Catalog No.S4682 Synonyms: Koloxo, Loxoprofene, Loxoprofeno

Loxoprofen Chemical Structure

Molecular Weight(MW): 246.30

Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.

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Biological Activity

Description Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
In vitro

Loxoprofen sodium(LOX) does not affect the proliferation and viability of LLC cells in vitro. HUVECs treated with LOX results in the inhibition of the tubular formation. Treatment with 50 mg/ml LOX reveals a 33% decline in in vitro angiogenesis, compared with vehicle-treated HUVECs. This inhibition is presumably due to inhibition of VEGF activity[1].

In vivo Loxoprofen sodium (LOX), inhibits in vivo growth of implanted Lewis lung carcinoma (LLC). Intratumoral vessel density in LOX-treated mice is significantly lower than that of mice without treatment. Intratumoral expressions of vascular endothelial growth factor (VEGF) mRNA are attenuated by the LOX treatment. LOX suppresses both intratumoral and systemic VEGF protein in LLC-implanted mice. LOX also inhibits tubular formation of primary cultured human umbilical vein endothelial cells, presumably due to the inhibition of VEGF. In patients with advanced non-small cell lung cancer, LOX medication (120 mg/day) for a week significantly decreases the plasma VEGF level[1].


Cell Research:


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  • Cell lines: LLC cells
  • Concentrations: 50 μg/ml
  • Incubation Time: 0-6 days
  • Method:

    To determine the proliferation of LLC cells with or without Loxoprofen, 2×104 cells are seeded into 100-mm dishes containing 10 ml culture medium supplemented with 50 μg/ml Loxoprofen or vehicle on day 0. On days 2, 3, 4 and 6, the cells are trypsinized and counted.

    (Only for Reference)
Animal Research:


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  • Animal Models: C57BL/6 and BDF1 mice
  • Formulation: water
  • Dosages: 60 μg/ml
  • Administration: via drinking water
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 49 mg/mL (198.94 mM)
Ethanol 49 mg/mL (198.94 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 246.30


CAS No. 68767-14-6
Storage powder
in solvent
Synonyms Koloxo, Loxoprofene, Loxoprofeno

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02983747 Active not recruiting Low Back Pain Shanghai Changzheng Hospital November 2016 Not Applicable
NCT02831569 Completed Pain Boehringer Ingelheim|SSP Co. Ltd. July 27 2016 Phase 3
NCT02616068 Completed Trauma|Pain Daiichi Sankyo Brasil Farmacêutica LTDA|Quintiles Inc.|Daiichi Sankyo Co. Ltd. October 2015 Phase 3
NCT02602353 Completed Delayed Onset Muscle Soreness Lead Chemical Co.Ltd.|Cardinal Health October 2015 Phase 2
NCT02467504 Unknown status Rheumatoid Arthritis Peking University People''s Hospital|Monash University|Beijing ShuangLu Pharmaceutical Co. Ltd. July 2015 Phase 2
NCT01922466 Completed Chronic Non-specific Uncomplicated Neck Pain Kyunghee University Medical Center|Kyung Hee University Hospital at Gangdong|Kyunghee University|Korea Institute of Oriental Medicine July 2013 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID