Diclofenac Potassium

Catalog No.S3062 Synonyms: CGP-45840B

Diclofenac Potassium Chemical Structure

Molecular Weight(MW): 334.24

Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
In vitro

The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.


Solubility (25°C)

In vitro DMSO 69 mg/mL (206.43 mM)
Water 10 mg/mL (29.91 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 334.24


CAS No. 15307-81-0
Storage powder
in solvent
Synonyms CGP-45840B

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03595150 Not yet recruiting Common Bile Duct Diseases Karolinska Institutet|Uppsala University January 1 2019 Phase 2|Phase 3
NCT03471507 Not yet recruiting Chronic Pain|Musculoskeletal Pain Winston Parris MD|Duke University December 1 2018 Phase 1
NCT02985671 Not yet recruiting Postural Low Back Pain|Mechanical Low Back Pain Ache Laboratorios Farmaceuticos S.A. December 1 2018 Phase 3
NCT03605914 Recruiting Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty The University of Texas Health Science Center Houston August 1 2018 Phase 4
NCT03497039 Recruiting Pain GlaxoSmithKline July 19 2018 Phase 1
NCT03528824 Recruiting Osteoarthritis Knee Universität Duisburg-Essen June 1 2018 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID