Ribostamycin Sulfate

Catalog No.S4215 Synonyms: Vistamycin Sulfate

For research use only.

Ribostamycin (Vistamycin) is an aminoglycoside antibiotic, containing a neutral sugar moiety, and is produced by Streptomyces ribosidificus.

Ribostamycin Sulfate Chemical Structure

CAS No. 53797-35-6

Selleck's Ribostamycin Sulfate has been cited by 2 Publications

Purity & Quality Control

Choose Selective Selection Antibiotics for Transfected Cell Inhibitors

Biological Activity

Description Ribostamycin (Vistamycin) is an aminoglycoside antibiotic, containing a neutral sugar moiety, and is produced by Streptomyces ribosidificus.
In vitro

Ribostamycin inhibits the chaperone activity of protein disulfide isomerase (PDI), but it does not inhibit the isomerase activity, a 100:1 molar ratio of ribostamycin to PDI is almost sufficient to completely inhibit the chaperone activity of PDI. Ribostamycin binds to purified bovine PDI with KD of 0.319 mM. Ribostamycin is especially effective against the gentamicin-resistant bacterium Klebsiella pneumoniae, which possesses aminoglycoside-modifying enzymes. [1] Ribostamycin exhibits antimicrobial activity against B. burgdorferi isolates with MIC of 18.7 mg/L. [2] Ribostamycin (16 mcg/mL) inhibits 100% of the P. stagnora strains and 95% of the P. wickerhamii strains, while Ribostamycin (16 mcg/mL) inhibits 100% of the P. zopfii strains. [3]

In vivo Ribostamycin (400 mg/kg/day) shows the weakest ototoxicity against the cochlea and vestibular organs in guinea pigs. Ribostamycin (400 mg/kg/day), causing the weakest ototoxicity, shows a low drug concentration in the inner ear fluid of of guinea pigs. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 552.55


CAS No. 53797-35-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)O)O)O)N.OS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Ribostamycin Sulfate | Ribostamycin Sulfate ic50 | Ribostamycin Sulfate price | Ribostamycin Sulfate cost | Ribostamycin Sulfate solubility dmso | Ribostamycin Sulfate purchase | Ribostamycin Sulfate manufacturer | Ribostamycin Sulfate research buy | Ribostamycin Sulfate order | Ribostamycin Sulfate mouse | Ribostamycin Sulfate chemical structure | Ribostamycin Sulfate mw | Ribostamycin Sulfate molecular weight | Ribostamycin Sulfate datasheet | Ribostamycin Sulfate supplier | Ribostamycin Sulfate in vitro | Ribostamycin Sulfate cell line | Ribostamycin Sulfate concentration | Ribostamycin Sulfate nmr