For research use only.
Catalog No.S4885 Synonyms: Taurolin, Tauroline, Tauroflex
CAS No. 19388-87-5
Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.
Purity & Quality Control
Choose Selective Bacterial Inhibitors
|Description||Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.|
Taurolidine inhibits the growth of a rat metastatic colorectal tumor cell line in vitro. Taurolidine possesses antineoplastic activity. The antiproliferative IC50 of taurolidine is in the 10-50 μM range, approximately 100-fold lower that that required for its antibiotic effects. Exposure to taurolidine induces apoptosis in SKOV-3 and PA-1 human tumor cells but apparently not in NIH-3T3 fibroblasts. Taurolidine causes significant in vitro growth inhibition and cytotoxicity of human MM cells, which appears to be due, at least in part, to apoptosis.
|In vivo||In BD IX rats that underwent laparotomy, intraperitoneal instillation of DHD/K12/TRb tumor cells, local/intraperitoneal administration of taurolidine results in a marked decrease in tumor burden compared with control animals. The i.p. administration of taurolidine effectively inhibits the development and growth of ovarian tumors when therapy is initiated on the day of tumor cell injection. i.p. taurolidine inhibits adherence of colon tumor cells injected into the peritoneal cavity of rats.|
|In vitro||DMSO||56 mg/mL (196.93 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Taurolin, Tauroline, Tauroflex|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02279121||Completed||Device: Taurolock|Drug: saline solution||Catheter-Related Infections||Centre Hospitalier Régional Metz-Thionville|centre régional de pharmacovigilance de Nancy|Theradial||November 2014||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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