Catalog No.S4122 Synonyms: EL 870
Molecular Weight(MW): 869.13
Tilmicosin is a macrolide antibiotic.
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|Description||Tilmicosin is a macrolide antibiotic.|
Tilmicosin inhibits growth of Pasteurella multocida, Pasteurella haemolytica, Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Streptococcus suis, Actinomyces pyogenes and certain other bacteria at levels of 6.25 μg/mL or less. In general, the MICs for Gram-negative enteric bacteria have been greater than 50 μg/mL.  Tilmicosin causes decreases in cardiac SOD and GPX activities. 
|In vivo||After a subcutaneous injection, tilmicosin is eliminated more slowly from serum and milk, with t1/2 beta S of 29.3 and 41.4 hours, respectively. The apparent volume of distribution of tilmicosin is more than 1 L/kg. The peak serum tilmicosin concentration is 1.56 μg/mL. 6.39 hours after a subcutaneous injection of 10 mg/kg. Tilmicosin is extensively secreted into milk, reaching a maximum concentration of 11.6 μg/mL and having a large AUCmilk/AUCserum ratio of approximately 12:1. Tilmicosin is detectable in milk for 11 days after a single subcutaneous dose.|
|In vitro||DMSO||100 mg/mL (115.05 mM)|
|Water||8 mg/mL (9.2 mM)|
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