Home Immunology & Inflammation Immunology & Inflammation related modulator Y-320 For research use only.

Y-320

Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.

Y-320 Chemical Structure

Y-320 Chemical Structure

CAS: 288250-47-5

Selleck's Y-320 has been cited by 4 publications

Purity & Quality Control

Batch: S751601 DMSO] 11 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.52%
99.52

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Biological Activity

Description Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
In vitro
In vitro Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb. [1]
In Vivo
In vivo Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice. [1]
Animal Research Animal Models DBA/1J mice with type II collagen-induced arthritis (CIA)
Dosages ~3 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 505.01 Formula

C27H29ClN6O2
CAS No. 288250-47-5 SDF Download Y-320 SDF
Smiles CC1=C(C=NN1C2=CC=C(C=C2)Cl)C(=O)NC3=CC(=C(C=C3)N4CCC(CC4)N5CCOCC5)C#N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 11 mg/mL ( (21.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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