Immunology & Inflammation related Inhibitors/Modulators

Other Immunology & Inflammation Related Inhibitors

CXCR AhR STING COX IL Receptor gp120/CD4 NOD NADPH-oxidase ROS Nrf2

Cat.No.	Product Name	Information	Product Use Citations
S8141	Cl-amidine	Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. Cl-amidine induces apoptosis.	Immunity, 2025, S1074-7613(25)00069-X Cell Rep, 2025, 44(2):115226 Nat Commun, 2024, 15(1):8663
S1591	Bestatin (Ubenimex)	Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.	PLoS One, November 16, 2015, e0142124 Aging (Albany NY), April 11, 2022, 3259-3275 Cell Reports, 2024, 114041
S2286	Cyclosporin A	Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.	Frontiers in Immunology, May 25, 2022, 861292 Circulation Research, March 27, 2026, e327680 Anticancer Research, March 2023, 1103-1112
S8760	Iberdomide (CC-220)	Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.	Cell Rep Med, 2025, S2666-3791(25)00102-8 J Med Virol, 2025, 97(8):e70537 Cancer Res, 2025, 10.1158/0008-5472.CAN-24-1136
S3032	Bindarit (AF 2838)	Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.	International Journal of Biological Sciences, 2025, 21(14):6113-6131 Exp Mol Med, 2024, 56(2):408-421. PLoS Pathog, 2024, 20(11):e1012747
S1576	Sulfasalazine	Sulfasalazine is a sulfa derivative of mesalazine, used as an anti-inflammatory agent to treat bowel disease and rheumatoid arthritis. This compound is a potent and specific inhibitor of nuclear factor kappa B (NF-κB), TGF-β and COX-2. It induces ferroptosis, apoptosis and autophagy.	Science Advances, August 27, 2021, eabj0364 Oncology Letters, April 1, 2026, 31 Med Oncol, 2024, 41(8):188
S1439	Tranilast	Tranilast is an antiallergic drug by inhibiting lipid mediator and cytokine release from inflammatory cells, used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.	EMBO Mol Med, 2025, 17(4):747-774 Virol J, 2025, 22(1):301 PLoS One, 2025, 20(2):e0319381
S2910	Tempol	Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.	Autophagy, 2025, 1791-1801 Cell Death Dis, 2024, 15(10):760 Cell Signal, 2023, 108:110712
S3648	Amlexanox	Amlexanox is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.	Biomed Pharmacother, 2025, 186:117991 Cell Death Discov, 2025, 11(1):286 Sci Adv, 2025, 11(4):eadq2395
S5004	Pimecrolimus	Pimecrolimus (Elidel,ASM 981,SDZ-ASM 981) is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12 (FKBP-12); a calcineurin inhibitor.	PLoS Pathogens, November 20, 2020, e1009022 International Journal of Pharmaceutics, April 5, 2022, 121610 iScience, 2024, 27(10):110862
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