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Difloxacin hydrochloride

Name: Difloxacin hydrochloride
Brand: Selleck Chemicals
SKU: S5041
Rating: 5 (1 reviews)

Catalog No.S5041 Purity: 99.28%

Difloxacin is a second-generation, synthetic fluoroquinolone antimicrobial antibiotic used in veterinary medicine.

Difloxacin hydrochloride Chemical Structure

CAS: 91296-86-5

Purity & Quality Control

Batch: Purity: 99.28%

99.28

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Biological Activity

Description	Difloxacin is a second-generation, synthetic fluoroquinolone antimicrobial antibiotic used in veterinary medicine.

In Vivo
In vivo	Difloxacin has almost 100% bioavailability and good penetration into tissues and cells. It is 46-52% bound to plasma proteins in human patients. Difloxacin is extensively metabolized by glucuronidation and secreted into bile^[1].
Animal Research	Animal Models	Female beagles aged 11-13 months
	Dosages	5 mg/kg
	Administration	oral

References

[1] Frazier DL, et al. J Vet Pharmacol Ther. 2000, 23(5):293-302.

Chemical Information & Solubility

Molecular Weight	435.85	Formula	C₂₁H₁₉F₂N₃O₃.HCl
CAS No.	91296-86-5	SDF	--
Smiles	CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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