For research use only.
Catalog No.S2910 Synonyms: 4-Hydroxy-TEMPO
CAS No. 2226-96-2
Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
Selleck's Tempol has been cited by 11 publications
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|Description||Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.|
Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage.  Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. 
|In vivo||Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat.  Tempol prevents cerebral vessel remodeling in hypertensive rats.  Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats.  Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. |
-  Mitchell JB, et al. Arch Biochem Biophys, 1991, 289(1), 62-70.
-  Gariboldi MB, et al. Free Radic Biol Med, 2000, 29(7), 633-641.
-  Chatterjee PK, et al. Kidney Int, 2000, 58(2), 658-673.
|In vitro||DMSO||34 mg/mL (197.39 mM)|
|Water||34 mg/mL (197.39 mM)|
|Ethanol||34 mg/mL (197.39 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
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* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
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