Teicoplanin

Catalog No.S1399 Synonyms: Teichomycin

Teicoplanin Chemical Structure

Molecular Weight(MW): 1709.39

Teicoplanin is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.

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Biological Activity

Description Teicoplanin is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.
In vitro

Teicoplanin is associated with small increases in the GI colonization by C. albicans. [1] The inhibitory action of Teicoplanin on proteoglycan polymerization but not on nucleic acid and protein synthesis indicates that the effect in the wall is due to the accumulation at this level of proteoglycan soluble precursors continuously produced by the cell. [2] Teicoplanin, at a concentration of 1 mg/mL, causes rapid lysis of exponential phase cells of Streptococcus faecalis. [3] Teicoplanin inhibits peptidoglycan synthesis in intact cells and in cell-free systems. Teicoplanin-induced lysis is dependent on the growth phase of B. pumilus at the time of addition of the antibiotic. Teicoplanin induces lysis after a longer lag phase with slowly growing Strep. jhecalis CCM 1875 and lysis is not very extensive. [4]

In vivo Teicoplanin therapy increases the survival rate whereas G-CSF therapy does not in comparison to other groups in neutropenic mice. Teicoplanin and G-CSF combination therapy improves survival rate when compared with groups II, III, IV. [5]

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (58.5 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1709.39
Formula

C77H77N9O31Cl2·R

CAS No. 61036-62-2
Storage powder
in solvent
Synonyms Teichomycin

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03909698 Recruiting Other: Blood and urine sampling Kidney Failure Chronic|Antibiotics|Hemodialysis University Hospital Ghent|University Ghent September 15 2016 --
NCT03229135 Completed Device: other antibacterial agents,breathing machine Pneumonia Gram-Positive Bacterial People''s Hospital of Zhengzhou University February 1 2015 --
NCT03177369 Completed -- Teicoplanin-based Antimicrobial Therapy|Staphylococcus Aureus|Bone and Joint Infection Hospices Civils de Lyon January 2015 --
NCT01324804 Unknown status -- Coronary Heart Disease|Surgical Wound Infection Medical University of Vienna November 2010 --
NCT00754273 Completed Other: etest susceptability testing Methicillin-resistant Staphylococcal Aureus Pneumonia University of Kentucky|Pfizer September 2008 --
NCT00719056 Completed Drug: Teicoplanin|Drug: β-lactams or ciprofloxacin Total Hip and Knee Arthroplasties University of Athens|KAT Hospital of Athens August 2004 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID