Trimethoprim

Catalog No.S3129 Synonyms: BW 56-72, NIH 204, NSC-106568

For research use only.

Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.

Trimethoprim Chemical Structure

CAS No. 738-70-5

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
In vitro

Trimethoprim acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. The Inhibition starves the bacteria of nucleotides necessary for DNA replication causing, in certain circumstances, cell lethality due to thymineless death.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 290.32
Formula

C14H18N4O3

CAS No. 738-70-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03424525 Recruiting Drug: 11C-Trimethoprim Bacterial Infections University of Pennsylvania February 1 2018 Phase 1
NCT02475876 Completed Drug: Clindamycin|Drug: trimethoprim-sulfamethoxazole Bacterial Infections Michael Cohen-Wolkowiez|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Duke University November 2015 Phase 1
NCT01167452 Completed Drug: Sulfamethoxazole/trimethoprim Obesity|Pharmacokinetics|MRSA|Tuberculosis|PCP Texas Tech University Health Sciences Center|National Center for Research Resources (NCRR)|University of Texas Southwestern Medical Center July 2010 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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