Penicillin G Sodium

Catalog No.S4160 Synonyms: Benzylpenicillin Sodium

For research use only.

Penicillin G Sodium (Benzylpenicillin) is a β-lactam antibiotic produced by Penicillin spp.

Penicillin G Sodium Chemical Structure

CAS No. 69-57-8

Selleck's Penicillin G Sodium has been cited by 1 Publication

Purity & Quality Control

Choose Selective Antibiotics for Mammalian Cell Culture Inhibitors

Biological Activity

Description Penicillin G Sodium (Benzylpenicillin) is a β-lactam antibiotic produced by Penicillin spp.
In vitro

Benzylpenicillin is also commonly known as penicillin G. Benzylpenicillin exhibits activity mainly against Gram-positive organisms. Some Gram-negative organisms such as Neisseria gonorrhoeae and Neisseria meningitidis are also reported to be susceptible to Penicillin G.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 356.37


CAS No. 69-57-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04647331 Recruiting -- Infective Endocarditis Uppsala University June 1 2021 --
NCT03612557 Completed Drug: penicillin G benzathine Healthy Pfizer August 20 2018 Phase 1
NCT00789217 Completed Procedure: Immediate skin test Penicillin Allergy Chulalongkorn University|Mahidol University December 2008 Not Applicable
NCT01944358 Completed -- Serologic Response of Syphilis|Early Syphilis|High Risk Behavior National Taiwan University Hospital|Far Eastern Memorial Hospital|Taichung Veterans General Hospital|National Cheng-Kung University Hospital|Chang Gung Memorial Hospital|Chi Mei Medical Hospital|Kaohsiung Medical University Chung-Ho Memorial Hospital|E-DA Hospital January 2007 --

(data from, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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