Taurolidine

Catalog No.S4885 Synonyms: Taurolin, Tauroline, Tauroflex

For research use only.

Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.

Taurolidine Chemical Structure

CAS No. 19388-87-5

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.
In vitro

Taurolidine inhibits the growth of a rat metastatic colorectal tumor cell line in vitro[1]. Taurolidine possesses antineoplastic activity. The antiproliferative IC50 of taurolidine is in the 10-50 μM range, approximately 100-fold lower that that required for its antibiotic effects. Exposure to taurolidine induces apoptosis in SKOV-3 and PA-1 human tumor cells but apparently not in NIH-3T3 fibroblasts[2]. Taurolidine causes significant in vitro growth inhibition and cytotoxicity of human MM cells, which appears to be due, at least in part, to apoptosis[3].

In vivo In BD IX rats that underwent laparotomy, intraperitoneal instillation of DHD/K12/TRb tumor cells, local/intraperitoneal administration of taurolidine results in a marked decrease in tumor burden compared with control animals[1]. The i.p. administration of taurolidine effectively inhibits the development and growth of ovarian tumors when therapy is initiated on the day of tumor cell injection[2]. i.p. taurolidine inhibits adherence of colon tumor cells injected into the peritoneal cavity of rats[3].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: a rat metastatic colorectal tumor cell line (DHD/K12/TRb)
  • Concentrations: 5, 10, 15, 25 mg/ml
  • Incubation Time: 14 h
  • Method: DHD/K12/TRb cells (1×105 cells/ml) are cultured in 24-well plates and incubated for 6 hours at 37°C in humidified 5% CO2 conditions to allow the cells to adhere. Culture medium is then removed and fresh culture medium alone (control) or culture medium with 5, 10, 15, and 25 mg/ml of Taurolidine is added. Cells are then incubated at 37°C in humidified 5% CO2 conditions for a further 14 hours followed by addition of 10 ml of BrdU labeling solution.
Animal Research:[1]
  • Animal Models: Adult male syngenic BD IX rats, aged 8-10 weeks
  • Dosages: 100 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 284.36
Formula

C7H16N4O4S2

CAS No. 19388-87-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02279121 Completed Device: Taurolock|Drug: saline solution Catheter-Related Infections Centre Hospitalier Régional Metz-Thionville|centre régional de pharmacovigilance de Nancy|Theradial November 2014 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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