E0656New |
7-Methylcoumarin
|
7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity. |
|
|
S1228 |
Idarubicin HCl
|
Idarubicin HCl (4-demethoxydaunorubicin, NSC256439, 4-DMDR) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. Idarubicin induces mTOR-dependent cytotoxic autophagy. |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Cancers (Basel), 2021, 13(14)3586
-
Biomolecules, 2021, 11(8)1128
|
|
S1611 |
Cefoperazone
|
Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM. |
|
|
S1791 |
Bacitracin Zinc
|
Bacitracin is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
|
|
|
S2527 |
Methacycline HCl
|
Methacycline HCl (Rondomycin) is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections. |
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 10.1007/s13577-021-00639-4
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S2908 |
Hygromycin B
|
Hygromycin B (Hygrovetine), a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome. |
-
Autophagy, 2021, 1-17
-
PLoS Pathog, 2021, 17(4):e1009530
-
Cell Res, 2020,
|
|
S3028 |
Geneticin (G418 Sulfate)
|
Geneticin (G418 Sulfate), an aminoglycoside antibiotic, is an elongation inhibitor of 80 S ribosomes that blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. |
-
Breast Cancer Res Treat, 2022, 10.1007/s10549-021-06433-y
-
Cell Cycle, 2022, 1-17
-
Sci Adv, 2021, 7(7)eabd2645
|
|
S3496 |
Lefamulin acetate (Xenleta)
|
Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer. |
-
J Biol Chem, 2022, 298(5):101909
|
|
S4425 |
Rifamycin S
|
Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. |
|
|
S4436 |
Pleuromutilin
|
Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria. |
|
|
S4488 |
Delafloxacin Meglumine
|
Delafloxacin (ABT-492, RX-3341, WQ-3034, Baxdela) meglumine is a broad-spectrum fluoroquinolone antibiotic against multiple pathogens. |
|
|
S4490 |
Tetracycline
|
Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. |
|
|
S4647 |
Cefmenoxime hydrochloride
|
Cefmenoxime (SCE-1365), a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly. |
|
|
S4783 |
Benzyl isothiocyanate
|
Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. |
-
Biomolecules, 2019, 9(12)
|
|
S4941 |
Farnesol
|
Farnesol is a natural sesquiterpene alcohol that is potent in treating antimetabolic disorders, anti-inflammation, showing antioxidant, anticancer, and antibiotic effects. |
|
|
S4974 |
Oxacillin sodium
|
Oxacillin sodium (salt) is a narrow-spectrum β-lactam antibiotic that can be used for treatment of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia. |
|
|
S4979 |
Procaine penicillin G
|
Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R), a crystalline complex combining penicillin G with procaine, is a β-lactam antibiotic. |
|
|
S5008 |
Ciprofloxacin hydrochloride
|
Ciprofloxacin (CPX, Cetraxal, Ciloxan, Cipro, Bay-09867) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases). |
|
|
S5199 |
Oxytetracycline hydrochloride
|
Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins. |
-
Front Microbiol, 2016, 7:1765
|
|
S6549 |
PBTZ169
|
PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1. |
-
Cell Death Dis, 2019, 10(4):319
|
|
S6584 |
Amdinocillin
|
Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms. |
|
|
S7046 |
Brefeldin A
|
Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy. |
-
Nat Cell Biol, 2022, 24(5):766-782
-
Cell Mol Immunol, 2022, 10.1038/s41423-022-00841-w
-
PLoS One, 2022, 17(3):e0265805
|
|
S7417 |
Puromycin (CL13900) 2HCl
|
Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
|
-
Signal Transduct Target Ther, 2022, 7(1):97
-
Nat Commun, 2022, 13(1):478
-
J Hematol Oncol, 2022, 15(1):30
|
|
S7419 |
Blasticidin S HCl
|
Blasticidin S HCl is a nucleoside antibiotic isolated from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor, used to select transfected cells carrying bsr or BSD resistance genes.
|
-
Nat Commun, 2022, 13(1):478
-
Cancer Commun (Lond), 2022, 10.1002/cac2.12311
-
Theranostics, 2021, 11(6):2966-2986
|
|
S7784 |
Fumagillin
|
Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.
|
|
|
E0706New |
Gemifloxacin mesylate
|
Gemifloxacin mesylate (SB265805 mesylate; LB20304 mesylate) is a novel fluoronaphthyridone with a broad spectrum of antimicrobial activity and enhances activity against gram-positive aerobes. |
|
|
S1208 |
Doxorubicin (Adriamycin) HCl
|
Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation. |
-
Adv Sci (Weinh), 2022, e2103332
-
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
-
Bioact Mater, 2022, 18:459-470
|
|
S1370 |
Biapenem
|
Biapenem (L-627, LJC10627) is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains. |
|
|
S1371 |
Cefoselis Sulfate
|
Cefoselis (FK 037) is a widely used beta-lactam antibiotic. |
|
|
S1373 |
Daptomycin (LY146032)
|
Daptomycin (LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
-
Comput Struct Biotechnol J, 2022, 20:2442-2454
-
J Phys Chem B, 2021, 125(22):5775-5785
-
Sci Adv, 2020, 6(34):eaba8968
|
|
S1374 |
Doripenem Hydrate
|
Doripenem Hydrate (S-4661) is an ultra-broad-spectrum injectable antibiotic, used to treat complicated intra-abdominal infections and complicated urinary tract infections. |
-
ACS Chem Biol, 2018, 13(8):2020-2026
|
|
S1381 |
Meropenem
|
Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic. |
|
|
S1395 |
Polymyxin B sulphate
|
Polymyxin B (Aerosporin, PMB, Poly-RX) is an antibiotic primarily used for resistant gram-negative infections. |
-
Free Radic Biol Med, 2019, 137:24-36
|
|
S1399 |
Teicoplanin
|
Teicoplanin (Teichomycin) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria. |
-
ACS Appl Mater Interfaces, 2020, 12(14):16150-16158
-
Clin Exp Dent Res, 2016, 2(1):35-43
|
|
S1408 |
Linezolid (PNU-100766)
|
Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections. |
-
Front Microbiol, 2020, 11:265
-
J Mol Cell Biol, 2019, pii: mjz020
-
PLoS One, 2019, 14(10):e0222970
|
|
S1450 |
Nanchangmycin
|
Nanchangmycin is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants. |
-
Elife, 2022, 11e74513
-
Antimicrob Agents Chemother, 2020, 1;AAC.00289-20
-
Sci Rep, 2019, 9(1):1144
|
|
S1499 |
Cefaclor
|
Cefaclor (Cefachlor, Cefaclorum) is a cephalosporin antibiotic. |
|
|
S1502 |
Cephalexin
|
Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections. |
-
Clin Cancer Res, 2018, 24(3):659-673
-
Theranostics, 2017, 7(7):2092-2107
-
Blood Cancer J, 2017, 10.1038/bcj.2017.61
|
|
S1505 |
Aztreonam
|
Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection. |
-
PLoS Pathog, 2016, 12(10):e1005932
-
Expert Opinion on Orphan Drugs, 2013, 1(7):549-556
|
|
S1605 |
Cefdinir
|
Cefdinir (FK 482, PD 134393, CI-983) is an oral cephalosporin antibiotic, used to treat bacterial infections in many different parts of the body. |
|
|
S1635 |
Erythromycin
|
Erythromycin (E-Mycin) is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml). |
-
J Med Chem, 2018, 61(9):4189-4202
-
Oncotarget, 2018, 9(40):26086-26095
|
|
S1636 |
Amphotericin B
|
Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes. |
-
Stem Cell Res Ther, 2021, 12(1):485
-
ACS Omega, 2021, 6(12):8477-8487
-
Nat Microbiol, 2020, 10.1038/s41564-020-00790-y
|
|
S1741 |
Rifabutin (LM427)
|
Rifabutin (LM427, Ansamycin) is a semisynthetic ansamycin antibiotic, used in the treatment of Mycobacterium avium intracellulare (MAI) and tuberculosis. |
-
Antibiotics (Basel), 2020, 9(2)
-
Antimicrob Agents Chemother, 2020, AAC.00363-20
|
|
S1768 |
Cefditoren Pivoxil
|
Cefditoren Pivoxil (ME-1207) is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria. |
|
|
S1770 |
Sulfadiazine
|
Sulfadiazine is a sulfonamide antibiotic. |
|
|
S1773 |
Oxytetracycline (Terramycin)
|
Oxytetracycline is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria. |
-
Sci Rep, 2018, 8(1):7653
-
Front Microbiol, 2016, 7: 1765
|
|
S1777 |
Ethionamide
|
Ethionamide (Bayer 5312) is an antibiotic used in the treatment of tuberculosis. |
|
|
S1835 |
Azithromycin (CP-62993)
|
Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections. |
-
J Cell Biochem, 2022, 10.1002/jcb.30213
-
Hum Cell, 2022, 10.1007/s13577-022-00671-y
-
Hum Cell, 2021, 34(6):1911-1918
|
|
S1884 |
Sparfloxacin
|
Sparfloxacin (AT-4140, CI-978, PD 131501) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity. |
|
|
S1915 |
Sulfamethoxazole
|
Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM. |
|
|
S1977 |
Sarafloxacin HCl
|
Sarafloxacin HCl (A-56620) is a hydrochloride salt form of sarafloxacin which is a quinolone antibiotic drug with IC50 of 0.96 μg/L. |
|
|
S1998 |
D-Cycloserine
|
D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis. |
|
|
S2048 |
Clindamycin Phosphate
|
Clindamycin Phosphate (NSC 618653) is a lincosamide antibiotic for Plasmodium falciparum with IC50 of 12 nM. |
|
|
S2052 |
Oxytetracycline Dihydrate
|
Oxytetracycline Dihydrate is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins. |
-
Front Microbiol, 2016, 7:1765
|
|
S2152 |
Sitafloxacin Hydrate
|
Sitafloxacin Hydrate (DU-6859a) is a new-generation, broad-spectrum oral fluoroquinolone antibiotic. |
-
Interact Cardiovasc Thorac Surg, 2018, 10.1093/icvts/ivy209
-
mSphere, 2018, 3(5)
|
|
S2159 |
Tebipenem Pivoxil
|
Tebipenem pivoxil (L-084, ME1211) is an oral carbapenem antibiotic, use to treat otolaryngologic and respiratory infections. |
|
|
S2315 |
Kanamycin sulfate
|
Kanamycin sulfate (Kanamycin monosulfate, Ophtalmokalixan) is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. |
-
Oncotarget, 2018, 9(40):26086-26095
|
|
S2385 |
Hordenine
|
Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties. |
|
|
S2506 |
Roxithromycin
|
Roxithromycin (Roxl-150) is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. |
-
Chemistry, 2020, 10.1002/chem.201905599
-
J Med Chem, 2018, 61(9):4189-4202
|
|
S2510 |
Spectinomycin 2HCl
|
Spectinomycin 2HCl (Actinospectacin) is a new parenteral antibiotic prepared from Streptomyces spectabilis. |
-
Cell Rep, 2020, 32(2):107897
|
|
S2514 |
Tobramycin
|
Tobramycin (NSC 180514) is an aminoglycoside antibiotic with an IC50 of 9.7 μM. |
-
Oncotarget, 2018, 9(40):26086-26095
|
|
S2530 |
7-Aminocephalosporanic acid
|
7-Aminocephalosporanic acid is used for synthesis of cephalosporin antibiotics and intermediates. |
|
|
S2539 |
Lomefloxacin HCl
|
Lomefloxacin HCl is a hydrochloride salt of lomefloxacin and is a fluoroquinolone antibiotic. |
-
Front Microbiol, 2020, 10:2936
|
|
S2543 |
Ceftiofur HCl
|
Ceftiofur HCl (U-67279A) is a cephalosporin antibiotic, used to treat both Gram-positive and Gram-negative bacteria infection. |
|
|
S2544 |
Cefprozil hydrate
|
Cefprozil hydrate is a semi-synthetic broad-spectrum cephalosporin antibiotic, used to treat certain infections caused by bacteria, such as bronchitis and infections of the ears, throat, sinuses, and skin. |
|
|
S2563 |
Oxacillin sodium monohydrate
|
Oxacillin sodium monohydrate (Methicillin) is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class. |
|
|
S2565 |
Amoxicillin Sodium
|
Amoxicillin Sodium (Clavulanate) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic. |
-
ChemMedChem, 2022, e202200043
-
PLoS Comput Biol, 2020, 16(12):e1008489
-
Toxicol Appl Pharmacol, 2015, 285(1):51-60
|
|
S2568 |
Neomycin sulfate
|
Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections. |
-
Mol Cell, 2020, 22 pii: S1097-2765(20)30231-8
|
|
S2574 |
Tetracycline HCl
|
Tetracycline HCl (NCI-c55561) is a hydrochloride salt of tetracycline that is a broad-spectrum polyketide antibiotic. |
-
PLoS Pathog, 2020, 16;16(3):e1008341
-
Antiviral Res, 2020, 185:104993
-
Sci Rep, 2018, 8(1):7653
|
|
S2583 |
Thiamphenicol
|
Thiamphenicol (Thiophenicol) is an antimicrobial antibiotic and a methyl-sulfonyl analogue of chloramphenicol. |
|
|
S3015 |
Amoxicillin
|
Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. |
-
ChemMedChem, 2022, e202200043
-
PLoS Comput Biol, 2020, 16(12):e1008489
-
Toxicol Appl Pharmacol, 2015, 285(1):51-60
|
|
S3055 |
Besifloxacin HCl
|
Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic. |
|
|
S3059 |
Enrofloxacin
|
Enrofloxacin (BAY-Vp2674, PD160788) is a fluoroquinolone antibiotic. |
|
|
S3105 |
Nadifloxacin
|
Nadifloxacin (OPC-7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. |
-
Pharmaceutics, 2021, 13(8)1289
|
|
S3122 |
Amikacin hydrate
|
Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. |
-
Molecules, 2019, 25(1)
|
|
S3129 |
Trimethoprim
|
Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. |
|
|
S3162 |
Tylosin tartrate
|
Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. |
|
|
S3170 |
Ampicillin sodium
|
Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family. |
-
Exp Ther Med, 2022, 23(3):216
-
Vet J, 2018, 234:24-26
|
|
S3179 |
Carbenicillin disodium
|
Carbenicillin (BRL-2064) is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity. |
|
|
S3193 |
Ticarcillin sodium
|
Ticarcillin (AB 2288, BRL 2288) is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. |
|
|
S3636 |
Cefadroxil hydrate
|
Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections. |
|
|
S3645 |
Kitasamycin
|
Kitasamycin (Leucomycin) is a macrolide antibiotic. It has antimicrobial activity against a wide spectrum of pathogens. |
|
|
S3650 |
Penicillin V potassium salt
|
Phenoxymethylpenicillin, also known as penicillin V, is an antibiotic useful for the treatment of a number of bacterial infections. It acts by inhibiting the biosynthesis of cell-wall peptidoglycan. |
|
|
S3672 |
Cefonicid sodium
|
Cefonicid sodium (Monocid) is a cephalosporin antibiotic. It interferes with cell wall biosynthesis in bacteria, leading to lysis of the infectious organism. |
|
|
S3708 |
Sulfachloropyridazine
|
Sulfachloropyridazine is an antibiotic used to treat a variety of bacterial infections. |
|
|
S3971 |
Fusidine
|
Fusidine (Fusidic Acid), isolated from Fusidium coccineum, is a steroidal antibiotic that inhibits protein synthesis. |
|
|
S4030 |
Gentamicin Sulfate
|
Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms. |
-
Universitätsmedizin Berlin, 2021, 10.17169/refubium-29871
-
Cell, 2020, S0092-8674(20)31394-5
|
|
S4052 |
Netilmicin Sulfate
|
Netilmicin Sulfate is a member of the aminoglycoside family of antibiotics. |
-
J Cancer Res Clin Oncol, 2019, 145(6):1495-1507
|
|
S4056 |
Retapamulin
|
Retapamulin (SB-275833) is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM. |
-
Pediatr Infect Dis J, 2021, 40(7):637-638
-
Hum Mol Genet, 2020, ddaa244
|
|
S4060 |
Erythromycin Ethylsuccinate
|
Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis. |
|
|
S4082 |
Spiramycin
|
Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic). |
-
Chemistry, 2020, 10.1002/chem.201905599
|
|
S4093 |
Bismuth Subcitrate Potassium
|
Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection. |
-
Cell Rep, 2022, 38(6):110359
-
J Clin Invest, 2020, 130(7):3901-3918
|
|
S4122 |
Tilmicosin
|
Tilmicosin (EL 870) is a macrolide antibiotic. |
|
|
S4148 |
Ampicillin Trihydrate
|
Ampicillin Trihydrate (NCI-C56086) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. |
-
Bone Joint Res, 2020, 16;9(4):152-161
|
|
S4150 |
Orbifloxacin
|
Orbifloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic. |
|
|
S4156 |
Chlortetracycline HCl (NSC 13252)
|
Chlortetracycline HCl (NSC 13252, 7-Chlorotetracycline, Aureomycin monohydrochloride) is the first identified tetracycline antibiotic. |
|
|
S4158 |
Ceftriaxone disodium salt hemi (heptahydrate)
|
Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic. |
-
J Neurochem, 2020, 155(4):370-389
-
J Neurochem, 2020, 155(4):370-389
|
|
S4160 |
Penicillin G Sodium
|
Penicillin G Sodium (Benzylpenicillin) is a β-lactam antibiotic produced by Penicillin spp. |
-
Cell Rep, 2015, 11(1):98-110
|
|
S4179 |
Mezlocillin Sodium
|
Mezlocillin sodium is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. |
|
|
S4183 |
Paromomycin Sulfate
|
Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA. |
|
|
S4213 |
Dirithromycin
|
Dirithromycin (LY-237216, ASE 136) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides. |
|
|
S4215 |
Ribostamycin Sulfate
|
Ribostamycin (Vistamycin) is an aminoglycoside antibiotic, containing a neutral sugar moiety, and is produced by Streptomyces ribosidificus. |
-
PLoS Pathog, 2020, 16;16(3):e1008341
-
Pathogens, 2019, 8(3)
|
|
S4222 |
Piperacillin Sodium
|
Piperacillin (CL227193) is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. |
-
Cancer Discov, 2020, CD-20-0160
-
Analytical Methods, 2018, 10.1039/C8AY00150B
|
|
S4226 |
Minocycline (CL 59806) HCl
|
Minocycline (CL 59806) HCl is the most lipid soluble and most active tetracycline antibiotic, binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis. |
-
Int J Mol Sci, 2022, 23(5)2793
-
Front Bioeng Biotechnol, 2022, 10:855755
-
Neuropharmacology, 2022, 207:108950
|
|
S4234 |
Capreomycin Sulfate
|
Capreomycin Sulfate is a cyclic peptide antibiotic and thought to inhibit protein synthesis by binding to the 70S ribosomal unit. |
-
Mol Cell Proteomics, 2019, 18(2):231-244
|
|
S4254 |
Apramycin Sulfate
|
Apramycin Sulfate (Ai3-29795) is an aminoglycoside antibiotic, which binds to the deep groove of the RNA. |
|
|
S4271 |
Isepamicin Sulphate
|
Isepamicin Sulphate (Isepamicine, Isepamycin, sch21420) is an aminoglycoside antibiotic, which inhibits bacterial protein synthesis by targeting the bacterial 30S ribosomal subunit.
|
|
|
S4279 |
Demeclocycline HCl
|
Demeclocycline HCl is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections.
|
-
J Biol Chem, 2020, 10.1074/jbc.RA119.011633.
-
Sci Rep, 2018, 8(1):7653
|
|
S4393 |
Cephapirin Sodium
|
Cephapirin Sodium (Cefapirin) is the sodium salt form of cephapirin, a semi-synthetic, first-generation cephalosporin antibiotic with bactericidal activity.Cephapirin Sodium is effective against gram-negative and gram-positive organisms. |
|
|
S4421 |
Josamycin
|
Josamycin (EN-141, Kitasamycin A3, Leucomycin A3, Turimycin A5) is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens. |
|
|
S4517 |
Cefotaxime sodium
|
Cefotaxime sodium salt is a third-generation cephalosporin antibiotic; broad-spectrum antibiotic with activity against numerous Gram-positive and Gram-negative bacteria. |
|
|
S4523 |
Dihydrostreptomycin sulfate
|
Dihydrostreptomycin sulfate is an aminoglycoside antibiotic, used to treat bacterial diseases in cattle, pigs and sheep. Dihydrostreptomycin is a derivative of streptomycin. |
|
|
S4536 |
Nitrofurantoin
|
Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis. |
|
|
S4540 |
Sisomicin sulfate
|
Sisomicin sulfate is an aminoglycoside antibiotic, isolated from the fermentation broth of a new species of the genus Micromonospora. |
|
|
S4585 |
Succinylsulfathiazole
|
Succinylsulfathiazole (Succinylsulphathiazole), a sulfonamide, is an antibiotic. |
|
|
S4594 |
Cephalothin sodium
|
Cephalothin (Cefalotin, Cephalotin) sodium is a semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. |
|
|
S4595 |
Cefazolin Sodium
|
Cefazolin Sodium (cefazoline, cephazolin, Ancef) is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. |
|
|
S4596 |
Cefixime
|
Cefixime (Cefixima, Cefiximum, Cephoral, Cefspan, FR-17027, FK-027, CL-284635) is an antibiotic useful for the treatment of a number of bacterial infections. It is a third generation cephalosporin. |
|
|
S4612 |
Dapson
|
Dapson (Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS), also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. |
|
|
S4641 |
Tedizolid Phosphate
|
Tedizolid (TR-701FA) is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid. |
-
Sci Transl Med, 2019, 11(516)
|
|
S4663 |
Fusidate Sodium
|
Fusidate Sodium (Fucidin, SQ-16360) is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections. |
|
|
S4671 |
Cefradine
|
Cefradine (Cephradine, Sefril, Anspor, Velosef) is a semi-synthetic cephalosporin antibiotic. |
|
|
S4720 |
Cefotaxime
|
Cefotaxime is a third-generation cephalosporin antibiotic and has broad spectrum activity against Gram positive and Gram negative bacteria. |
|
|
S4750 |
Sulfacetamide sodium salt hydrate
|
Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. |
|
|
S4812 |
Ceftizoxime
|
Ceftizoxime is a semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. It is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. |
|
|
S4813 |
Cefuroxime axetil
|
Cefuroxime axetil, a prodrug of the cephalosporin cefuroxime, is a second generation oral cephalosporin antibiotic with in vitro antibacterial activity against several gram-positive and gram-negative organisms. |
|
|
S4833 |
Cefoxitin sodium
|
Cefoxitin Sodium is the sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. |
|
|
S4847 |
Faropenem Sodium
|
Faropenem sodium is an orally active beta-lactam antibiotic that has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia. |
|
|
S4848 |
Dalbavancin
|
Dalbavancin (Zeven, BI 397, MDL 63397) is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci. |
|
|
S4850 |
Flucloxacillin sodium
|
Flucloxacillin sodium (Floxacillin sodium) is the sodium salt of flucloxacillin, a penicillin antibiotic used to treat bacterial infections. |
|
|
S4865 |
Cefetamet pivoxil hydrochloride
|
Cefetamet pivoxil hydrochloride is the hydrochloride salt form of cefetamet pivoxil, which is an oral third-generation cephalosporin antibiotic. |
|
|
S4869 |
Sulfamethoxazole sodium
|
Sulfamethoxazole sodium is an antibiotic used for bacterial infections. |
|
|
S4870 |
Cefodizime Sodium
|
Cefodizime Sodium, a third generation cephalosporin antibiotic, has broad-spectrum activity and is stable to most beta-lactamases. |
|
|
S4885 |
Taurolidine
|
Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities. |
|
|
S4978 |
Azathramycin
|
Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose. |
|
|
S4986 |
Latamoxef sodium
|
Latamoxef sodium (Moxalactam Disodium, FestamoxinLy, Shiomarin, Ly 127935, 6059 S) is an antibiotic and has anti-bacterial and anti-inflammation effects. |
|
|
S5035 |
6-Aminopenicillanic acid
|
6-Aminopenicillanic acid (6-APA) is the central component of penicillin β-lactam antibiotics which are generated by Penicillium. It is used as precursor for antibiotic compounds ampicillin and amoxicillin. |
|
|
S5041 |
Difloxacin hydrochloride
|
Difloxacin is a second-generation, synthetic fluoroquinolone antimicrobial antibiotic used in veterinary medicine. |
|
|
S5048 |
Fosfomycin Disodium
|
Fosfomycin (Phosphonemycin) is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis. |
|
|
S5051 |
Pipemidic acid
|
Pipemidic acid (Acido pipemidico) is a pyridopyrimidine antibiotic derivative of piromidic acid with activity against gram-negative and some gram-positive bacteria. |
-
Hum Mol Genet, 2020, ddaa244
|
|
S5070 |
Mupirocin calcium
|
Mupirocin Calcium (Pseudomonic acid A) is the calcium salt form of mupirocin, a natural crotonic acid derivative extracted from Pseudomonas fluorescens,which inhibits bacterial protein synthesis and is used as an antibiotic. |
|
|
S5108 |
Tylosin
|
Tylosin (Fradizine, Tylocine, Tylosine, Tylosin A) is a macrolide-class broad spectrum antibiotic that's used in veterinary medicine to treat felines, canines and livestock. |
|
|
S5159 |
Doxycycline
|
Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor. |
-
Mol Cancer, 2022, 21(1):43
-
Mol Cell, 2022, S1097-2765(22)00433-6
-
Theranostics, 2022, 12(7):3131-3149
|
|
S5206 |
Benzylpenicillin potassium
|
Benzylpenicillin potassium (Penicillin G potassium) is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. |
|
|
S5207 |
Cephalexin Monohydrate
|
Cephalexin is a semisynthetic cephalosporin antibiotic with antimicrobial activity. |
|
|
S5208 |
Ciprofloxacin hydrochloride hydrate
|
Ciprofloxacin Hydrochloride (Ciloxan, Ceprimax, Oftacilox) is the hydrochloride salt form of ciprofloxacin, which is an antibiotic used to treat a number of bacterial infections. |
|
|
S5227 |
Erythromycin thiocyanate
|
Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits and inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. |
|
|
S5268 |
Solithromycin
|
Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor. |
|
|
S5278 |
Tedizolid (TR-700)
|
Tedizolid is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria. |
|
|
S5290 |
Ormetoprim
|
Ormetoprim (OMP) is an antibiotic to prevent the spread of disease in freshwater aquaculture. |
|
|
S5294 |
Cephalotin acid
|
Cephalotin acid (Cephalothin, Cefalotin, Cephalothinum) is a cephalosporin antibiotic. |
|
|
S5295 |
Lincomycin Hydrochloride Monohydrate
|
Lincomycin hydrochloride monohydrate is a narrow-spectrum antibiotic used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections. |
|
|
S5296 |
Cephradine monohydrate
|
Cefradine is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. |
|
|
S5298 |
Amoxicillin trihydrate
|
Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. |
-
ChemMedChem, 2022, e202200043
-
PLoS Comput Biol, 2020, 16(12):e1008489
|
|
S5299 |
Tosufloxacin p-Toluenesulfonate Hydrate
|
Tosufloxacin (T-3262) is a fluoroquinolone antibiotic that is used to treat susceptible infections. |
|
|
S5328 |
Gamithromycin
|
Gamithromycin (ML-1709460) is a new macrolide antibiotic that is only registered for use in cattle to treat respiratory disorders such as bovine respiratory disease. |
-
Hum Cell, 2020, 10.1007/s13577-020-00420-z
|
|
S5330 |
Amikacin Sulfate Salt
|
Amikacin (BAY 41-6551) sulfate, a semisynthetic analog of kanamycin, is an aminoglycoside antibiotic which is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains. |
|
|
S5333 |
Sulbenicillin Sodium
|
Sulbenicillin Sodium (Sulfocillin, Sulfobenzylpenicillin) is the sodium salt of sulbenicillin, which is a penicillin antibiotic. |
|
|
S5350 |
Cefpodoxime proxetil
|
Cefpodoxime Proxetil is a third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. |
|
|
S5351 |
Cefmetazole sodium
|
Cefmetazole sodium is a semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. |
|
|
S5353 |
Cefpiramide sodium
|
Cefpiramide sodium (CPMS, SM-1652,wy-44635) is an anionic β-lactam antibiotic. It exhibits antibacterial activity against gram-positive and gram-negative bacteria, in particular, to Pseudomonas aeruginosa, which can result in achronic life-threatening infection in the lungs of cystic fibrosis patients. |
|
|
S5410 |
Chloramphenicol sodium succinate
|
Chloramphenicol Sodium Succinate is the sodium succinate salt form of chloramphenicol, a nitrobenzene derivate and broad-spectrum antibiotic with antibacterial activity. |
-
Oncotarget, 2018, 9(40):26086-26095
|
|
S5417 |
Spectinomycin dihydrochloride pentahydrate
|
Spectinomycin dihydrochloride pentahydrate (Trobicin) is a widely used antibiotic that inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome. |
|
|
S5420 |
Clindamycin alcoholate
|
Clindamycin alcoholate is a crystallizable compound of Clindamycin with alcohol. Clindamycin is a semisynthetic lincosamide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. |
|
|
S5421 |
Fluoroquinolonic Acid
|
Fluoroquinolonic Acid (Ciprofloxacin Impurity A, Q-Acid) is an antibiotic and antimicrobial agent. |
|
|
S5473 |
Pivmecillinam hydrochloride
|
Pivmecillinam is a β-lactam antibiotic and a prodrug of mecillinam. It has selective activity against Gram-negative bacteria and is used primarily in the treatment of lower urinary tract infections. |
|
|
S5487 |
Cefoperazone sodium
|
Cefoperazone Sodium is the sodium salt form of cefoperazone, which is a semi-synthetic, broad-spectrum, beta-lactamase resistant antibiotic with bactericidal activity. |
|
|
S5491 |
Lomefloxacin
|
Lomefloxacin is a fluoroquinolone antibiotic used to treat bacterial infections. |
|
|
S5515 |
Penicillin G Procaine
|
Procaine benzylpenicillin (Procaine benzylpenicillin), also known as Procaine benzylpenicillin, is an antibiotic useful for the treatment of a number of bacterial infections. |
|
|
S5531 |
Doripenem
|
Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens. |
-
Biomed Chromatogr, 2017, 31(5)
|
|
S5533 |
Tobramycin sulfate
|
Tobramycin sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. |
-
Oncotarget, 2018, 9(40):26086-26095
|
|
S5535 |
Moxifloxacin
|
Moxifloxacin is an antibiotic used to treat a number of bacterial infections, active against Mycobacterium tuberculosis in vitro. |
-
Transl Vis Sci Technol, 2018, 7(2):11
-
J Pharmacol Toxicol Methods, 2017, 90:39-47
-
Circ Arrhythm Electrophysiol, 2016, 9(4):e003655
|
|
S5560 |
Midecamycin
|
Midecamycin (Espinomycin A, Medecamycin A1, Platenomycin B1, Rubimycin, Turimycin P3) is a naturally occuring macrolide antibiotic that acts by inhibiting bacterial protein synthesis. |
|
|
S5573 |
Tilmicosin phosphate
|
Tilmicosin phosphate is a macrolide antibiotic that is used to treat cattle for pathogens that cause Bovine Respiratory Disease. |
|
|
S5601 |
Balofloxacin Dihydrate
|
Balofloxacin Dihydrate is an orally active fluoroquinolone antibiotic. |
|
|
S5637 |
Cefotiam Hexetil Hydrochloride
|
Cefotiam Hexetil Hydrochloride is the hydrochloride salt of cefotiam hexetil. Cefotiam is a semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. |
|
|
S5644 |
Ceftriaxone Sodium
|
Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. |
|
|
S5657 |
Ertapenem sodium
|
Ertapenem Sodium (MK826) is the sodium salt of ertapenem, a long-acting, broad-spectrum antibiotic of β-lactam subclass. |
|
|
S5719 |
Ceftizoxime sodium
|
Ceftizoxime sodium is a semisynthetic cephalosporin antibiotic that is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. |
|
|
S5736 |
Benzathine penicilline
|
Benzathine penicilline (Benzathine penicillin G) is an antibiotic useful for the treatment of a number of bacterial infections. |
|
|
S5744 |
Spiramycin I
|
Spiramycin I (Foromacidin A) is a main component of spiramycin, which is a macrolide antimicrobial agent with broad spectrum antibiotic activity. |
|
|
S5784 |
Vancomycin
|
Vancomycin is an antibiotic used to treat serious bacterial infections. It works by stopping the growth of bacteria. |
-
Gut Microbes, 2020, 12(1):1-20
-
Oncotarget, 2018, 9(40):26086-26095
|
|
S5859 |
Sancycline
|
Sancycline (Bonomycin, Norcycline, GS 2147) is a semi-synthetic tetracycline antibiotic. |
|
|
S5936 |
Cefazolin
|
Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. |
|
|
S5941 |
Besifloxacin
|
Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis. |
|
|
S5951 |
Cefoxitin
|
Cefoxitin is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. |
|
|
S5968 |
Kasugamycin hydrochloride hydrate
|
Kasugamycin (Ksg) hydrochloride hydrate, an antibiotic which binds both the 30S and 70S ribosome, specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs. |
|
|
S6068 |
Doxycycline monohydrate
|
Doxycycline is a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. |
-
Mol Cancer, 2022, 21(1):43
-
Theranostics, 2022, 12(7):3131-3149
-
EMBO Rep, 2022, e52984
|
|
S6423 |
Tildipirosin
|
Tildipirosin is a 16-membered ring, tribasic and semi-synthetic macrolide antibiotic. |
-
Nat Cell Biol, 2017, 19(10):1274-1285
|
|
S6562 |
KKL-35
|
KKL-35 inhibits the trans-translation tagging reaction with an IC50 of 0.9 µM. It has broad-spectrum antibiotic activity. |
|
|
S6582 |
Ozenoxacin
|
Ozenoxacin is a quinolone antibiotic used for the treatment of impetigo. |
|
|
S8871 |
Omadacycline tosylate
|
Omadacycline tosylate is a first-in-class aminomethylcycline antibiotic, demonstrating antimicrobial activity in vitro against a range of Gram-positive and Gram-negative aerobes and some anaerobic bacteria. |
|
|