Prednisolone (NSC-9900)

For research use only.

Catalog No.S1737

11 publications

Prednisolone (NSC-9900) Chemical Structure

CAS No. 50-24-8

Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Selleck's Prednisolone (NSC-9900) has been cited by 11 publications

2 Customer Reviews

  • Combinations of EPZ-6438 with Prednisolone or Dexamethasone in DOHH2 EZH2 wild-type GCB lymphoma cell lines. All dose response plots were generated in Graphpad Prism and curves fitted to a four-parameter model with variable slope (2 biological replicates). Doses of EPZ-6438 ranged from 15.6-1000 nM, doses of Prednisolone ranged from 7.8–1000 nM, and doses of Dexamethasone ranged from
    0.8-100 nM. The potency of Prednisolone is increased with addition of EPZ-6438 in DOHH2 cells.

    PLoS One, 2014, 9(12):e111840.. Prednisolone (NSC-9900) purchased from Selleck.

    Inhibition of proliferation of CMV-specifi CD8+ T cells by everolimus. Isolated CD8+ T cells were labeled with CFSE and stimulated with CMVpp65 peptide in a MLPC in the presence of increasing doses of everolimus. After 6 days T cells were stained for CD8 expression and specifi city for the HLA-A2 restricted epitope pp65 (495-503) . The numbers show percentages of (B) tetramer-positive cells of total CD8+ T cells using fl ow cytometry. One representative histogram/dot blot out of six experiments is shown.

    Leuk Lymphoma, 2014, 55(5):1144-50. . Prednisolone (NSC-9900) purchased from Selleck.

Purity & Quality Control

Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Prednisolone (NSC-9900) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Glucocorticoid receptor [1]
In vitro

Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. [1] Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats. [2] Prednisolone's anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM) expression. Prednisolone (0.75 mg/kg) reduces macrophages (-59%, -57%), CD4(+) T-cells (-50%, -60%), CD8(+) T-cells (-58%, -48%), and eosinophils (-36%, -25%) in quadriceps and soleus muscles, respectively. Prednisolone-treated mice also exhibits decreased vascular P-selectin (-82%) and ICAM-1 (-52%) expression and fewer L-selectin (-79%) and ICAM-1 (-57%) expressing mononuclear cells in quadriceps. Prednisolone reduces sarcolemmal damage and degeneration as well in Dystrophin-deficient, mdx mice. [3]

In vivo Prednisolone (5 mg/kg) causes alterations in diaphragmatic contractile properties and histological changes without fiber atrophy in rats. Prednisolone results in an increased number of diaphragmatic bundles in rats. [4] Prednisolone induces a significant decline of PL-pO2, while CoBF, CMs, CAPs, and ABRs revealed no change in guinea pigs. [5]


Solubility (25°C)

In vitro DMSO 72 mg/mL (199.75 mM)
Water Insoluble
Ethanol '''10 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 360.44


CAS No. 50-24-8
Storage powder
in solvent
Synonyms N/A
Smiles CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04874610 Recruiting Drug: Methylprednisolone Pediatric Obesity|Asthma in Children Duke University August 16 2021 --
NCT04965636 Not yet recruiting Drug: Mepolizumab Hypereosinophilic Syndrome GlaxoSmithKline August 31 2021 Phase 3
NCT05001737 Not yet recruiting Drug: Emapalumab Macrophage Activation Syndrome|Secondary Hemophagocytic Lymphohistiocytosis|Still Disease|Systemic Lupus Erythematosus Swedish Orphan Biovitrum August 10 2021 Phase 3
NCT05006703 Recruiting Behavioral: Breathe4T Adolescent Behavior|Asthma University of Southampton|University of Bath|Aston University|University Hospital Southampton NHS Foundation Trust|Asthma UK June 22 2021 Not Applicable
NCT04797325 Not yet recruiting Drug: Vedolizumab|Drug: Prednisolone Immune-Mediated Colitis University of Copenhagen April 2021 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID