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Taurolidine Bacterial chemical

Cat.No.S4885

Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.
Taurolidine Bacterial chemical Chemical Structure

Chemical Structure

Molecular Weight: 284.36

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Quality Control

Batch: S488501 DMSO]56 mg/mL]false]]]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 284.36 Formula

C7H16N4O4S2

 Storage (From the date of receipt)
CAS No. 19388-87-5 -- Storage of Stock Solutions

Synonyms Taurolin, Tauroline, Tauroflex Smiles C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2

Solubility

In vitro
Batch:

DMSO : 56 mg/mL (196.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro
Taurolidine inhibits the growth of a rat metastatic colorectal tumor cell line in vitro[1]. This compound possesses antineoplastic activity. The antiproliferative IC50 of this chemical is in the 10-50 μM range, approximately 100-fold lower that that required for its antibiotic effects. Exposure to this agent induces apoptosis in SKOV-3 and PA-1 human tumor cells but apparently not in NIH-3T3 fibroblasts[2]. It causes significant in vitro growth inhibition and cytotoxicity of human MM cells, which appears to be due, at least in part, to apoptosis[3].
In vivo
In BD IX rats that underwent laparotomy, intraperitoneal instillation of DHD/K12/TRb tumor cells, local/intraperitoneal administration of taurolidine results in a marked decrease in tumor burden compared with control animals[1]. The i.p. administration of this compound effectively inhibits the development and growth of ovarian tumors when therapy is initiated on the day of tumor cell injection[2]. i.p. taurolidine inhibits adherence of colon tumor cells injected into the peritoneal cavity of rats[3].
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02279121 Completed
Catheter-Related Infections
Centre Hospitalier Régional Metz-Thionville|centre régional de pharmacovigilance de Nancy|Theradial
 November 2014 Not Applicable

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