Trimethoprim

For research use only.

Catalog No.S3129 Synonyms: BW 56-72, NIH 204, NSC-106568

Trimethoprim Chemical Structure

CAS No. 738-70-5

Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
In vitro

Trimethoprim acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. The Inhibition starves the bacteria of nucleotides necessary for DNA replication causing, in certain circumstances, cell lethality due to thymineless death.

Protocol

Solubility (25°C)

In vitro DMSO 58 mg/mL (199.77 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 290.32
Formula

C14H18N4O3

CAS No. 738-70-5
Storage powder
in solvent
Synonyms BW 56-72, NIH 204, NSC-106568
Smiles COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03424525 Recruiting Drug: 11C-Trimethoprim Bacterial Infections University of Pennsylvania February 1 2018 Phase 1
NCT02475876 Completed Drug: Clindamycin|Drug: trimethoprim-sulfamethoxazole Bacterial Infections Michael Cohen-Wolkowiez|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University November 2015 Phase 1
NCT01167452 Completed Drug: Sulfamethoxazole/trimethoprim Obesity|Pharmacokinetics|MRSA|Tuberculosis|PCP Texas Tech University Health Sciences Center|National Center for Research Resources (NCRR)|University of Texas Southwestern Medical Center July 2010 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID