Ribostamycin Sulfate

Catalog No.S4215 Synonyms: Vistamycin Sulfate

For research use only.

Ribostamycin (Vistamycin) is an aminoglycoside antibiotic, containing a neutral sugar moiety, and is produced by Streptomyces ribosidificus.

Ribostamycin Sulfate Chemical Structure

CAS No. 53797-35-6

Selleck's Ribostamycin Sulfate has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Ribostamycin (Vistamycin) is an aminoglycoside antibiotic, containing a neutral sugar moiety, and is produced by Streptomyces ribosidificus.
In vitro

Ribostamycin inhibits the chaperone activity of protein disulfide isomerase (PDI), but it does not inhibit the isomerase activity, a 100:1 molar ratio of ribostamycin to PDI is almost sufficient to completely inhibit the chaperone activity of PDI. Ribostamycin binds to purified bovine PDI with KD of 0.319 mM. Ribostamycin is especially effective against the gentamicin-resistant bacterium Klebsiella pneumoniae, which possesses aminoglycoside-modifying enzymes. [1] Ribostamycin exhibits antimicrobial activity against B. burgdorferi isolates with MIC of 18.7 mg/L. [2] Ribostamycin (16 mcg/mL) inhibits 100% of the P. stagnora strains and 95% of the P. wickerhamii strains, while Ribostamycin (16 mcg/mL) inhibits 100% of the P. zopfii strains. [3]

In vivo Ribostamycin (400 mg/kg/day) shows the weakest ototoxicity against the cochlea and vestibular organs in guinea pigs. Ribostamycin (400 mg/kg/day), causing the weakest ototoxicity, shows a low drug concentration in the inner ear fluid of of guinea pigs. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 552.55
Formula

C17H34N4O10.H2SO4

CAS No. 53797-35-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)O)O)O)N.OS(=O)(=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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