For research use only.
Catalog No.S1399 Synonyms: Teichomycin
CAS No. 61036-62-2
Teicoplanin (Teichomycin) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.
Selleck's Teicoplanin has been cited by 2 publications
Purity & Quality Control
Choose Selective Bacterial Inhibitors
|Description||Teicoplanin (Teichomycin) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.|
Teicoplanin is associated with small increases in the GI colonization by C. albicans.  The inhibitory action of Teicoplanin on proteoglycan polymerization but not on nucleic acid and protein synthesis indicates that the effect in the wall is due to the accumulation at this level of proteoglycan soluble precursors continuously produced by the cell.  Teicoplanin, at a concentration of 1 mg/mL, causes rapid lysis of exponential phase cells of Streptococcus faecalis.  Teicoplanin inhibits peptidoglycan synthesis in intact cells and in cell-free systems. Teicoplanin-induced lysis is dependent on the growth phase of B. pumilus at the time of addition of the antibiotic. Teicoplanin induces lysis after a longer lag phase with slowly growing Strep. jhecalis CCM 1875 and lysis is not very extensive. 
|In vivo||Teicoplanin therapy increases the survival rate whereas G-CSF therapy does not in comparison to other groups in neutropenic mice. Teicoplanin and G-CSF combination therapy improves survival rate when compared with groups II, III, IV. |
-  Samonis G, et al. Med Mycol,?006, 44(2), 193-196.
-  Filice G, et al. Microbiologica,?990, 13(3), 231-237.
-  Cheng JK, et al. J Pharmacol Sci, 2006, 100(5), 471-486.
|In vitro||Water||100 mg/mL (58.5 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03909698||Recruiting||Other: Blood and urine sampling||Kidney Failure Chronic|Antibiotics|Hemodialysis||University Hospital Ghent|University Ghent||September 15 2016||--|
|NCT03229135||Completed||Device: other antibacterial agents，breathing machine||Pneumonia Gram-Positive Bacterial||People''s Hospital of Zhengzhou University||February 1 2015||--|
|NCT03177369||Completed||--||Teicoplanin-based Antimicrobial Therapy|Staphylococcus Aureus|Bone and Joint Infection||Hospices Civils de Lyon||January 2015||--|
|NCT01324804||Unknown status||--||Coronary Heart Disease|Surgical Wound Infection||Medical University of Vienna||November 2010||--|
|NCT00754273||Completed||Other: etest susceptability testing||Methicillin-resistant Staphylococcal Aureus Pneumonia||University of Kentucky|Pfizer||September 2008||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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