| S1208 |
Doxorubicin (Adriamycin) Hydrochloride
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Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase II with IC50 of 2.67 μM. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.This product may precipitate when dissolved in PBS solution. It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution.Doxorubicin (Adriamycin) HCl can be used to induce animal models of kidney disease.
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Cell Res, 2025, 35(6):437-452.
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Nat Commun, 2025, 16(1):8873
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Nat Commun, 2025, 16(1):509
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| S5159 |
Doxycycline
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Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
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Nature, 2025, 10.1038/s41586-025-09222-5
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Cell Stem Cell, 2025, S1934-5909(25)00181-X
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Nat Commun, 2025, 16(1):7898
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| S7894 |
Tunicamycin
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Tunicamycin, an antibiotic, can potently inhibit the N-linked glycosylation (NLG) by competitively inhibiting UDP-GlcNAc-dolichol-phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) activity and can target several types of tumors by reducing angiogenesis, inhibiting colony formation, and enhancing TRAIL-induced apoptosis.
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Proc Natl Acad Sci U S A, 2025, 122(22):e2505975122
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Cell Rep, 2025, 44(5):115686
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Eur Endod J, 2024, 9(4):335-343
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| S4226 |
Minocycline HCl
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Minocycline HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
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Cell Rep, 2025, 44(8):116015
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Hum Cell, 2025, 38(4):110
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Hum Cell, 2025, 38(4):110
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| S3028 |
G418 Sulfate (Geneticin)
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Geneticin (G418 Sulfate), an aminoglycoside antibiotic, is an elongation inhibitor of 80 S ribosomes that blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.It is commonly used as a screening reagent for eukaryotic cells to screen transfected or transformed cells.
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Signal Transduct Target Ther, 2025, 10(1):323
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Nat Commun, 2025, 16(1):10256
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J Hematol Oncol, 2024, 17(1):78
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| E4996 |
Puromycin
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Puromycin (CL13900, Puromycine) is an antibiotic, analog of the 3' end of aminoacyl-tRNA and an inhibitor of protein synthesis that mimics tyrosyl-tRNA, causing premature termination of translation. It blocks translation by labeling and releasing elongating polypeptide chains from ribosomes and has been widely used in molecular biology research.
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Nat Genet, 2025, 57(3):680-693
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Nat Commun, 2025, 16(1):10324
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Nat Commun, 2025, 16(1):8478
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| S1408 |
Linezolid (PNU-100766)
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Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.
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Commun Biol, 2025, 8(1):1261
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Molecules, 2023, 28(6)2820
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Molecules, 2023, 28(6), 2820
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| E2894 |
Penicillin-Streptomycin
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Penicillin-Streptomycin is used to prevent microbial contamination of cell culture during long-term in vitro cell culture maintenance. 100× solution stabilized with 10,000 units penicillin and 10 milligrams streptomycin per milliliter, suitable for cell culture applications.
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Mol Ther, 2025, S1525-0016(25)00543-X
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Hum Reprod Open, 2025, 2025(3):hoaf051
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J Lipid Res, 2025, S0022-2275(25)00216-0
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| S6068 |
Doxycycline monohydrate
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Doxycycline is a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity.
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iScience, 2024, 27(3):109265
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Mol Cancer, 2022, 21(1):43
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Theranostics, 2022, 12(7):3131-3149
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| S2527 |
Methacycline HCl
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Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.
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iScience, 2024, 27(10):110862
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J Pers Med, 2022, 12(2)258
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Hum Cell, 2022, 10.1007/s13577-022-00671-y
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