For research use only.

Catalog No.S4122 Synonyms: EL 870

Tilmicosin Chemical Structure

CAS No. 108050-54-0

Tilmicosin (EL 870) is a macrolide antibiotic.

Purity & Quality Control

Choose Selective Antibiotics Inhibitors

Biological Activity

Description Tilmicosin (EL 870) is a macrolide antibiotic.
In vitro

Tilmicosin inhibits growth of Pasteurella multocida, Pasteurella haemolytica, Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Streptococcus suis, Actinomyces pyogenes and certain other bacteria at levels of 6.25 μg/mL or less. In general, the MICs for Gram-negative enteric bacteria have been greater than 50 μg/mL. [1] Tilmicosin causes decreases in cardiac SOD and GPX activities. [3]

In vivo After a subcutaneous injection, tilmicosin is eliminated more slowly from serum and milk, with t1/2 beta S of 29.3 and 41.4 hours, respectively. The apparent volume of distribution of tilmicosin is more than 1 L/kg. The peak serum tilmicosin concentration is 1.56 μg/mL. 6.39 hours after a subcutaneous injection of 10 mg/kg. Tilmicosin is extensively secreted into milk, reaching a maximum concentration of 11.6 μg/mL and having a large AUCmilk/AUCserum ratio of approximately 12:1. Tilmicosin is detectable in milk for 11 days after a single subcutaneous dose.[2]


Solubility (25°C)

In vitro DMSO 100 mg/mL (115.05 mM)
Water 8 mg/mL (9.2 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 869.13


CAS No. 108050-54-0
Storage powder
in solvent
Synonyms EL 870

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID