For research use only.

Catalog No.S2787 Synonyms: ABR-215062, LAQ

2 publications

Laquinimod Chemical Structure

CAS No. 248281-84-7

Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3.

Selleck's Laquinimod has been cited by 2 publications

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Biological Activity

Description Laquinimod (ABR-215062, LAQ) is a potent immunomodulator. Phase 3.
In vitro

Laquinimod treatment at 0.1-1 μM does not affect the viability of peripheral blood mononuclear cells (PBMC). By performing the large-scale gene expression microarray analysis in PBMC from healthy subjects or relapsing-remitting multiple sclerosis (RRMS) patients, Laquinimod is shown to induce suppression of genes related to antigen presentation and corresponding inflammatory pathways. Laquinimod induces activation of Th2 response in CD14+ and CD4+ cells and suppression of proliferation in CD8+ cells. Laquinimod displays significant effects on immune modulation related to the suppression of antigen presenting mechanism followed by a decrease of chemotaxis and adhesion, and exhibits potent anti-inflammatory potency through the suppression of the NF-κB pathway that concordantly leads to the activation of apoptosis of immuno-competent cells. [5]

In vivo Administration of Laquinimod (0.16-16 mg/kg/day) dose-dependently inhibits the incidence of experimental autoimmune neuritis (EAN) in Lewis rats, ameliorates clinical signs and inhibits P0 peptide 180-199-specific T cell responses as well as the inflammation and demyelination in the peripheral nerves, suggesting that Laquinimod may mediate its effects by regulation of Th1/Th2 cytokine balance. [1] Laquinimod significantly inhibits the development of murine acute experimental autoimmune encephalomyelitis (EAE), being approximately 20 times more potent than the immunomodulator roquinimex. [2] Laquinimod treatment inhibits the development of experimental autoimmune encephalomyelitis (EAE) in the Lewis rat in a dose-dependent manner, and shows better disease inhibitory effects as compared to roquinimex (Linomide). [3] Laquinimod potently inhibits the development of chronic experimental autoimmune encephalomyelitis (chEAE) in IFN-beta k.o. mice and wild type mice. [4] Laquinimod reduces clinical signs, inflammation, and demyelination in C57BL/6 mice with active EAE induced with MOG(35-55) peptide, and down-regulates VLA-4-mediated adhesiveness and pro-inflammatory cytokines such as IL-17. [6] The study of Laquinimod in the mice model of EAE using a conditional BDNF knockout strain lacking BDNF expression in myeloid cells and T cells (LLF mice) indicates Laquinimod also modulates autoimmune demyelination via induction of brain-derived neurotrophic factor (BDNF). [7]


Cell Research:[5]
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  • Cell lines: PBMC
  • Concentrations: Dissolved in PBS, final concentrations ~1 μM
  • Incubation Time: 24 hours
  • Method: The peripheral blood mononuclear cells (PBMC) are incubated with Laquinimod for 24 hours. Cell viability is measured on total PBMC by propidium iodide (PI) staining using an automated cell counter. Protein expression level is assessed in PBMC samples by Western blot using anti-HLA-DQA/DQB monoclonal antibodies.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Lewis rats with experimental autoimmune neuritis (EAN) induced by inoculation with peripheral nerve myelin P0 protein peptide 180-199 and Freund's complete adjuvant
  • Dosages: 0.16, 1.6 and 16 mg/kg/day
  • Administration: Administered via a daily subcutaneous injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 61 mg/mL (170.96 mM)
Ethanol 1 mg/mL (2.8 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 356.8


CAS No. 248281-84-7
Storage powder
in solvent
Synonyms ABR-215062, LAQ
Smiles CCN(C1=CC=CC=C1)C(=O)C2=C(C3=C(C=CC=C3Cl)N(C2=O)C)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02772523 Completed Other: Lifestyle recommendations Alzheimer''s Disease Barcelonabeta Brain Research Center Pasqual Maragall Foundation May 2016 Not Applicable
NCT02085863 Completed Drug: laquinimod|Drug: Placebo Pharmacokinetics|Pharmacodynamics Teva Pharmaceutical Industries February 2014 Phase 1
NCT01975298 Withdrawn Drug: Laquinimod|Drug: Avonex® Relapsing Remitting Multiple Sclerosis Teva Pharmaceutical Industries January 2014 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID