Catalog No.S1399 Synonyms: Teichomycin
Molecular Weight(MW): 1709.39
Teicoplanin is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.
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|Description||Teicoplanin is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.|
Teicoplanin is associated with small increases in the GI colonization by C. albicans.  The inhibitory action of Teicoplanin on proteoglycan polymerization but not on nucleic acid and protein synthesis indicates that the effect in the wall is due to the accumulation at this level of proteoglycan soluble precursors continuously produced by the cell.  Teicoplanin, at a concentration of 1 mg/mL, causes rapid lysis of exponential phase cells of Streptococcus faecalis.  Teicoplanin inhibits peptidoglycan synthesis in intact cells and in cell-free systems. Teicoplanin-induced lysis is dependent on the growth phase of B. pumilus at the time of addition of the antibiotic. Teicoplanin induces lysis after a longer lag phase with slowly growing Strep. jhecalis CCM 1875 and lysis is not very extensive. 
|In vivo||Teicoplanin therapy increases the survival rate whereas G-CSF therapy does not in comparison to other groups in neutropenic mice. Teicoplanin and G-CSF combination therapy improves survival rate when compared with groups II, III, IV. |
-  Samonis G, et al. Med Mycol,?006, 44(2), 193-196.
-  Filice G, et al. Microbiologica,?990, 13(3), 231-237.
-  Cheng JK, et al. J Pharmacol Sci, 2006, 100(5), 471-486.
|In vitro||Water||100 mg/mL (58.5 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03909698||Recruiting||Other: Blood and urine sampling||Kidney Failure Chronic|Antibiotics|Hemodialysis||University Hospital Ghent|University Ghent||September 15 2016||--|
|NCT03229135||Completed||Device: other antibacterial agents，breathing machine||Pneumonia Gram-Positive Bacterial||People''s Hospital of Zhengzhou University||February 1 2015||--|
|NCT03177369||Completed||--||Teicoplanin-based Antimicrobial Therapy|Staphylococcus Aureus|Bone and Joint Infection||Hospices Civils de Lyon||January 2015||--|
|NCT01324804||Unknown status||--||Coronary Heart Disease|Surgical Wound Infection||Medical University of Vienna||November 2010||--|
|NCT00754273||Completed||Other: etest susceptability testing||Methicillin-resistant Staphylococcal Aureus Pneumonia||University of Kentucky|Pfizer||September 2008||--|
|NCT00719056||Completed||Drug: Teicoplanin|Drug: β-lactams or ciprofloxacin||Total Hip and Knee Arthroplasties||University of Athens|KAT Hospital of Athens||August 2004||Phase 4|
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