Home Microbiology Selection Antibiotics for Transfected Cell inhibitor Ribostamycin Sulfate

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Ribostamycin Sulfate Selection Antibiotics for Transfected Cell inhibitor

Cat.No.S4215

Ribostamycin Sulfate(Vistamycin Sulfate,Landamycine) is an aminoglycoside antibiotic, containing a neutral sugar moiety, and is produced by Streptomyces ribosidificus.
Ribostamycin Sulfate Selection Antibiotics for Transfected Cell inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 552.55

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Quality Control

Batch: Purity: 98.28%
98.28

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 552.55 Formula

C17H34N4O10.H2SO4

 Storage (From the date of receipt)
CAS No. 53797-35-6 Download SDF Storage of Stock Solutions

Synonyms Vistamycin Sulfate,Landamycine Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)O)O)O)N.OS(=O)(=O)O

Mechanism of Action

In vitro

Ribostamycin inhibits the chaperone activity of protein disulfide isomerase (PDI), but it does not inhibit the isomerase activity, a 100:1 molar ratio of ribostamycin to PDI is almost sufficient to completely inhibit the chaperone activity of PDI. Ribostamycin binds to purified bovine PDI with KD of 0.319 mM. Ribostamycin is especially effective against the gentamicin-resistant bacterium Klebsiella pneumoniae, which possesses aminoglycoside-modifying enzymes. Ribostamycin exhibits antimicrobial activity against B. burgdorferi isolates with MIC of 18.7 mg/L. Ribostamycin (16 mcg/mL) inhibits 100% of the P. stagnora strains and 95% of the P. wickerhamii strains, while Ribostamycin (16 mcg/mL) inhibits 100% of the P. zopfii strains.

In vivo

Ribostamycin (400 mg/kg/day) shows the weakest ototoxicity against the cochlea and vestibular organs in guinea pigs. Ribostamycin (400 mg/kg/day), causing the weakest ototoxicity, shows a low drug concentration in the inner ear fluid of of guinea pigs.

References
  • [4] https://pubmed.ncbi.nlm.nih.gov/2311443/

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