For research use only.
CAS No. 74610-55-2
Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.
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|Description||Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.|
Tylosin tartrate (25 mg/L) significantly inhibits methane production relative to unamended controls, thus indicating that Tylosin tartrate at concentrations commonly found in swine lagoons can negatively impact anaerobic metabolism.  Tylosin disappearance follows a biphasic pattern, where rapid initial loss is followed by a slow removal phase. The 90% disappearance times for tylosin, relomycin (tylosin D), and desmycosin (tylosin B) in anaerobically incubated slurries are 30 to 130 hours, and aerating the slurries reduced the 90% disappearance times to between 12 and 26 hours. Tylosin tartrate is stable for at least one month when stored in Milli-Q water at pH 5.7 to 6.7 at 22 ℃. 
|In vivo||Tylosin increases splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels from whole splenocyte cultures in chickens. Tylosin also increases antitumor activity of splenocytes in chickens.  Tylosin tartrate (50 mg/kg) administered orally twice daily for 10 days, beginning 14 days after intranasal infection, significantly reduces the incidence and severity of macroscopical pneumonic lung lesions in neonatal piglets.  After tylosin tartrate administered intravenously (i.v.) at 10 mg/kg in camels, serum tylosin concentrations in the water-deprived camels are significantly higher, rate of drug elimination is slower, the volume of distribution is significantly smaller, and total body clearance is significantly slower than in the normal camels. On the other hand, serum tylosin concentrations are lower in the water deprived camels and the mean absorption time is significantly shorter in camels treat with tylosin tartrate (20 mg/kg i.m.). |
-  Loftin KA, et al. Environ Toxicol Chem, 2005, 24(4), 782-788.
-  Kolz AC, et al. Water Environ Res, 2005, 77(1), 49-56.
-  Baba T, et al. Poult Sci, 1998, 77(9), 1306-13011.
|In vitro||DMSO||300 mg/mL (281.37 mM)|
|Ethanol||300 mg/mL (281.37 mM)|
|Water||200 mg/mL (187.58 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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