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Tylosin tartrate Antibiotics for Mammalian Cell Culture inhibitor

Name: Tylosin tartrate
Brand: Selleck Chemicals
SKU: S3162
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3162

Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.

Chemical Structure

Molecular Weight: 1066.19

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Quality Control

Batch: Purity: 99.52%

99.52

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Solubility

In vitro
Batch:

DMSO : 300 mg/mL (281.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 300 mg/mL

Water : 200 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	1066.19	Formula	C₄₆H₇₇NO₁₇.C₄H₆O₆	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	74610-55-2	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.C(C(C(=O)O)O)(C(=O)O)O

Mechanism of Action

In vitro	Tylosin tartrate (25 mg/L) significantly inhibits methane production relative to unamended controls, thus indicating that this compound at concentrations commonly found in swine lagoons can negatively impact anaerobic metabolism. Its disappearance follows a biphasic pattern, where rapid initial loss is followed by a slow removal phase. The 90% disappearance times for tylosin, relomycin (tylosin D), and desmycosin (tylosin B) in anaerobically incubated slurries are 30 to 130 hours, and aerating the slurries reduced the 90% disappearance times to between 12 and 26 hours. This chemical is stable for at least one month when stored in Milli-Q water at pH 5.7 to 6.7 at 22 ℃.
In vivo	Tylosin increases splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels from whole splenocyte cultures in chickens. Tylosin also increases antitumor activity of splenocytes in chickens. This compound (50 mg/kg) administered orally twice daily for 10 days, beginning 14 days after intranasal infection, significantly reduces the incidence and severity of macroscopical pneumonic lung lesions in neonatal piglets. After this chemical administered intravenously (i.v.) at 10 mg/kg in camels, serum tylosin concentrations in the water-deprived camels are significantly higher, rate of drug elimination is slower, the volume of distribution is significantly smaller, and total body clearance is significantly slower than in the normal camels. On the other hand, serum tylosin concentrations are lower in the water deprived camels and the mean absorption time is significantly shorter in camels treat with this compound (20 mg/kg i.m.).
References	[1] https://pubmed.ncbi.nlm.nih.gov/15839550/ [2] https://pubmed.ncbi.nlm.nih.gov/15765935/ [3] https://pubmed.ncbi.nlm.nih.gov/9733118/ [4] https://pubmed.ncbi.nlm.nih.gov/7134653/ [5] https://pubmed.ncbi.nlm.nih.gov/8583543/

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