg/mL||53 mg/mL|
|S5046||Clonixin||<1 mg/mL||52 mg/mL||15 mg/mL|
|S4966||4-Methylesculetin||-1 mg/mL||38 mg/mL||-1 mg/mL|
|S4832||Tolmetin||-1 mg/mL||51 mg/mL||-1 mg/mL|
|S4835||Aceclofenac||-1 mg/mL||70 mg/mL||-1 mg/mL|
|S3997||Oxaceprol||-1 mg/mL||34 mg/mL||-1 mg/mL|
|S4789||5-Acetylsalicylic acid||-1 mg/mL||36 mg/mL||-1 mg/mL|
|S5157||Thymol||-1 mg/mL||30 mg/mL||-1 mg/mL|
|S3982||Batyl alcohol||-1 mg/mL||68 mg/mL||-1 mg/mL|
|S3906||Astragalus polyphenols||-1 mg/mL||81 mg/mL||-1 mg/mL|
|S3877||Lysionotin||-1 mg/mL||68 mg/mL||-1 mg/mL|
|S3881||Scopoletin||-1 mg/mL||38 mg/mL||-1 mg/mL|
|S3790||Methyl gallate||-1 mg/mL||36 mg/mL||-1 mg/mL|
|S3799||Gentisic acid||-1 mg/mL||30 mg/mL||-1 mg/mL|
|S3765||Picroside II||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S1439||Tranilast||<1 mg/mL||66 mg/mL||<1 mg/mL|
|S4169||Teriflunomide||<1 mg/mL||32 mg/mL||,1 mg/mL|
|S2413||Geniposidic acid||<1 mg/mL||16 mg/mL||2 mg/mL|
|S1939||Levamisole hydrochloride||48 mg/mL||<1 mg/mL||<1 mg/mL|
|S1681||Mesalamine||<1 mg/mL||31 mg/mL||31 mg/mL|
|S2910||Tempol||34 mg/mL||34 mg/mL||34 mg/mL|
|S1679||Flurbiprofen||<1 mg/mL||49 mg/mL||49 mg/mL|
|S3062||Diclofenac Potassium||10 mg/mL||69 mg/mL||<1 mg/mL|
|S4098||Halcinonide||<1 mg/mL||90 mg/mL||4 mg/mL|
|S1823||Fenoprofen Calcium||<1 mg/mL||105 mg/mL||10 mg/mL|
|S3614||Lupeol||<1 mg/mL||1 mg/mL||<1 mg/mL|
|S3956||Tetramethylpyrazine||-1 mg/mL||27 mg/mL||-1 mg/mL|
|S3824||Quercitrin||-1 mg/mL||89 mg/mL||-1 mg/mL|
|S3837||Echinocystic acid||-1 mg/mL||94 mg/mL||-1 mg/mL|
|S3841||Eleutheroside B||-1 mg/mL||74 mg/mL||-1 mg/mL|
|S4152||Ethamsylate||53 mg/mL||53 mg/mL||<1 mg/mL|
|S2383||Gastrodin||<1 mg/mL||50 mg/mL||<1 mg/mL|
|S2387||Lappaconite HBr||<1 mg/mL||28 mg/mL||<1 mg/mL|
|S4165||Benzydamine HCl||69 mg/mL||69 mg/mL||69 mg/mL|
|S4170||Coumarin||<1 mg/mL||29 mg/mL||29 mg/mL|
|S2400||Rheic Acid||<1 mg/mL||<1 mg/mL||<1 mg/mL|
|S4188||Sasapyrine||<1 mg/mL||52 mg/mL||52 mg/mL|
|S7448||CORM-3||<1 mg/mL||38 mg/mL||<1 mg/mL|
|S3932||Astilbin||-1 mg/mL||100 mg/mL||-1 mg/mL|
|S4682||Loxoprofen||<1 mg/mL||49 mg/mL||49 mg/mL|
|S3774||Dehydroandrographolide Succinate Potasium Salt||-1 mg/mL||10 mg/mL||-1 mg/mL|
|S3775||Ligustrazine hydrochloride||-1 mg/mL||34 mg/mL||-1 mg/mL|
|S8141||Cl-amidine||70 mg/mL||84 mg/mL||84 mg/mL|
|S3027||Fenoprofen calcium hydrate||<1 mg/mL||48 mg/mL||18 mg/mL|
|S8097||C-DIM12||<1 mg/mL||71 mg/mL||71 mg/mL|
|S2350||Rutin||<1 mg/mL||100 mg/mL||2 mg/mL|
|S3106||Pidotimod||10 mg/mL||49 mg/mL||<1 mg/mL|
|S4515||Ademetionine disulfate tosylate||79 mg/mL||79 mg/mL||<1 mg/mL|
|S3745||Balsalazide disodium||87 mg/mL||87 mg/mL||<1 mg/mL|
|S4690||Escin||<1 mg/mL||66 mg/mL||<1 mg/mL|
|S3685||4-Biphenylacetic acid||<1 mg/mL||42 mg/mL||42 mg/mL|
- Immunology & Inflammation related Inhibitors (256)
- New Immunology & Inflammation related Products
|Catalog No.||Information||Product Use Citations||Product Validations|
Rituximab (anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.
Ipilimumab (anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.
Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.
Repression of BSEP gene expression upon treatment with reported BSEP inhibitors in human primary hepatocytes. BSEP mRNA expression was measured using real-time PCR in hepatocytes from at least three donors upon treatment with BSEP inhibitors as described under Materials and Methods. All the data are expressed as mean ?S.D. (n = 3).
Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.
Pim inhibits nuclear factor of activated T-cell (NFAT) translocation of cultured human vascular smooth muscle cells. hCASM expressing green fluorescent protein-NFAT were incubated with 10 uM Pim for 30 min. Left: mean nuclear/cytosol fluorescence intensity ratio (±SE) is displayed at basal conditions and after stimulation with 500 uM ATP in the absence and presence of Pim.
Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
Differential participation of ATRs or MCP-1/CCR2 signaling in RVLM in pressor response and tachycardia after stroke. Changes in mean diastolic (ΔDBP) blood pressure or heart rate (ΔHR) relative to baseline in rats that received pretreatment by microinjection bilaterally into the RVLM of bindarit (Bin; 10 nmol, MCP-1 synthesis inhibitor), BMS CCR2 22 (BMS; 10 pmol, CCR2 antagonist), propagermanium (Prop; 10 pmol, CCR2 antagonist) or vehicle control (Veh).Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus SC group, and +P < 0.05 versus Veh (Saline) + MCAO group in the post hoc Scheffe multiple-range test.
Bestatin is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.
The aminopeptidase-N inhibitor, bestatin (C), showed an inhibitory effect on cell proliferation that predominated in mixed-IHCCA. *p< 0.05 mucin vs mixed, N experiments = 5-7.
CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself。 It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively.
Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation.
Sanguinarine, a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.
Chicago Sky Blue 6B is a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. It is an inhibitor of macrophage migration inhibitory factor (MIF) with an IC50 of 0.81 μM.
Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.
Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.
Peiminine, a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.
Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α.
Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.
Salvianolic acid A, a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.
Trilobatin, a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.
Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
GI254023X is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 amd ADAM17 are 5.3 nM and 541 nM, respectively.
Tiaprofenic acid is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.
Loxoprofen sodium is a non-steroidal anti-inflammatory drug.
Bendazac is a non-steroidal anti-inflammatory drug that delays the cataractogenic process. It may act by preventing protein denaturation.
Diflorasone acts as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties.
Saikosaponin A is a triterpene saponin derived from the medicinal plant, Bupleurum chinensis DC. (Umbelliferae). It has a variety of pharmacological benefits, including anti-inﬂammatory, immunomodulatory, and anti-bacterial activities.
ISO-1 is an inhibitor of MIF (Macrophage migration inhibitory factor) D-dopachrome tautomerase activity with an IC50 of ~7 μM.
Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis.
Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.
Demethylzeylasteral (T-96), the active component isolated from Tripterygium wilfordii Hook F., inhibits UDP-glucuronosyltransferase (UGT) isoforms UGT1A6 and UGT2B7 with immunosuppressive effects.
Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.
Royal jelly acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.
INF39 is a nontoxic, irreversible NLRP3 inhibitor that counteracts NLRP3 activation through direct irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.
MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
A-C, Expression of caspase 1 and its active form caspase 1-p20, as demonstrated in representative Western blots (top) and the relative expression levels (B and C) in each group.
Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.
Atractylenolide I is the major sesquiterpenoid of the rhizome of A. macrocephala and shows a wide spectrum of pharmacological activities such as antiinflammatory, digestion promoting, and antioxidant effects.
Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.
Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities.
TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.
(B) Florescent images of EpEX (green) and EpICD (red) in PK-15 cells, which were transfected by pSIN-fEpCAM-mCherry and treated with or without TAPI-1/DAPT. Nuclei were stained by Hoechst 33342 (blue). Scale bar, 25 μm.
NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
Xanthotoxol, a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.
Setipiprant(ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1.
Pranlukast is an orally administered, and selective antagonist of the cysteinyl leukotrienes (LT) C(4), LTD(4) and LTE(4), used in the prophylactic treatment of chronic bronchial asthma.
PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.
MRE-269(ACT-333679) is a prostaglandin I2 (IP) receptor agonist with a binding affinity for the human IP receptor that is 130-fold greater than that for other human prostanoid receptor.
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.
Idramantone is an immune agonist.
Selexipag is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).
Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities.
Actarit is an orally active immunomodulator used in the treatment of rheumatoid arthritis.
Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from
Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation.
Motor disturbances of the rat hindlimbs after SCI, using an inclined plane test. Key: ◇ = PBS group; ■ = Sal B group; ▲ = methylprednisolone group.
Laquinimod is a potent immunomodulator. Phase 3.
VGX-1027 is an orally active immunomodulator. Phase 1.
AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.
Thymopentin has immuno-regulatory activities. The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.
Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
Imiquimod is a novel synthetic agent with immune response modifying activity.
p-Coumaric acid ethyl ester is the ethyl ester of p-Coumaric acid, which is a plant metabolite which exhibits antioxidant and anti-inflammatory properties.
N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.
Fosfosal (2-phosphonoxy benzoic acid) is a non-acetylated salicylic acid derivative, with analgesic and anti-inflammatory activity, but without effects on PG biosynthesis in vitro.
6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.
Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects.
Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects.
Isovitexin, an active component of many traditional Chinese medicines, has various activities, such as anti-oxidant, anti-inflammatory, anti-alzheimer disease (AD) effects and so on.
(20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor.
Tenacissoside H, a natural compound found in M. tenacissima, exerts anti-inflammatory and anti-tumor effects.
Calycosin, an isoflavonoid, is the major active component in Radix Astragali. It shows antitumor, anti-inflammatory, neuroprotective and pro-angiogenesis effects.
Stearyl glycyrrhetinate, the stearyl ester of 18-β-glycyrrhetinic acid, has been demonstrated to improve antiviral effects, reduce inflammation and suppress allergies in the pharmaceutical and cosmetic industry.
Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial.
Stylopine, a major component of the leaf of Chelidonium majus L., is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
Decursin (D), purified from Angelica gigas Nakai, shows potential anti-inflammatory activity and neuroprotective property.
Kaurenoic acid is a natural diterpenoid found in the herbs of Croton antisyphiliticus. Kaurenoic acid has anti-inflammatory activity, the mechanisms may through inhibition of iNOS and COX-2 expression.
