For research use only.
Catalog No.S1998 Synonyms: RO-1-9213
CAS No. 68-41-7
D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.
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|Description||D-cycloserine (RO-1-9213) is an analog of the amino acid D-alanine, used as an antibiotic in the treatment of tuberculosis.|
|In vivo||D-cycloserine (DCS) facilitates extinction of conditioned freezing to the light CS when no drug pre-exposure has occurred, but pre-exposure to DCS just prior to conditioning disrupted the facilitation of extinction effect in mice.  D-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. DCS also facilitates retention in 'senescence-accelerated mice' in which impairment of learning andmemory increases with age.  D-cycloserine (DCS) exhibits facilitated extinction of fear but are able to reacquire fear of that conditioned stimulus (CS) in a similar manner as saline-treated control rats. DCS-treated rats exhibits generalized extinction (i.e., they are less fearful of a non-extinguished CS) in comparison to controls.  D-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learningtasks in rats. DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity.  D-cycloserine injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhances extinction but does not influence fear-potentiated startle in rats that does not receive extinction training. |
-  Parnas AS, et al. Neurobiol Learn Mem,?005, 83(3), 224-231.
-  Flood JF, et al. Eur J Pharmacol,?992, 221(2-3), 249-254.
-  Ledgerwood L, et al. Biol Psychiatry,?005, 57(8), 841-847.
|In vitro||Water||20 mg/mL (195.9 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01399866||Completed||Drug: D-cycloserine|Drug: Placebo||Smoking Cessation||Massachusetts General Hospital||May 2011||Phase 3|
|NCT00964041||Withdrawn||Drug: D-cycloserine|Drug: Placebo||Schizophrenia||Massachusetts General Hospital|National Institute of Mental Health (NIMH)||July 2009||Phase 4|
|NCT01062932||Completed||Drug: Cycloserine|Drug: Placebo||Nicotine Addiction||Baylor College of Medicine|National Institute on Drug Abuse (NIDA)||May 2009||Phase 1|
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