Levamisole hydrochloride

For research use only.

Catalog No.S1939 Synonyms: (-)-Tetramisole hydrochloride

Levamisole hydrochloride Chemical Structure

CAS No. 16595-80-5

Levamisole, also known as (-)-Tetramisole, is an inhibitor of alkaline phosphatase, used as an anthelmintic.

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Biological Activity

Description Levamisole, also known as (-)-Tetramisole, is an inhibitor of alkaline phosphatase, used as an anthelmintic.
In vitro

L-tetramisole (250 and 500 mg/mL) suppresses IFN synthesis in the cells from BALB/c and NZB mice. L-tetramisole (125 mg/mL) inhibits the IFN production only partially and this effect is observed when the IFN production is high. L-tetramisole affects the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells. [1]

In vivo Tetramisole leads to the mean faecal egg count rose from 3 weeks after treatment and remain continuously higher than those Closantel or Albendazole treated group up to 12 weeks after treatment. [2] Tetramisole reduces neuronal response amplitude in a dose-dependent manner in mouse cortex. Tetramisole also decreases axonal conduction velocity in mouse cortex. [3] Tetramisole significantly increases the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Tetramisole significantly increases stereotyped behavior of the mice on days 3, 5 and 8 in comparison with respective control values. Tetramisole treatments (0.5 and 1mg/kg) also significantly decreases the time needed to complete the negative geotaxis task and reduces landing foot splay. [4]


Solubility (25°C)

In vitro Water 48 mg/mL (199.37 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 240.75


CAS No. 16595-80-5
Storage powder
in solvent
Synonyms (-)-Tetramisole hydrochloride
Smiles C1CSC2=NC(CN21)C3=CC=CC=C3.Cl

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID