Home Microbiology Antibiotics chemical - Topoisomerase chemical Gemifloxacin mesylate

research use only

Gemifloxacin mesylate Antibiotics chemical

Cat.No.E0706

Gemifloxacin mesylate (SB265805 mesylate; LB20304 mesylate) is a novel fluoronaphthyridone with a broad spectrum of antimicrobial activity and enhances activity against gram-positive aerobes.
Gemifloxacin mesylate Antibiotics chemical Chemical Structure

Chemical Structure

Molecular Weight: 485.49

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: E070601 DMSO]97 mg/mL]false]Water]97 mg/mL]false]Ethanol]Insoluble]false Purity: 99.9%
99.9

Chemical Information, Storage & Stability

Molecular Weight 485.49 Formula

C18H20FN5O4.CH4O3S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 210353-53-0 Download SDF Storage of Stock Solutions

Synonyms SB265805 mesylate; LB20304 mesylate Smiles CO\N=C\1CN(CC1CN)C2=C(F)C=C3C(=O)C(=CN(C4CC4)C3=N2)C(O)=O.C[S](O)(=O)=O

Solubility

In vitro
Batch:

DMSO : 97 mg/mL (199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 97 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vivo

Gemifloxacin targets both DNA gyrase (preferred target) and topoisomerase IV (secondary target) – enzymes critical for DNA replication and organism survival – against clinical isolates of S. pneumoniae.[2]
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.