Piperacillin Sodium

For research use only.

Catalog No.S4222 Synonyms: CL227193

2 publications

Piperacillin Sodium Chemical Structure

CAS No. 59703-84-3

Piperacillin (CL227193) is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.

Selleck's Piperacillin Sodium has been cited by 2 publications

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Biological Activity

Description Piperacillin (CL227193) is a semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections.
Targets
beta-lactamase [1]
In vitro

Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Piperacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Piperacillin results from the inhibition of cell wall synthesis and is mediated through Piperacillin binding to penicillin binding proteins (PBPs). By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. Piperacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. [1]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (185.34 mM)
Water 100 mg/mL (185.34 mM)
Ethanol '100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 539.54
Formula

C23H27N5O7S.Na

CAS No. 59703-84-3
Storage powder
in solvent
Synonyms CL227193
Smiles CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04276480 Not yet recruiting Drug: Piperacillin-tazobactam Enterobacteriaceae Infections University Hospital Bordeaux July 2021 Not Applicable
NCT04775238 Recruiting Other: Silver nanoparticles|Other: Copper nanoparticles Nosocomial Infections Sohag University February 27 2021 Not Applicable
NCT04776486 Recruiting Drug: Iohexol Augmented Renal Clearance|Critically Ill Assistance Publique - Hôpitaux de Paris September 3 2020 Not Applicable
NCT04700202 Recruiting Other: Observational Ventilator-associated Pneumonia|Hospital-acquired Pneumonia Methodist Health System June 30 2020 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID