Diclofenac Potassium

Catalog No.S3062 Synonyms: CGP-45840B

For research use only.

Diclofenac potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Potassium Chemical Structure

CAS No. 15307-81-0

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Biological Activity

Description Diclofenac potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
In vitro

The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 334.24


CAS No. 15307-81-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[K+]

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03150732 Not yet recruiting Drug: Systemic nalbuphine|Drug: Local nalbuphine Postoperative Pain Assiut University April 10 2022 Not Applicable
NCT05267379 Not yet recruiting Diagnostic Test: Take blood samples Post-ERCP Acute Pancreatitis Radboud University Medical Center March 1 2022 --
NCT05171673 Recruiting Drug: Licart™ (diclofenac epolamine) topical system Soft Tissue Injuries IBSA Institut Biochimique SA October 31 2021 Phase 3
NCT05026320 Completed Drug: Naproxen gel|Drug: Diclofenac gel|Drug: Placebo gel Soft Tissue Injury Bayer|Deutsche Sporthochschule Köln August 8 2021 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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