Fenoprofen calcium hydrate

Catalog No.S3027

Fenoprofen calcium hydrate Chemical Structure

Molecular Weight(MW): 558.63

Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).

Size Price Stock Quantity  
In DMSO USD 610 In stock
USD 97 In stock
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Biological Activity

Description Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).
In vitro

Fenoprofen is a more potent inhibitor of collagen-induced platelet aggregation than either aspirin or phenylbutazone. [1] Fenoprofen inhibits the formation of palmitoyl-CoA in both microsomal and peroxisomal fractions, and inhibits the beta-oxidation of lignoceric acid and cerotic acid in rat hepatocytes. [5] Fenoprofen exhibits modest antiproliferative activity against HT-29, DID-1, and SW480 cells with IC50 of 240 μM, 300 μM, and 360 μM, respectively. [6] Fenoprofen (0.1 mM) is an efficient activator of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to a degree comparable to that obtained with the PPARγ ligands BRL49653 and 15-deoxy-D12,14-PGJ2 and the peroxisome proliferator Wy14643. Fenoprofen is also an efficacious activator of PPARα, activating the receptor to a degree comparable to that obtained with the strong peroxisome proliferator Wy14643. Consistently, Fenoprofen treatment promotes lipogenesis in C3H10T1/2 cells. [7] Although Fenoprofen displays only modest antiproliferative activity, Fenoprofen amides can potently induce cell cycle arrest at the G1 phase, as well as apoptosis, probably because of a greater lipophilicity and/or better cell uptake. [9]

In vivo Oral administration of Fenoprofen at 50 mg/kg potently inhibits thrombus formation by 47%, whereas a dose of 200 mg/kg of aspirin is required to reduce thrombus formation 21 %. [1] Similar to indomethacin, adminstration of Fenoprofen inhibits prostaglandin synthesis. [2] In rats with type II collagen-induced arthritis, Fenoprofen treatment at 40 mg/kg/day partially suppresses the paw swelling, but has no significant effect on humoral and cellular responses. [3] Administration of Fenoprofen depresses the rebound contraction, thus transforming the brisk relaxant response, elicited by vagal stimulation or ATP, into long-lasting relaxation. [4] Administration of Fenoprofen causes a strong and dose-related induction of peroxisomal palmitoyl-CoA oxidase, and of carnitine acyltransferase and acyl-CoA hydrolase activities in liver homogenates of mice fed diets. Hepatic catalase activity is significantly increased in mice fed the diet with 0.05 and 0.1% fenoprofen but not the 1% fenoprofen-containing diet. [8]


Cell Research:[6]
+ Expand
  • Cell lines: HT-29, DID-1, and SW480
  • Concentrations: Dissolved in DMSO, final concentrations ~1 mM
  • Incubation Time: 6 days
  • Method: Cells are exposed to various concentrations of Fenoprofen for 6 days. Cell number is determined using the SRB colonimetnic protein stain assay. After 6 days of culture, cells are fixed by the addition of cold trichloroacetic acid to a final concentration of 10%. Plates are incubated at 4 °C for 1 hour, then the supernatant is aspirated and the plates are washed with deionized water. SRB solution is formulated to 0.4% w/v in 1% acetic acid; 100 μL is added to each well and the plates are incubated for 10 minutes at room temperature. Unbound SRB is removed by washing with 1% acetic acid followed by air drying. Bound stain is solubilized with 50 mM unbuffered Tris and absorbance is read by an automated spectrophotometer at a single wavelength of 540 nm.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Guinea pigs with induced thrombus formation
  • Formulation: Dissolved in saline
  • Dosages: ~200 mg/kg
  • Administration: Orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 48 mg/mL (85.92 mM)
Ethanol 18 mg/mL (32.22 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 558.63


CAS No. 71720-56-4
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID