Geniposidic acid

For research use only.

Catalog No.S2413

3 publications

Geniposidic acid Chemical Structure

CAS No. 27741-01-1

Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.

Size Price Stock Quantity  
10mM (1mL in DMSO) EUR 127 In stock
EUR 88 In stock
EUR 265 In stock
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Selleck's Geniposidic acid has been cited by 3 publications

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Biological Activity

Description Geniposidic acid is an iridoid glucoside, used to treat inflammation, jaundice and hepatic disorders.
In vivo Geniposidic acid shows a more remarkable inhibitory activity factor against implanted tumor growth when the doses of 500 mg/kg are given alone or combined with irradiation. [1] Geniposidic acid improves the plaque area, intima/media thickness ratio, and intimal foam cells number in rabbits. Geniposidic acid (100 μg/mL) results in relieving ECs shedding and improving aortic morphology disorders in rabbits. Geniposidic acid (100 μg/mL) performs significant inhibition on smooth muscle cells proliferation in rabbits. Geniposidic acid results in obvious inhibition on SMC migration from the upper chamber. [2] Geniposidic acid increases survival rate of rats with fulminant hepatic failure. Geniposidic acid attenuates the following effects: GalN/LPS increases serum aminotransferase activity, serum tumor necrosis factor-α level and hepatic lipid peroxidation and decreases hepatic glutathione content. Geniposidic acid augmentes increases in serum interleukin-6 level, heme oxygenase-1 and NF-E2-related factor 2 protein expression in rats with fulminant hepatic failure. Geniposidic acid decreases cleaved caspase-8 and caspase-3 protein expression and shows significantly fewer apoptotic cells in rats with fulminant hepatic failure. Geniposidic acid increases Bcl-xL protein expression and decreased Bax protein expression in rats with fulminant hepatic failure. Geniposidic acid treatment enhances phosphorylation of signal transducer and activator of transcription 3 in rats with fulminant hepatic failure. [3]


Solubility (25°C)

In vitro DMSO 16 mg/mL (42.74 mM)
Ethanol 2 mg/mL (5.34 mM)
Water Insoluble

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Chemical Information

Molecular Weight 374.34


CAS No. 27741-01-1
Storage powder
in solvent
Synonyms N/A
Smiles C1C=C(C2C1C(=COC2OC3C(C(C(C(O3)CO)O)O)O)C(=O)O)CO

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID