Dirithromycin

Catalog No.S4213 Synonyms: LY-237216, ASE 136

Dirithromycin Chemical Structure

Molecular Weight(MW): 835.07

Dirithromycin is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.

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Choose Selective Anti-infection Inhibitors

Biological Activity

Description Dirithromycin is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.
In vitro

At therapeutic concentrations, dirithromycin enhances IL1 beta production by LPS-stimulated cells, with +37 per cent and +28 per cent at 1 microgram/ml respectively. At supratherapeutic concentrations, it inhibits IL1 beta production through protein kinase C inhibition, with inhibitory concentrations 50 per cent of 378 micrograms/ml for dirithromycin and 234 micrograms/ml for spiramycin.

Protocol

Solubility (25°C)

In vitro Ethanol 100 mg/mL (119.75 mM)
DMSO 11 mg/mL (13.17 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 835.07
Formula

C42H78N2O14

CAS No. 62013-04-1
Storage powder
in solvent
Synonyms LY-237216, ASE 136

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02237768 Unknown status Healthy Pharmaceutical Research Unit Jordan|Abdi Ibrahim Ilac San. ve Tic A.S. December 2014 Phase 1
NCT02237768 Unknown status Healthy Pharmaceutical Research Unit Jordan|Abdi Ibrahim Ilac San. ve Tic A.S. December 2014 Phase 1
NCT02237807 Unknown status Healthy Pharmaceutical Research Unit Jordan|Abdi Ibrahim Ilac San. ve Tic A.S. September 2014 Phase 1
NCT02237807 Unknown status Healthy Pharmaceutical Research Unit Jordan|Abdi Ibrahim Ilac San. ve Tic A.S. September 2014 Phase 1
NCT02185833 Completed Healthy Pharmaceutical Research Unit Jordan|Abdi Ibrahim Ilac San. ve Tic A.S. June 2014 Phase 1
NCT02185846 Completed Healthy Pharmaceutical Research Unit Jordan|Abdi Ibrahim Ilac San. ve Tic A.S. June 2014 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID