Catalog No.S4709 Synonyms: Xalatan, PhXA41, PHXA-41

Latanoprost Chemical Structure

Molecular Weight(MW): 432.59

Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.

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Description Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
retinoid X receptor α [2]
PGF-prostanoid receptor [3]
In vitro

Latanoprost functioned as both an indirect activator of AMP-activated protein kinase and a selective retinoid X receptor α (RXRα) antagonist able to selectively antagonise the transcription of a RXRα/peroxisome proliferator-activated receptor γ heterodimer[2]. Latanoprost induced morphological abnormality and viability decline of HCS cells in vitro. It induces cell cycle arrest of HCS cells. Latanoprost induces abnormal changes of plasma membrane, DNA fragmentation and ultrastructural abnormality of HCS cells. Caspase activation in HCS cells is also activated by Latanoprost treatment. Latanoprost induces MTP disruption and quantitative changes of mitochondrion-associated pro-apoptotic regulators in HCS cells[1]. Latanoprost is effective in inhibiting adipogenesis, reducing lipogenesis, promoting fatty acid oxidation and enhancing GLUT4 translocation and glucose uptake both in adipocytes and myotubes[2].

In vivo Latanoprost, a clinical drug for treating primary open-angle glaucoma and intraocular hypertension, effectively ameliorates glucose and lipid disorders in two mouse models of type 2 diabetes. Its treatment improves glucose tolerance. Chronic administration of latanoprost decreases serum lipids and enhances insulin signalling in white adipose tissue and skeletal muscle. It effectually activates AMPK and regulates glucose and lipid metabolism-relevant genes in diabetic mice[2].


Cell Research:[1]
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  • Cell lines: Human corneal stromal (HCS) cells
  • Concentrations: from 50 mg/l to 0.78125 mg/l
  • Incubation Time: 4, 8, 12 h
  • Method: HCS cells were inoculated into a 24-well culture plate (Nunc) and cultured in 10% FBS-DMEM/F12 medium at 37°C in a humidified 5% CO2 incubator. After the cells grew into logarithmic phase, the culture medium of each culture plate well was replaced entirely with the medium containing latanoprost at concentrations varying from 50 mg/l to 0.78125 mg/l, respectively. The cells were cultured under the same condition as described earlier, and their morphology and growth status were monitored every 4 h under an Eclipse TS100 inverted microscope.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: db/db or ob/ob mice
  • Formulation: 0.5% Tween 80
  • Dosages: 10 or 40 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 432.59


CAS No. 130209-82-4
Storage powder
in solvent
Synonyms Xalatan, PhXA41, PHXA-41

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03648229 Not yet recruiting Open-angle Glaucoma West Virginia University|University of Pittsburgh|University of Michigan September 1 2019 Phase 4
NCT03611348 Not yet recruiting Vitiligo Sohag University September 1 2018 Phase 2|Phase 3
NCT03657797 Recruiting Glaucoma Open-Angle|Hypertension Ocular Nicox Ophthalmics Inc. August 1 2018 Phase 2
NCT03318146 Not yet recruiting Glaucoma|Ocular Hypertension|IOP Shaare Zedek Medical Center June 1 2018 Not Applicable
NCT03480906 Completed Intraocular Pressure Eyenovia Inc. March 12 2018 Not Applicable
NCT03274323 Withdrawn Glaucoma Open-Angle Johns Hopkins University January 12 2018 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID