For research use only.

Catalog No.S4169 Synonyms: A77 1726, HMR-1726

13 publications

Teriflunomide Chemical Structure

CAS No. 163451-81-8, 108605-62-5

Teriflunomide (A77 1726, HMR-1726) is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.

Selleck's Teriflunomide has been cited by 13 publications

1 Customer Review

  • Leflunomide or teriflunomide were incubated with H1299, H460, A549 cells at indicated concentrations for or 2, 4 or 6 days, followed by MTT assay.

    Toxicol Lett, 2018, 282:154-165. Teriflunomide purchased from Selleck.

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Biological Activity

Description Teriflunomide (A77 1726, HMR-1726) is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.
dihydroorotate dehydrogenase [1]
In vitro

Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes. [1]

In vivo Teriflunomide has demonstrated beneficial effects in two independent animal models of demyelinating disease. In the dark agouti rat model of experimental autoimmune encephalitis (EAE), teriflunomide administration results in clinical, histopathological, and electrophysiological evidence of efficacy both as a prophylactic and therapeutic agent. Similarly, in the female Lewis rat model of EAE, teriflunomide administration results in beneficial prophylactic and therapeutic clinical effects, with a delay in disease onset and symptom severity. [1]


Solubility (25°C)

In vitro DMSO 32 mg/mL (118.42 mM)
Water Insoluble
Ethanol ',1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 270.21


CAS No. 163451-81-8, 108605-62-5
Storage powder
in solvent
Synonyms A77 1726, HMR-1726
Smiles CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04799288 Not yet recruiting Drug: Teriflunomide HAM/TSP National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) September 7 2021 Phase 1|Phase 2
NCT04129736 Recruiting Drug: Teriflunomide 14 MG Multiple Sclerosis Pharmacokinetics Jan Lycke|Sahlgrenska University Hospital Sweden October 10 2019 Phase 4
NCT03526224 Completed Drug: Dimethyl Fumarate|Drug: Teriflunomide Tecfidera|Teriflunomide University at Buffalo June 14 2018 --
NCT03561402 Completed Drug: Teriflunomide Multiple Sclerosis Relapsing-Remitting McGill University December 1 2016 --
NCT02833714 Terminated -- RELAPSING REMITTING MULTIPLE SCLEROSIS University of North Carolina Chapel Hill|Genzyme a Sanofi Company January 2016 --
NCT02679885 Completed -- Multiple Sclerosis Griffin Hospital October 2015 --

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Frequently Asked Questions

  • Question 1:

    I am planning to use teriflunomide (S4169) in my in vivo protocol, but I cannot get a homogeneous solution. Could you please provide me with some guidance?

  • Answer:

    This compound is an oral clinical medicine. For oral administration suspension is fine. In paper http://www.pnas.org/content/108/44/18067.full, they also prepared the stock by DMSO and then diluted into 0.9% sterile saline for animial study.

Dehydrogenase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID