Antibiotics

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Catalog No. Product Name Information Product Use Citations Product Validations
E0656New 7-Methylcoumarin 7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.
S1228 Idarubicin HCl Idarubicin HCl (4-demethoxydaunorubicin, NSC256439, 4-DMDR) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. Idarubicin induces mTOR-dependent cytotoxic autophagy.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cancers (Basel), 2021, 13(14)3586
Biomolecules, 2021, 11(8)1128
S1611 Cefoperazone Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.
S1791 Bacitracin Zinc Bacitracin is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
S2527 Methacycline HCl Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 10.1007/s13577-021-00639-4
Hum Cell, 2021, 34(6):1911-1918
S2908 Hygromycin B Hygromycin B (Hygrovetine), a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome.
Autophagy, 2021, 1-17
PLoS Pathog, 2021, 17(4):e1009530
Cell Res, 2020,
S3028 Geneticin (G418 Sulfate) Geneticin (G418 Sulfate), an aminoglycoside antibiotic, is an elongation inhibitor of 80 S ribosomes that blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
Breast Cancer Res Treat, 2022, 10.1007/s10549-021-06433-y
Cell Cycle, 2022, 1-17
Sci Adv, 2021, 7(7)eabd2645
S3496 Lefamulin acetate (Xenleta) Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.
J Biol Chem, 2022, 298(5):101909
S4425 Rifamycin S Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.
S4436 Pleuromutilin Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.
S4488 Delafloxacin Meglumine Delafloxacin (ABT-492, RX-3341, WQ-3034, Baxdela) meglumine is a broad-spectrum fluoroquinolone antibiotic against multiple pathogens.
S4490 Tetracycline Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.
S4647 Cefmenoxime hydrochloride Cefmenoxime (SCE-1365), a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly.
S4783 Benzyl isothiocyanate Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.
Biomolecules, 2019, 9(12)
S4941 Farnesol Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects.
S4974 Oxacillin sodium Oxacillin sodium (salt) is a narrow-spectrum β-lactam antibiotic that can be used for treatment of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia.
S4979 Procaine penicillin G Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R), a crystalline complex combining penicillin G with procaine, is a β-lactam antibiotic.
S5008 Ciprofloxacin hydrochloride Ciprofloxacin (CPX, Cetraxal, Ciloxan, Cipro, Bay-09867) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).
S5199 Oxytetracycline hydrochloride Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
Front Microbiol, 2016, 7:1765
S6549 PBTZ169 PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1.
Cell Death Dis, 2019, 10(4):319
S6584 Amdinocillin Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms.
S7046 Brefeldin A Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.
Nat Cell Biol, 2022, 24(5):766-782
Cell Mol Immunol, 2022, 10.1038/s41423-022-00841-w
PLoS One, 2022, 17(3):e0265805
S7417 Puromycin (CL13900) 2HCl Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
Signal Transduct Target Ther, 2022, 7(1):97
Nat Commun, 2022, 13(1):478
J Hematol Oncol, 2022, 15(1):30
S7419 Blasticidin S HCl Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.
Nat Commun, 2022, 13(1):478
Cancer Commun (Lond), 2022, 10.1002/cac2.12311
Theranostics, 2021, 11(6):2966-2986
S7784 Fumagillin Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.
E0706New Gemifloxacin mesylate Gemifloxacin mesylate (SB265805 mesylate; LB20304 mesylate) is a novel fluoronaphthyridone with a broad spectrum of antimicrobial activity and enhances activity against gram-positive aerobes.
S1208 Doxorubicin (Adriamycin) HCl Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.
Adv Sci (Weinh), 2022, e2103332
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Bioact Mater, 2022, 18:459-470
S1370 Biapenem Biapenem (L-627, LJC10627) is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains.
S1371 Cefoselis Sulfate Cefoselis (FK 037) is a widely used beta-lactam antibiotic.
S1373 Daptomycin (LY146032) Daptomycin (LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.
Comput Struct Biotechnol J, 2022, 20:2442-2454
J Phys Chem B, 2021, 125(22):5775-5785
Sci Adv, 2020, 6(34):eaba8968
S1374 Doripenem Hydrate Doripenem Hydrate (S-4661) is an ultra-broad-spectrum injectable antibiotic, used to treat complicated intra-abdominal infections and complicated urinary tract infections.
ACS Chem Biol, 2018, 13(8):2020-2026
S1381 Meropenem Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic.
S1395 Polymyxin B sulphate Polymyxin B (Aerosporin, PMB, Poly-RX) is an antibiotic primarily used for resistant gram-negative infections.
Free Radic Biol Med, 2019, 137:24-36
S1399 Teicoplanin Teicoplanin (Teichomycin) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.
ACS Appl Mater Interfaces, 2020, 12(14):16150-16158
Clin Exp Dent Res, 2016, 2(1):35-43
S1408 Linezolid (PNU-100766) Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.
Front Microbiol, 2020, 11:265
J Mol Cell Biol, 2019, pii: mjz020
PLoS One, 2019, 14(10):e0222970
S1450 Nanchangmycin Nanchangmycin is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants.
Elife, 2022, 11e74513
Antimicrob Agents Chemother, 2020, 1;AAC.00289-20
Sci Rep, 2019, 9(1):1144
S1499 Cefaclor Cefaclor (Cefachlor, Cefaclorum) is a cephalosporin antibiotic.
S1502 Cephalexin Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.
Clin Cancer Res, 2018, 24(3):659-673
Theranostics, 2017, 7(7):2092-2107
Blood Cancer J, 2017, 10.1038/bcj.2017.61
S1505 Aztreonam Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.
PLoS Pathog, 2016, 12(10):e1005932
Expert Opinion on Orphan Drugs, 2013, 1(7):549-556
S1605 Cefdinir Cefdinir (FK 482, PD 134393, CI-983) is an oral cephalosporin antibiotic, used to treat bacterial infections in many different parts of the body.
S1635 Erythromycin Erythromycin (E-Mycin) is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).
J Med Chem, 2018, 61(9):4189-4202
Oncotarget, 2018, 9(40):26086-26095
S1636 Amphotericin B Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
Stem Cell Res Ther, 2021, 12(1):485
ACS Omega, 2021, 6(12):8477-8487
Nat Microbiol, 2020, 10.1038/s41564-020-00790-y
S1741 Rifabutin (LM427) Rifabutin (LM427, Ansamycin) is a semisynthetic ansamycin antibiotic, used in the treatment of Mycobacterium avium intracellulare (MAI) and tuberculosis.
Antibiotics (Basel), 2020, 9(2)
Antimicrob Agents Chemother, 2020, AAC.00363-20
S1768 Cefditoren Pivoxil Cefditoren Pivoxil (ME-1207) is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria.
S1770 Sulfadiazine Sulfadiazine is a sulfonamide antibiotic.
S1773 Oxytetracycline (Terramycin) Oxytetracycline is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria.
Sci Rep, 2018, 8(1):7653
Front Microbiol, 2016, 7: 1765
S1777 Ethionamide Ethionamide (Bayer 5312) is an antibiotic used in the treatment of tuberculosis.
S1835 Azithromycin (CP-62993) Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
J Cell Biochem, 2022, 10.1002/jcb.30213
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 34(6):1911-1918
S1884 Sparfloxacin Sparfloxacin (AT-4140, CI-978, PD 131501) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.
S1915 Sulfamethoxazole Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.
S1977 Sarafloxacin HCl Sarafloxacin HCl (A-56620) is a hydrochloride salt form of sarafloxacin which is a quinolone antibiotic drug with IC50 of 0.96 μg/L.
S1998 D-Cycloserine D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.
S2048 Clindamycin Phosphate Clindamycin Phosphate (NSC 618653) is a lincosamide antibiotic for Plasmodium falciparum with IC50 of 12 nM.
S2052 Oxytetracycline Dihydrate Oxytetracycline Dihydrate is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
Front Microbiol, 2016, 7:1765
S2152 Sitafloxacin Hydrate Sitafloxacin Hydrate (DU-6859a) is a new-generation, broad-spectrum oral fluoroquinolone antibiotic.
Interact Cardiovasc Thorac Surg, 2018, 10.1093/icvts/ivy209
mSphere, 2018, 3(5)
S2159 Tebipenem Pivoxil Tebipenem pivoxil (L-084, ME1211) is an oral carbapenem antibiotic, use to treat otolaryngologic and respiratory infections.
S2315 Kanamycin sulfate Kanamycin sulfate (Kanamycin monosulfate, Ophtalmokalixan) is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections.
Oncotarget, 2018, 9(40):26086-26095
S2385 Hordenine Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties.
S2506 Roxithromycin Roxithromycin (Roxl-150) is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections.
Chemistry, 2020, 10.1002/chem.201905599
J Med Chem, 2018, 61(9):4189-4202
S2510 Spectinomycin 2HCl Spectinomycin 2HCl (Actinospectacin) is a new parenteral antibiotic prepared from Streptomyces spectabilis.
Cell Rep, 2020, 32(2):107897
S2514 Tobramycin Tobramycin (NSC 180514) is an aminoglycoside antibiotic with an IC50 of 9.7 μM.
Oncotarget, 2018, 9(40):26086-26095
S2530 7-Aminocephalosporanic acid 7-Aminocephalosporanic acid is used for synthesis of cephalosporin antibiotics and intermediates.
S2539 Lomefloxacin HCl Lomefloxacin HCl is a hydrochloride salt of lomefloxacin and is a fluoroquinolone antibiotic.
Front Microbiol, 2020, 10:2936
S2543 Ceftiofur HCl Ceftiofur HCl (U-67279A) is a cephalosporin antibiotic, used to treat both Gram-positive and Gram-negative bacteria infection.
S2544 Cefprozil hydrate Cefprozil hydrate is a semi-synthetic broad-spectrum cephalosporin antibiotic, used to treat certain infections caused by bacteria, such as bronchitis and infections of the ears, throat, sinuses, and skin.
S2563 Oxacillin sodium monohydrate Oxacillin sodium monohydrate (Methicillin) is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.
S2565 Amoxicillin Sodium Amoxicillin Sodium (Clavulanate) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.
ChemMedChem, 2022, e202200043
PLoS Comput Biol, 2020, 16(12):e1008489
Toxicol Appl Pharmacol, 2015, 285(1):51-60
S2568 Neomycin sulfate Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.
Mol Cell, 2020, 22 pii: S1097-2765(20)30231-8
S2574 Tetracycline HCl Tetracycline HCl (NCI-c55561) is a hydrochloride salt of tetracycline that is a broad-spectrum polyketide antibiotic.
PLoS Pathog, 2020, 16;16(3):e1008341
Antiviral Res, 2020, 185:104993
Sci Rep, 2018, 8(1):7653
S2583 Thiamphenicol Thiamphenicol (Thiophenicol) is an antimicrobial antibiotic and a methyl-sulfonyl analogue of chloramphenicol.
S3015 Amoxicillin Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.
ChemMedChem, 2022, e202200043
PLoS Comput Biol, 2020, 16(12):e1008489
Toxicol Appl Pharmacol, 2015, 285(1):51-60
S3055 Besifloxacin HCl Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic.
S3059 Enrofloxacin Enrofloxacin (BAY-Vp2674, PD160788) is a fluoroquinolone antibiotic.
S3105 Nadifloxacin Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris.
Pharmaceutics, 2021, 13(8)1289
S3122 Amikacin hydrate Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections.
Molecules, 2019, 25(1)
S3129 Trimethoprim Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
S3162 Tylosin tartrate Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.
S3170 Ampicillin sodium Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.
Exp Ther Med, 2022, 23(3):216
Vet J, 2018, 234:24-26
S3179 Carbenicillin disodium Carbenicillin (BRL-2064) is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity.
S3193 Ticarcillin sodium Ticarcillin (AB 2288, BRL 2288) is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria.
S3636 Cefadroxil hydrate Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.
S3645 Kitasamycin Kitasamycin (Leucomycin) is a macrolide antibiotic. It has antimicrobial activity against a wide spectrum of pathogens.
S3650 Penicillin V potassium salt Phenoxymethylpenicillin, also known as penicillin V, is an antibiotic useful for the treatment of a number of bacterial infections. It acts by inhibiting the biosynthesis of cell-wall peptidoglycan.
S3672 Cefonicid sodium Cefonicid sodium (Monocid) is a cephalosporin antibiotic. It interferes with cell wall biosynthesis in bacteria, leading to lysis of the infectious organism.
S3708 Sulfachloropyridazine Sulfachloropyridazine is an antibiotic used to treat a variety of bacterial infections.
S3971 Fusidine Fusidine (Fusidic Acid), isolated from Fusidium coccineum, is a steroidal antibiotic that inhibits protein synthesis.
S4030 Gentamicin Sulfate Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.
Universitätsmedizin Berlin, 2021, 10.17169/refubium-29871
Cell, 2020, S0092-8674(20)31394-5
S4052 Netilmicin Sulfate Netilmicin Sulfate is a member of the aminoglycoside family of antibiotics.
J Cancer Res Clin Oncol, 2019, 145(6):1495-1507
S4056 Retapamulin Retapamulin (SB-275833) is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.
Pediatr Infect Dis J, 2021, 40(7):637-638
Hum Mol Genet, 2020, ddaa244
S4060 Erythromycin Ethylsuccinate Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.
S4082 Spiramycin Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).
Chemistry, 2020, 10.1002/chem.201905599
S4093 Bismuth Subcitrate Potassium Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.
Cell Rep, 2022, 38(6):110359
J Clin Invest, 2020, 130(7):3901-3918
S4122 Tilmicosin Tilmicosin (EL 870) is a macrolide antibiotic.
S4148 Ampicillin Trihydrate Ampicillin Trihydrate (NCI-C56086) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.
Bone Joint Res, 2020, 16;9(4):152-161
S4150 Orbifloxacin Orbifloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic.
S4156 Chlortetracycline HCl (NSC 13252) Chlortetracycline HCl (NSC 13252, 7-Chlorotetracycline, Aureomycin monohydrochloride) is the first identified tetracycline antibiotic.
S4158 Ceftriaxone disodium salt hemi (heptahydrate) Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.
J Neurochem, 2020, 155(4):370-389
J Neurochem, 2020, 155(4):370-389
S4160 Penicillin G Sodium Penicillin G Sodium (Benzylpenicillin) is a β-lactam antibiotic produced by Penicillin spp.
Cell Rep, 2015, 11(1):98-110
S4179 Mezlocillin Sodium Mezlocillin sodium is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.
S4183 Paromomycin Sulfate Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.
S4213 Dirithromycin Dirithromycin (LY-237216, ASE 136) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.
S4215 Ribostamycin Sulfate Ribostamycin (Vistamycin) is an aminoglycoside antibiotic, containing a neutral sugar moiety, and is produced by Streptomyces ribosidificus.
PLoS Pathog, 2020, 16;16(3):e1008341
Pathogens, 2019, 8(3)
S4222 Piperacillin Sodium Piperacillin (CL227193) is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.
Cancer Discov, 2020, CD-20-0160
Analytical Methods, 2018, 10.1039/C8AY00150B
S4226 Minocycline (CL 59806) HCl Minocycline (CL 59806) HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
Int J Mol Sci, 2022, 23(5)2793
Front Bioeng Biotechnol, 2022, 10:855755
Neuropharmacology, 2022, 207:108950
S4234 Capreomycin Sulfate Capreomycin Sulfate is a cyclic peptide antibiotic and thought to inhibit protein synthesis by binding to the 70S ribosomal unit.
Mol Cell Proteomics, 2019, 18(2):231-244
S4254 Apramycin Sulfate Apramycin Sulfate (Ai3-29795) is an aminoglycoside antibiotic, which binds to the deep groove of the RNA.
S4271 Isepamicin Sulphate Isepamicin Sulphate (Isepamicine, Isepamycin, sch21420) is an aminoglycoside antibiotic, which inhibits bacterial protein synthesis by targeting the bacterial 30S ribosomal subunit.
S4279 Demeclocycline HCl Demeclocycline HCl is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections.
J Biol Chem, 2020, 10.1074/jbc.RA119.011633.
Sci Rep, 2018, 8(1):7653
S4393 Cephapirin Sodium Cephapirin Sodium (Cefapirin) is the sodium salt form of cephapirin, a semi-synthetic, first-generation cephalosporin antibiotic with bactericidal activity.Cephapirin Sodium is effective against gram-negative and gram-positive organisms.
S4421 Josamycin Josamycin (EN-141, Kitasamycin A3, Leucomycin A3, Turimycin A5) is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.
S4517 Cefotaxime sodium Cefotaxime sodium salt is a third-generation cephalosporin antibiotic; broad-spectrum antibiotic with activity against numerous Gram-positive and Gram-negative bacteria.
S4523 Dihydrostreptomycin sulfate Dihydrostreptomycin sulfate is an aminoglycoside antibiotic, used to treat bacterial diseases in cattle, pigs and sheep. Dihydrostreptomycin is a derivative of streptomycin.
S4536 Nitrofurantoin Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.
S4540 Sisomicin sulfate Sisomicin sulfate is an aminoglycoside antibiotic, isolated from the fermentation broth of a new species of the genus Micromonospora.
S4585 Succinylsulfathiazole Succinylsulfathiazole (Succinylsulphathiazole), a sulfonamide, is an antibiotic.
S4594 Cephalothin sodium Cephalothin (Cefalotin, Cephalotin) sodium is a semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall.
S4595 Cefazolin Sodium Cefazolin Sodium (cefazoline, cephazolin, Ancef) is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
S4596 Cefixime Cefixime (Cefixima, Cefiximum, Cephoral, Cefspan, FR-17027, FK-027, CL-284635) is an antibiotic useful for the treatment of a number of bacterial infections. It is a third generation cephalosporin.
S4612 Dapson Dapson (Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS), also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.
S4641 Tedizolid Phosphate Tedizolid (TR-701FA) is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.
Sci Transl Med, 2019, 11(516)
S4663 Fusidate Sodium Fusidate Sodium (Fucidin, SQ-16360) is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.
S4671 Cefradine Cefradine (Cephradine, Sefril, Anspor, Velosef) is a semi-synthetic cephalosporin antibiotic.
S4720 Cefotaxime Cefotaxime is a third-generation cephalosporin antibiotic and has broad spectrum activity against Gram positive and Gram negative bacteria.
S4750 Sulfacetamide sodium salt hydrate Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.
S4812 Ceftizoxime Ceftizoxime is a semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. It is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
S4813 Cefuroxime axetil Cefuroxime axetil, a prodrug of the cephalosporin cefuroxime, is a second generation oral cephalosporin antibiotic with in vitro antibacterial activity against several gram-positive and gram-negative organisms.
S4833 Cefoxitin sodium Cefoxitin Sodium is the sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.
S4847 Faropenem Sodium Faropenem sodium is an orally active beta-lactam antibiotic that has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia.
S4848 Dalbavancin Dalbavancin (Zeven, BI 397, MDL 63397) is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci.
S4850 Flucloxacillin sodium Flucloxacillin sodium (Floxacillin sodium) is the sodium salt of flucloxacillin, a penicillin antibiotic used to treat bacterial infections.
S4865 Cefetamet pivoxil hydrochloride Cefetamet pivoxil hydrochloride is the hydrochloride salt form of cefetamet pivoxil, which is an oral third-generation cephalosporin antibiotic.
S4869 Sulfamethoxazole sodium Sulfamethoxazole sodium is an antibiotic used for bacterial infections.
S4870 Cefodizime Sodium Cefodizime Sodium, a third generation cephalosporin antibiotic, has broad-spectrum activity and is stable to most beta-lactamases.
S4885 Taurolidine Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.
S4978 Azathramycin Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose.
S4986 Latamoxef sodium Latamoxef sodium (Moxalactam Disodium, FestamoxinLy, Shiomarin, Ly 127935, 6059 S) is an antibiotic and has anti-bacterial and anti-inflammation effects.
S5035 6-Aminopenicillanic acid 6-Aminopenicillanic acid (6-APA) is the central component of penicillin β-lactam antibiotics which are generated by Penicillium. It is used as precursor for antibiotic compounds ampicillin and amoxicillin.
S5041 Difloxacin hydrochloride Difloxacin is a second-generation, synthetic fluoroquinolone antimicrobial antibiotic used in veterinary medicine.
S5048 Fosfomycin Disodium Fosfomycin (Phosphonemycin) is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.
S5051 Pipemidic acid Pipemidic acid (Acido pipemidico) is a pyridopyrimidine antibiotic derivative of piromidic acid with activity against gram-negative and some gram-positive bacteria.
Hum Mol Genet, 2020, ddaa244
S5070 Mupirocin calcium Mupirocin Calcium (Pseudomonic acid A) is the calcium salt form of mupirocin, a natural crotonic acid derivative extracted from Pseudomonas fluorescens,which inhibits bacterial protein synthesis and is used as an antibiotic.
S5108 Tylosin Tylosin (Fradizine, Tylocine, Tylosine, Tylosin A) is a macrolide-class broad spectrum antibiotic that's used in veterinary medicine to treat felines, canines and livestock.
S5159 Doxycycline Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
Mol Cancer, 2022, 21(1):43
Mol Cell, 2022, S1097-2765(22)00433-6
Theranostics, 2022, 12(7):3131-3149
S5206 Benzylpenicillin potassium Benzylpenicillin potassium (Penicillin G potassium) is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic.
S5207 Cephalexin Monohydrate Cephalexin is a semisynthetic cephalosporin antibiotic with antimicrobial activity.
S5208 Ciprofloxacin hydrochloride hydrate Ciprofloxacin Hydrochloride (Ciloxan, Ceprimax, Oftacilox) is the hydrochloride salt form of ciprofloxacin, which is an antibiotic used to treat a number of bacterial infections.
S5227 Erythromycin thiocyanate Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits and inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
S5268 Solithromycin Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.
S5278 Tedizolid (TR-700) Tedizolid is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria.
S5290 Ormetoprim Ormetoprim (OMP) is an antibiotic to prevent the spread of disease in freshwater aquaculture.
S5294 Cephalotin acid Cephalotin acid (Cephalothin, Cefalotin, Cephalothinum) is a cephalosporin antibiotic.
S5295 Lincomycin Hydrochloride Monohydrate Lincomycin hydrochloride monohydrate is a narrow-spectrum antibiotic used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
S5296 Cephradine monohydrate Cefradine is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.
S5298 Amoxicillin trihydrate Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.
ChemMedChem, 2022, e202200043
PLoS Comput Biol, 2020, 16(12):e1008489
S5299 Tosufloxacin p-Toluenesulfonate Hydrate Tosufloxacin (T-3262) is a fluoroquinolone antibiotic that is used to treat susceptible infections.
S5328 Gamithromycin Gamithromycin (ML-1709460) is a new macrolide antibiotic that is only registered for use in cattle to treat respiratory disorders such as bovine respiratory disease.
Hum Cell, 2020, 10.1007/s13577-020-00420-z
S5330 Amikacin Sulfate Salt Amikacin (BAY 41-6551) sulfate, a semisynthetic analog of kanamycin, is an aminoglycoside antibiotic which is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains.
S5333 Sulbenicillin Sodium Sulbenicillin Sodium (Sulfocillin, Sulfobenzylpenicillin) is the sodium salt of sulbenicillin, which is a penicillin antibiotic.
S5350 Cefpodoxime proxetil Cefpodoxime Proxetil is a third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity.
S5351 Cefmetazole sodium Cefmetazole sodium is a semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
S5353 Cefpiramide sodium Cefpiramide sodium (CPMS, SM-1652,wy-44635) is an anionic β-lactam antibiotic. It exhibits antibacterial activity against gram-positive and gram-negative bacteria, in particular, to Pseudomonas aeruginosa, which can result in achronic life-threatening infection in the lungs of cystic fibrosis patients.
S5410 Chloramphenicol sodium succinate Chloramphenicol Sodium Succinate is the sodium succinate salt form of chloramphenicol, a nitrobenzene derivate and broad-spectrum antibiotic with antibacterial activity.
Oncotarget, 2018, 9(40):26086-26095
S5417 Spectinomycin dihydrochloride pentahydrate Spectinomycin dihydrochloride pentahydrate (Trobicin) is a widely used antibiotic that inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome.
S5420 Clindamycin alcoholate Clindamycin alcoholate is a crystallizable compound of Clindamycin with alcohol. Clindamycin is a semisynthetic lincosamide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits.
S5421 Fluoroquinolonic Acid Fluoroquinolonic Acid (Ciprofloxacin Impurity A, Q-Acid) is an antibiotic and antimicrobial agent.
S5473 Pivmecillinam hydrochloride Pivmecillinam is a β-lactam antibiotic and a prodrug of mecillinam. It has selective activity against Gram-negative bacteria and is used primarily in the treatment of lower urinary tract infections.
S5487 Cefoperazone sodium Cefoperazone Sodium is the sodium salt form of cefoperazone, which is a semi-synthetic, broad-spectrum, beta-lactamase resistant antibiotic with bactericidal activity.
S5491 Lomefloxacin Lomefloxacin is a fluoroquinolone antibiotic used to treat bacterial infections.
S5515 Penicillin G Procaine Procaine benzylpenicillin (Procaine benzylpenicillin), also known as Procaine benzylpenicillin, is an antibiotic useful for the treatment of a number of bacterial infections.
S5531 Doripenem Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.
Biomed Chromatogr, 2017, 31(5)
S5533 Tobramycin sulfate Tobramycin sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity.
Oncotarget, 2018, 9(40):26086-26095
S5535 Moxifloxacin Moxifloxacin is an antibiotic used to treat a number of bacterial infections, active against Mycobacterium tuberculosis in vitro.
Transl Vis Sci Technol, 2018, 7(2):11
J Pharmacol Toxicol Methods, 2017, 90:39-47
Circ Arrhythm Electrophysiol, 2016, 9(4):e003655
S5560 Midecamycin Midecamycin (Espinomycin A, Medecamycin A1, Platenomycin B1, Rubimycin, Turimycin P3) is a naturally occuring macrolide antibiotic that acts by inhibiting bacterial protein synthesis.
S5573 Tilmicosin phosphate Tilmicosin phosphate is a macrolide antibiotic that is used to treat cattle for pathogens that cause Bovine Respiratory Disease.
S5601 Balofloxacin Dihydrate Balofloxacin Dihydrate is an orally active fluoroquinolone antibiotic.
S5637 Cefotiam Hexetil Hydrochloride Cefotiam Hexetil Hydrochloride is the hydrochloride salt of cefotiam hexetil. Cefotiam is a semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity.
S5644 Ceftriaxone Sodium Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity.
S5657 Ertapenem sodium Ertapenem Sodium (MK826) is the sodium salt of ertapenem, a long-acting, broad-spectrum antibiotic of β-lactam subclass.
S5719 Ceftizoxime sodium Ceftizoxime sodium is a semisynthetic cephalosporin antibiotic that is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
S5736 Benzathine penicilline Benzathine penicilline (Benzathine penicillin G) is an antibiotic useful for the treatment of a number of bacterial infections.
S5744 Spiramycin I Spiramycin I (Foromacidin A) is a main component of spiramycin, which is a macrolide antimicrobial agent with broad spectrum antibiotic activity.
S5784 Vancomycin Vancomycin is an antibiotic used to treat serious bacterial infections. It works by stopping the growth of bacteria.
Gut Microbes, 2020, 12(1):1-20
Oncotarget, 2018, 9(40):26086-26095
S5859 Sancycline Sancycline (Bonomycin, Norcycline, GS 2147) is a semi-synthetic tetracycline antibiotic.
S5936 Cefazolin Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
S5941 Besifloxacin Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis.
S5951 Cefoxitin Cefoxitin is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.
S5968 Kasugamycin hydrochloride hydrate Kasugamycin (Ksg) hydrochloride hydrate, an antibiotic which binds both the 30S and 70S ribosome, specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs.
S6068 Doxycycline monohydrate Doxycycline is a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity.
Mol Cancer, 2022, 21(1):43
Theranostics, 2022, 12(7):3131-3149
EMBO Rep, 2022, e52984
S6423 Tildipirosin Tildipirosin is a 16-membered ring, tribasic and semi-synthetic macrolide antibiotic.