Naringenin chalcone is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism.
Madecassic acid, a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and altering lipid metabolism in mice, at least in part through antioxidant actions.
Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities.
Sesamoside, a main chemical ingredient iridoid glycoside from Lamiophlomic rotata, has analgesic and anti-inflammatory effects in animal studies.
Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, possesses diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects.
Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc.
Beta-Elemonic acid, a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.
Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.
Homoplantaginin, a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties.
Trifolirhizin, a natural pterocarcan flavonoid extracted from Sophora flavescens, has many pharmacological activities, such as hepatoprotective, anti-inflammatory, anti-proliferation, and skin-whitening.
Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus and shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity.
Tomatidine, a natural steroidal alkaloid, possesses potent antibacterial activity and has anti-inflammatory effects in macrophages.
Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system.
Tubeimoside II, a natural triterpenoid saponin isolated from herb, show anti-inflammatory, antitumor, and antitumor-promoting effects.
Echinatin is a licorice extract that displays antioxidant properties and anti-inflammatory activities.
Micheliolide, a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, inhibits various inflammatory response and may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders.
Germacrone, a major activity component found in Curcuma zedoaria oil product, shows anti-inflammatory, antiandrogenic, and antimicrobial activities.
Atractylenolide III, a major component of Atractylodes rhizome, has anti-inflammatory and anti-angiogenesis activities.
Forsythoside A, one of the main active ingredients in Forsythiae fructus, has been shown to possess anti-bacterial and immunomodulatory properties.
(20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer.
Alnustone, a naturally occuring compound found in the rhizomes of Curcuma xanthorrhiza, exhibits anti-inflammatory, antihepatotoxic and antiemetic activities.
Ethyl 4-Methoxycinnamate, a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.
Koumine, a Gelsemium alkaloid, possesses analgesic, anti-inflammatory and neurosteroid modulating activities.
Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.
Peimine is a major biologically active component of Fritillaria ussuriensis, exhibits anti-inflammatory and pain suppression properties at the cellular level.
Casticin, as the major active substance in Lithospermum erythrorhyzon, had been reported to mediate multiple pharmacological activities such as antioxidation, antiviral, cardiovascular protection, antineoplastic and anti-inflammation.
Genkwanin is one of the major non-glycosylated flavonoids in herbs. It has a variety of pharmacological effects including anti-inflammatory, anti-bacterial, antiplasmodial, radical scavenging, chemopreventive and inhibiting 17β-Hydroxysteroid dehydrogenase type 1 activities.
Astragalin, a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities.
Linarin, a natural flavonoid cpompound, has pharmacological effects, including anti-inflammatory, neuro-protective, cardioprotective and antioxidative effects.
Isoliquiritin is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities.
Fraxin, a main active component isolated from Cortex Fraxini, possesses a variety of bioactivities such as anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory, anti-hyperuricemia and diuresis.
Kirenol is a biologically active substance isolated from Herba Siegesbeckiae. It has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities.
Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties.
"Methyl protodioscin, a bioactive natural compound isolated from Dioscorea collettii Makino (Dioscoreaceae), has numerous pharmacological activities, including anti-inflammation, lipid-lowering, and anticancer activities."
Platycodin D, the main saponin isolated from Chinese herb Platycodonis Radix, exhibits anti-inflammatory, anti-allergic, cholesterol-lowering and neuroprotective properties.
Berberrubine, an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects.
Isofraxidin, a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
Narirutin, a flavanone abundant in citrus fruits, possesses anti-inflammatory and anti-oxidative effects.
Protosappanin B, extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.
Phellodendrine chloride, isolated from the Phellodrndron amurensis, exhibits immunosuppressive and anti-inflammatory activities.
Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities.
Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera. It possesses anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.
Homoorientin is a flavone that acts as a radical scavenger and an antineoplastic agent.
Skimmin is one of the major pharmacologically active molecules present in Hydrangea paniculata, a medical herb used in the traditional Chinese medicine as an anti-inflammatory agent.
Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects.
Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities.
Oroxylin A is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties.
Jujuboside A, isolated from Semen Ziziphi Spinosae, exerts anti-oxidant, anti-inflammatory activities, and reduces the cell apoptosis.
Esculentoside A, isolated from the Chinese herb phytolacca esculenta, possesses a broad inhibitory effect on a panel of pro-inflammation molecules with less toxicity.
Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation.
Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis.
Macranthoidin A, found in the herbs of Lonicera japonica Thunb., has anti-inflammation activity.
Tussilagone, isolated from the flower of buds of Tussilago farfara (Compositae), is a sesquiterpenoid that is used as a traditional oriental medicine for asthma and bronchitis. It shows anti-inflammatory activity in in vitro studies.
Ruscogenin, a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been reported to exert significant anti-inflammatory and anti-thrombotic activities.
Forsythoside B has potent neuroprotective effects and has anti-inflammation, antioxidant, and antisepsis properties.
1,3-Dicaffeoylquinic acid is a phenolic compound found in artichoke. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
Wogonoside, the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities.
Chikusetsusaponin IVa, a major active ingredient of triterpenoid saponins, has numerous pharmacological activities, including cytotoxic activity against various cancer cells, anti-inflammatory activity, prevention of dental caries and induction of genta-micin nephrotoxicity.
Scutellarein, extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities
Eriodictyol, a flavonoid extracted from yerba santa, has anti-inflammatory and antioxidant activities and taste-modifying properties.
Apigetrin, a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.
Carnosol is a naturally occurring phenolic diterpene found in rosemary. It has anti-oxidant, anti-inflammatory and anti-cancer activities.
Isoacteoside, a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., is an anti‐inflammatory herb widely used in traditional Chinese medicine.
20(S)-Ginsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. It exhibits potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system.
Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.
Harpagide, isolated from the secondary roots of Harpagophytum procumbens (Hp), has valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects.
Neochlorogenic acid is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
Solasonine, a natural glycoalkaloid compound, has anti-inflammation and anti-tumor properties.
Anwuligan, a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities.
Neoandrographolide, a principle diterpenoids isolated from A. paniculata, exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.
Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties.
Poncirin, extracted from trifoliate orange, has anti-bacterial and anti-inflammatory activities.
Columbin, a diterpenoid furanolactone, is a potential anti-inflammatory drug.
Harpagoside, a natural product found in the plant Harpagophytum procumbens, has potent anti-rheumatic, anti-inflammatory and analgesic effects.
Rhapontin, a stibene-type glycoside distributed widely in medicinal plants of Rheum genus (Polygonaceae), has anti-inflammatory effect and anti-proliferative activity.
Rhoifolin, a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.
Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc.
Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities.
10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity.
Senegenin is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.
Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition.
Orientin, isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
Ginsenoside CK is a ginsenoside found in Panax species and has a role as a plant metabolite, an antineoplastic agent, a hepatoprotective agent, an anti-allergic agent and an anti-inflammatory agent.
Kaempferitrin, isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
Ononin is an isoflavone glycoside with anti-inflammtory effects.
Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect.
Auraptene is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects.
Irisflorentin derived from the roots of Belamcanda chinensis (L.) DC. is an herb which has been used for the treatment of inflammatory disorders in traditional Chinese medicine.
Pectolinarin is a major compound in Cirsium setidens with anti-inflammatory activity.
Sinigrin is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects. Sinigrin is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.
Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects.
Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities.
Trillin is an active ingredient isolated from Dioscorea nipponica Makino and acts as a potential anti-inflammatory drug for chronic hepatic inflammation.
Buddlejasaponin Ivb, a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells.
20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities.
20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis.
Atractylenolide I (ATL-I) is a bioactive component of Rhizoma Atractylodis macrocephalae and shows anti-inflammatory effects.
Diclofenac Epolamine is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.
Lodoxamide Tromethamine is the tromethamide salt form of lodoxamide, a synthetic mast cell stabilizing compound with anti-inflammatory activity.
Iguratimod is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis.
Hydrocortisone Acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
Veratric acid, a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects.
Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound, which is gradually decomposed in the solid state at room temperature. It has anti-inflammatory and wound-healing effects.
Chelidonic acid is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals.
Methyl ferulate is a lipophilic derivative of ferulic acid, which is a hydroxycinnamic acid that is abundant in plants. It shows the strongest antioxidant activity and can protect against inflammation and cancer.
Curculigoside, a diterpenoid triepoxide, is one of the main bioactive phenolic compounds isolated from the rhizome of Curculigo orchioides Gaertn. and has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects.
Verbascoside, a phenylpropanoid glycoside from lemon verbena, has several biological properties such as anti-inflammatory, antimicrobial, antitumor, and antioxidant.
Aucubin, an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.
Cucurbitacin IIa (CuIIa) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects.
Monotropein, an iridoids glycoside isolated from the roots of Morinda officinalis How, has been demonstrated to exhibit anti-inflammatory activity.
Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.
Ufenamate is an anthranilic acid derivative with anti-inflammatory activity.
Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
Sophoricoside (SOPH) is an isoflavone isolated from Sophora japonica (Leguminosae) with numerous pharmacological effects, including anti- inflammatory, anti-cancer and immunosuppressive effects.
Benorylate is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
Isoprinosine is an immunopharmacologic agent with antiviral activities.
Isoxepac is a non-steroidal arylacetic acid derivative with anti-inflammatory, analgesic and antipyretic activity.
Clonixin is a nonsteroidal anti-inflammatory drug with analgesic, antipyretic, and platelet-inhibitory actions.
4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.
Tolmetin is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.
Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.
5-Acetylsalicylic acid is a nonsteroidal anti-inflammatory drug.
Thymol, a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.
Batyl alcohol, isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent.
Astragalus is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body. It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions.
Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.
Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.
Bakuchiol is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
Methyl Gallate is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.
Gentisic acid, an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.
Picroside II is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
Cells were cultured in LD collagen gels ± vehicle control (V), 100 M DFOM (D) or tranilast (T) for 24h (E-H) and assessed for P450 enzyme production.
Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.
Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.
Levamisole, also known as (-)-Tetramisole, is an inhibitor of alkaline phosphatase, used as an anthelmintic.
Mesalamine is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.
Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).
Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
Lupeol is a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms with anticancer, antiprotozoal, chemopreventive and anti-inflammatory properties.
Tetramethylpyrazine (ligustrazine, TMP) is a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
Quercitrin (3-rhamnosyl quercetin), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.
Echinocystic acid (EA), a natural triterpone enriched in various herbs, displays a range of pharmacological activities including anti-inflammatory and antioxidant effects.
Eleutheroside B (syringin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.
Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion.
Gastrodin, an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects.
Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity.
Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.
Eucalyptol is a natural organic compound which controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.
Rhein (Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities.
Sasapyrine (salsalate) is a nonsteroidal oral anti-inflammatory agent.
CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
Astilbin, a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
Bornyl acetate, the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.
Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
Tetramethylpyrazine, also known as ligustrazine, is a chemical compound found in natto and in fermented cocoa beans with anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively.
Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).
Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent.
Eugenol is a naturally occuring scent chemical found in clove oil and other plants. The physiologic effect of eugenol is by means of increased Histamine Release, and cell-mediated Immunity.
C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
Rutin, a flavonol glycoside found in many plants including buckwheat; tobacco; forsythia; hydrangea; viola, etc., which possesses healthy effects for human.
Pidotimod is an immunostimulant.
Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.
Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine.
Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).
4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.
2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.