Home Microbiology Antineoplastic and Immunosuppressive Antibiotics inhibitor - Antibiotics chemical Tobramycin

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Tobramycin Antineoplastic and Immunosuppressive Antibiotics inhibitor

Cat.No.S2514

Tobramycin (NSC 180514,Deoxykanamycin B, Nebramycin Factor 6) is an aminoglycoside antibiotic with an IC50 of 9.7 μM.
Tobramycin Antineoplastic and Immunosuppressive Antibiotics inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 467.52369

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Chemical Information, Storage & Stability

Molecular Weight 467.52369 Formula

C18H37N5O9

 Storage (From the date of receipt)
CAS No. 32986-56-4 Download SDF Storage of Stock Solutions

Synonyms NSC 180514,Deoxykanamycin B, Nebramycin Factor 6 Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N

Solubility

In vitro
Batch:

Water : 94 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06016088 Recruiting
Cystic Fibrosis Lung|Respiratory Infections Recurrent Chronic|Pseudomonas Aeruginosa
Respirion Pharmaceuticals Pty Ltd
 April 1 2024 Phase 1|Phase 2
NCT05169229 Recruiting
Arthroplasty Replacement Hip|Osteoarthritis Hip|Antibiotic Resistant Infection|Prosthetic Joint Infection
University Hospital Linkoeping|Region Östergötland|The Swedish Research Council
 April 1 2022 Phase 2|Phase 3
NCT04964947 Recruiting
Wound Infection|Fractures Open|Surgical Site Infection
Massachusetts General Hospital|United States Department of Defense
 January 10 2022 Phase 3
NCT04297631 Completed
Antibotics in Cementless Knees
Washington University School of Medicine
 February 14 2020 Phase 4
NCT03904836 Completed
Renal Dialysis|Renal Failure Chronic
Maisonneuve-Rosemont Hospital
 January 31 2019 Phase 1

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