Home Immunology & Inflammation Immunology & Inflammation related chemical Loxoprofen

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Loxoprofen Immunology & Inflammation related chemical

Cat.No.S4682

Loxoprofen (Koloxo, Loxoprofene, Loxoprofeno) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
Loxoprofen Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 246.30

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Quality Control

Batch: S468201 DMSO]49 mg/mL]false]Ethanol]49 mg/mL]false]Water]Insoluble]false Purity: 99.81%
99.81

Solubility

In vitro
Batch:

DMSO : 49 mg/mL (198.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 49 mg/mL

Water : Insoluble

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In vivo
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 246.30 Formula

C15H18O3

 Storage (From the date of receipt)
CAS No. 68767-14-6 Download SDF Storage of Stock Solutions

Synonyms Koloxo, Loxoprofene, Loxoprofeno Smiles CC(C1=CC=C(C=C1)CC2CCCC2=O)C(=O)O

Mechanism of Action

In vitro
Loxoprofen sodium(LOX) does not affect the proliferation and viability of LLC cells in vitro. HUVECs treated with this compound results in the inhibition of the tubular formation. Treatment with 50 mg/ml this chemical reveals a 33% decline in in vitro angiogenesis, compared with vehicle-treated HUVECs. This inhibition is presumably due to inhibition of VEGF activity.
In vivo
Loxoprofen sodium (LOX), inhibits in vivo growth of implanted Lewis lung carcinoma (LLC). Intratumoral vessel density in this compound-treated mice is significantly lower than that of mice without treatment. Intratumoral expressions of vascular endothelial growth factor (VEGF) mRNA are attenuated by the LOX treatment. This chemical suppresses both intratumoral and systemic VEGF protein in LLC-implanted mice. It also inhibits tubular formation of primary cultured human umbilical vein endothelial cells, presumably due to the inhibition of VEGF. In patients with advanced non-small cell lung cancer, this medication (120 mg/day) for a week significantly decreases the plasma VEGF level.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00676117 Completed
Healthy
AstraZeneca
 April 2008 Phase 1

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