Pentosan Polysulfate Sodium

Synonyms: PPS, Elmiron

Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity.

Pentosan Polysulfate Sodium Chemical Structure

Pentosan Polysulfate Sodium Chemical Structure

CAS No. 140207-93-8

Purity & Quality Control

Pentosan Polysulfate Sodium Related Products

Biological Activity

Description Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also exhibits anti-HIV-1 activity.
Targets
HIV-1 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06334523 Not yet recruiting
Extremely Low Birthweight Infant|Continuous Tracheal Gas Insufflation|Medical Device|Lung Protection|Ventilator-Induced Lung Injury
Centre Hospitalier Intercommunal Creteil
May 1 2024 Phase 2
NCT06375876 Not yet recruiting
Domestic Violence
Yale University|Office on Violence Against Women (OVW)
April 2024 Not Applicable
NCT05900336 Recruiting
Dysmenorrhea|Menstrual Pain|Non-steroidal Anti-inflammatory Drug
Mclean Hospital|United States Department of Defense|NorthShore University HealthSystem
March 25 2024 Phase 4

Chemical Information & Solubility

Molecular Weight Formula

(C5H6Na2O10S2)n

CAS No. 140207-93-8 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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