Imiquimod (R-837)

Catalog No.S1211 Synonyms: S-26308

For research use only.

Imiquimod (R-837, S-26308) is a novel synthetic agent with immune response modifying activity.

Imiquimod (R-837) Chemical Structure

CAS No. 99011-02-6

Selleck's Imiquimod (R-837) has been cited by 3 Publications

Purity & Quality Control

Choose Selective Immunology & Inflammation related Inhibitors

Biological Activity

Description Imiquimod (R-837, S-26308) is a novel synthetic agent with immune response modifying activity.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 1 mg/mL warmed
(4.16 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 240.3


CAS No. 99011-02-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04883645 Recruiting Drug: Imiquimod 5% CreamTopPkt0.25Gm Oral Cancer Columbia University September 2021 Early Phase 1
NCT04642937 Active not recruiting Drug: Treatment with hP1A8 Glioblastoma OX2 Therapeutics December 1 2020 Phase 1
NCT02301494 Withdrawn Drug: 3.75% Imiquimod Cream|Drug: 0.1% Fluocinonide Cream Mycosis Fungoides Rochester General Hospital|Bausch Health Americas Inc.|Rochester Skin Lymphoma Medical Group PLLC April 2020 Not Applicable
NCT03196180 Active not recruiting Drug: Imiquimod|Drug: Topical Fluorouracil Cervical Intraepithelial Neoplasia Grade 2/3|Cervical Squamous Cell Carcinoma In Situ|Cervical Squamous Intraepithelial Neoplasia 2|High Grade Cervical Intraepithelial Neoplasia National Cancer Institute (NCI) September 30 2019 Early Phase 1
NCT04859361 Active not recruiting Drug: Aldara 5% Topical Cream|Procedure: LLETZ Intraepithelial Neoplasia Cervical University Medical Centre Maribor November 20 2018 Not Applicable

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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