Nat Cell Biol, 2017, 19(10):1274-1285
S6562 KKL-35 KKL-35 inhibits the trans-translation tagging reaction with an IC50 of 0.9 µM. It has broad-spectrum antibiotic activity.
S6582 Ozenoxacin Ozenoxacin is a quinolone antibiotic used for the treatment of impetigo.
S8871 Omadacycline tosylate Omadacycline tosylate is a first-in-class aminomethylcycline antibiotic, demonstrating antimicrobial activity in vitro against a range of Gram-positive and Gram-negative aerobes and some anaerobic bacteria.
E0656New 7-Methylcoumarin 7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.
S1228 Idarubicin HCl Idarubicin HCl (4-demethoxydaunorubicin, NSC256439, 4-DMDR) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. Idarubicin induces mTOR-dependent cytotoxic autophagy.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cancers (Basel), 2021, 13(14)3586
Biomolecules, 2021, 11(8)1128
S1611 Cefoperazone Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.
S1791 Bacitracin Zinc Bacitracin is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
S2527 Methacycline HCl Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 10.1007/s13577-021-00639-4
Hum Cell, 2021, 34(6):1911-1918
S2908 Hygromycin B Hygromycin B (Hygrovetine), a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome.
Autophagy, 2021, 1-17
PLoS Pathog, 2021, 17(4):e1009530
Cell Res, 2020,
S3028 Geneticin (G418 Sulfate) Geneticin (G418 Sulfate), an aminoglycoside antibiotic, is an elongation inhibitor of 80 S ribosomes that blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
Breast Cancer Res Treat, 2022, 10.1007/s10549-021-06433-y
Cell Cycle, 2022, 1-17
Sci Adv, 2021, 7(7)eabd2645
S3496 Lefamulin acetate (Xenleta) Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.
J Biol Chem, 2022, 298(5):101909
S4425 Rifamycin S Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.
S4436 Pleuromutilin Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.
S4488 Delafloxacin Meglumine Delafloxacin (ABT-492, RX-3341, WQ-3034, Baxdela) meglumine is a broad-spectrum fluoroquinolone antibiotic against multiple pathogens.
S4490 Tetracycline Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.
S4647 Cefmenoxime hydrochloride Cefmenoxime (SCE-1365), a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly.
S4783 Benzyl isothiocyanate Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.
Biomolecules, 2019, 9(12)
S4941 Farnesol Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects.
S4974 Oxacillin sodium Oxacillin sodium (salt) is a narrow-spectrum β-lactam antibiotic that can be used for treatment of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia.
S4979 Procaine penicillin G Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R), a crystalline complex combining penicillin G with procaine, is a β-lactam antibiotic.
S5008 Ciprofloxacin hydrochloride Ciprofloxacin (CPX, Cetraxal, Ciloxan, Cipro, Bay-09867) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).
S5199 Oxytetracycline hydrochloride Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
Front Microbiol, 2016, 7:1765
S6549 PBTZ169 PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1.
Cell Death Dis, 2019, 10(4):319
S6584 Amdinocillin Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms.
S7046 Brefeldin A Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.
Nat Cell Biol, 2022, 24(5):766-782
Cell Mol Immunol, 2022, 10.1038/s41423-022-00841-w
PLoS One, 2022, 17(3):e0265805
S7417 Puromycin (CL13900) 2HCl Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
Signal Transduct Target Ther, 2022, 7(1):97
Nat Commun, 2022, 13(1):478
J Hematol Oncol, 2022, 15(1):30
S7419 Blasticidin S HCl Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.
Nat Commun, 2022, 13(1):478
Cancer Commun (Lond), 2022, 10.1002/cac2.12311
Theranostics, 2021, 11(6):2966-2986
S7784 Fumagillin Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.
E0656New 7-Methylcoumarin 7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.
E0706New Gemifloxacin mesylate Gemifloxacin mesylate (SB265805 mesylate; LB20304 mesylate) is a novel fluoronaphthyridone with a broad spectrum of antimicrobial activity and enhances activity against gram-positive aerobes.
Tags: Antibiotics inhibitor|Antibiotics agonist|Antibiotics activator|Antibiotics inducer|Antibiotics antagonist|Antibiotics signaling pathway|Antibiotics assay kit