Taurolidine

For research use only.

Catalog No.S4885 Synonyms: Taurolin, Tauroline, Tauroflex

Taurolidine Chemical Structure

CAS No. 19388-87-5

Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.
In vitro

Taurolidine inhibits the growth of a rat metastatic colorectal tumor cell line in vitro[1]. Taurolidine possesses antineoplastic activity. The antiproliferative IC50 of taurolidine is in the 10-50 μM range, approximately 100-fold lower that that required for its antibiotic effects. Exposure to taurolidine induces apoptosis in SKOV-3 and PA-1 human tumor cells but apparently not in NIH-3T3 fibroblasts[2]. Taurolidine causes significant in vitro growth inhibition and cytotoxicity of human MM cells, which appears to be due, at least in part, to apoptosis[3].

In vivo In BD IX rats that underwent laparotomy, intraperitoneal instillation of DHD/K12/TRb tumor cells, local/intraperitoneal administration of taurolidine results in a marked decrease in tumor burden compared with control animals[1]. The i.p. administration of taurolidine effectively inhibits the development and growth of ovarian tumors when therapy is initiated on the day of tumor cell injection[2]. i.p. taurolidine inhibits adherence of colon tumor cells injected into the peritoneal cavity of rats[3].

Protocol

Cell Research:[1]
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  • Cell lines: a rat metastatic colorectal tumor cell line (DHD/K12/TRb)
  • Concentrations: 5, 10, 15, 25 mg/ml
  • Incubation Time: 14 h
  • Method: DHD/K12/TRb cells (1×105 cells/ml) are cultured in 24-well plates and incubated for 6 hours at 37°C in humidified 5% CO2 conditions to allow the cells to adhere. Culture medium is then removed and fresh culture medium alone (control) or culture medium with 5, 10, 15, and 25 mg/ml of Taurolidine is added. Cells are then incubated at 37°C in humidified 5% CO2 conditions for a further 14 hours followed by addition of 10 ml of BrdU labeling solution.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Adult male syngenic BD IX rats, aged 8-10 weeks
  • Dosages: 100 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 56 mg/mL (196.93 mM)
Ethanol '-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 284.36
Formula

C7H16N4O4S2

CAS No. 19388-87-5
Storage powder
in solvent
Synonyms Taurolin, Tauroline, Tauroflex
Smiles C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02279121 Completed Device: Taurolock|Drug: saline solution Catheter-Related Infections Centre Hospitalier Régional Metz-Thionville|centre régional de pharmacovigilance de Nancy|Theradial November 2014 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID