For research use only.
CAS No. 1263-89-4
Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.
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|Description||Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.|
Paromomycin is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes.  In vitro analysis on the sensitivity of amastigotes in a murine macrophage model showed that L. major and L. tropica isolates (ED50s in the range of 1 to 5 μM) are more sensitive than L. braziliensis (ED50, <12 μM) and L. mexicana (ED50, 39 μM) isolates. L. donovani shows intermediate sensitivity (ED50, 6 to 18 μM), except for one Indian strain, DD8, which had an ED50 of >150 μM. 
|In vivo||In both experimental models and clinical cases of CL, lesions caused by L. major treated with paromomycin ointment resolved faster and more completely than lesions caused by L. amazonensis and L. panamensis. |
|In vitro||Water||100 mg/mL (140.11 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03399955||Recruiting||Drug: Paromomycin|Drug: Ambisome|Drug: Miltefosine||PKDL - Post-Kala-Azar Dermal Leishmanioid||Drugs for Neglected Diseases||May 9 2018||Phase 2|
|NCT00216346||Completed||Drug: Paromomycin sulfate|Drug: Amphotericin B||Visceral Leishmaniasis||PATH|World Health Organization||June 2003||Phase 3|
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