Enrofloxacin

Catalog No.S3059 Synonyms: BAY-Vp2674, PD160788

For research use only.

Enrofloxacin (BAY-Vp2674, PD160788) is a fluoroquinolone antibiotic.

Enrofloxacin Chemical Structure

CAS No. 93106-60-6

Purity & Quality Control

Choose Selective Antibiotics Inhibitors

Biological Activity

Description Enrofloxacin (BAY-Vp2674, PD160788) is a fluoroquinolone antibiotic.
In vitro

Enrofloxacin is a synthetic chemotherapeutic agent from the class of the fluoroquinolone carboxylic acid derivatives. It has antibacterial activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Enrofloxacin is believed to act by inhibiting bacterial DNA gyrase (a type-II topoisomerase), thereby preventing DNA supercoiling and DNA synthesis.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 3 mg/mL warmed
(8.34 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 359.39
Formula

C19H22FN3O3

CAS No. 93106-60-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03575312 Completed Drug: Enrofloxacin Healthy Fraunhofer-Institute of Toxicology and Experimental Medicine|Federal Institute for Occupational Safety and Health (BAuA)/Germany) April 27 2018 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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