Piperacillin Sodium

Catalog No.S4222 Synonyms: CL227193

For research use only.

Piperacillin (CL227193) is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.

Piperacillin Sodium Chemical Structure

CAS No. 59703-84-3

Selleck's Piperacillin Sodium has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Piperacillin (CL227193) is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.
Targets
beta-lactamase [1]
In vitro

Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Piperacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Piperacillin results from the inhibition of cell wall synthesis and is mediated through Piperacillin binding to penicillin binding proteins (PBPs). By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. Piperacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 539.54
Formula

C23H27N5O7S.Na

CAS No. 59703-84-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05464680 Not yet recruiting Other: blood sample and bronchoalveolar lavage ARDS|SARS-CoV 2 Pneumonia Assistance Publique Hopitaux De Marseille September 1 2022 Not Applicable
NCT04276480 Not yet recruiting Drug: Piperacillin-tazobactam Enterobacteriaceae Infections University Hospital Bordeaux July 2021 Not Applicable
NCT04775238 Recruiting Other: Silver nanoparticles|Other: Copper nanoparticles Nosocomial Infections Sohag University February 27 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

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