Tempol
Catalog No.S2910 Synonyms: 4-Hydroxy-TEMPO
Molecular Weight(MW): 172.24
Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
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Biological Activity
| Description | Tempol is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2. |
|---|---|
| In vitro |
Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. [1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. [2] |
| In vivo | Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. [3] Tempol prevents cerebral vessel remodeling in hypertensive rats. [4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. [5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. [6] |
Protocol
| Cell Research:[2] |
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| Animal Research:[3] |
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Solubility (25°C)
| In vitro | DMSO | 34 mg/mL (197.39 mM) |
|---|---|---|
| Water | 34 mg/mL (197.39 mM) | |
| Ethanol | 34 mg/mL (197.39 mM) | |
| In vivo | Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): Saline For best results, use promptly after mixing. |
30 mg/mL |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 172.24 |
|---|---|
| Formula | C9H18NO2 |
| CAS No. | 2226-96-2 |
| Storage | powder |
| in solvent | |
| Synonyms | 4-Hydroxy-TEMPO |
Bio Calculators
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Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03480971 | Not yet recruiting | Mucositis|Nephrotoxicity|Ototoxicity | Matrix Biomed Inc.|University of Maryland | October 2018 | Phase 2 |
| NCT00801086 | Unknown status | Alopecia | Mitos Pharmaceuticals | November 2008 | Phase 2 |
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