D-Cycloserine

For research use only.

Catalog No.S1998 Synonyms: RO-1-9213

D-Cycloserine Chemical Structure

CAS No. 68-41-7

D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.

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Biological Activity

Description D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.
In vivo D-cycloserine (DCS) facilitates extinction of conditioned freezing to the light CS when no drug pre-exposure has occurred, but pre-exposure to DCS just prior to conditioning disrupted the facilitation of extinction effect in mice. [1] D-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. DCS also facilitates retention in 'senescence-accelerated mice' in which impairment of learning andmemory increases with age. [2] D-cycloserine (DCS) exhibits facilitated extinction of fear but are able to reacquire fear of that conditioned stimulus (CS) in a similar manner as saline-treated control rats. DCS-treated rats exhibits generalized extinction (i.e., they are less fearful of a non-extinguished CS) in comparison to controls. [3] D-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learningtasks in rats. DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity. [4] D-cycloserine injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhances extinction but does not influence fear-potentiated startle in rats that does not receive extinction training. [5]

Protocol

Solubility (25°C)

In vitro Water 20 mg/mL (195.9 mM)
DMSO Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 102.09
Formula

C3H6N2O2

CAS No. 68-41-7
Storage powder
in solvent
Synonyms RO-1-9213
Smiles C1C(C(=O)NO1)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01399866 Completed Drug: D-cycloserine|Drug: Placebo Smoking Cessation Massachusetts General Hospital May 2011 Phase 3
NCT00964041 Withdrawn Drug: D-cycloserine|Drug: Placebo Schizophrenia Massachusetts General Hospital|National Institute of Mental Health (NIMH) July 2009 Phase 4
NCT01062932 Completed Drug: Cycloserine|Drug: Placebo Nicotine Addiction Baylor College of Medicine|National Institute on Drug Abuse (NIDA) May 2009 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID