Diclofenac Potassium

For research use only.

Catalog No.S3062 Synonyms: CGP-45840B

Diclofenac Potassium Chemical Structure

Molecular Weight(MW): 334.24

Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Biological Activity

Description Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
In vitro

The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Protocol

Solubility (25°C)

In vitro DMSO 69 mg/mL (206.43 mM)
Water 10 mg/mL (29.91 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 334.24
Formula

C14H10Cl2KNO2

CAS No. 15307-81-0
Storage powder
in solvent
Synonyms CGP-45840B
Smiles [K+].[O-]C(=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04341402 Recruiting Drug: Antifungal Nail Gel Study Tinea Unguium Onychomycosis William N Handelman|Bay Area Medical May 1 2020 Phase 2
NCT04111081 Enrolling by invitation Other: Auricular pressure|Other: Shame auricular pressure Postoperative Pain Chengdu University of Traditional Chinese Medicine March 1 2020 Not Applicable
NCT04132583 Completed Drug: Deflox®|Drug: Cataflam DD® Healthy Merck Healthcare KGaA Darmstadt Germany an affiliate of Merck KGaA Darmstadt Germany October 18 2019 Phase 1
NCT03497039 Completed Drug: Diclofenac Diethylamine (DDEA) gel|Other: Placebo gel Pain GlaxoSmithKline July 19 2018 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID