Dalbavancin

For research use only.

Catalog No.S4848 Synonyms: Zeven, BI 397, MDL 63397

Dalbavancin Chemical Structure

CAS No. 171500-79-1

Dalbavancin (Zeven, BI 397, MDL 63397) is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci.

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Biological Activity

Description Dalbavancin (Zeven, BI 397, MDL 63397) is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci.
In vitro

Dalbavancin's mechanism of action involves the formation of a complex with the C-terminal d-alanyl-d-alanine of growing peptidoglycan chains, thereby inhibiting bacterial cell wall biosynthesis. In addition, dalbavancin appears to have the unique ability to dimerise and anchor its lipophilic side chain in the bacterial membranes. Dalbavancin possesses more potent in vitro bactericidal activity than vancomycin or teicoplanin against many resistant Gram-positive organisms[1].

In vivo Dalbavancin has a half-life of 170-210 h in human. It exhibits linear, dose-dependent pharmacokinetics in healthy adults, following the administration of single intravenous doses of dalbavancin 140-1120 mg. Total protein binding of dalbavancin is concentration independent, reversible and estimated to be 93%. Animal studies regarding tissue distribution have demonstrated tissue concentrations reaching maximal levels within 24 h, with the highest concentrations in the liver and kidneys[1].

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (55.04 mM)
Water 100 mg/mL (55.04 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1816.69
Formula

C88H100Cl2N10O28

CAS No. 171500-79-1
Storage powder
in solvent
Synonyms Zeven, BI 397, MDL 63397
Smiles CNC1C(=O)NC2CC3=CC=C(OC4=C(OC5OC(C(O)C(O)C5NC(=O)CCCCCCCCC(C)C)C(O)=O)C6=CC(=C4)C(NC(=O)C(NC2=O)C7=CC(=CC(=C7Cl)O)OC8=CC=C1C=C8O)C(=O)NC9C(=O)NC(C(O)C%10=CC(=C(O6)C=C%10)Cl)C(=O)NC(C(=O)NCCCN(C)C)C%11

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID