Paromomycin Sulfate

For research use only.

Catalog No.S4183

Paromomycin Sulfate Chemical Structure

CAS No. 1263-89-4

Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.

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Biological Activity

Description Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA.
16S ribosomal RNA [1]
In vitro

Paromomycin is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. [1] In vitro analysis on the sensitivity of amastigotes in a murine macrophage model showed that L. major and L. tropica isolates (ED50s in the range of 1 to 5 μM) are more sensitive than L. braziliensis (ED50, <12 μM) and L. mexicana (ED50, 39 μM) isolates. L. donovani shows intermediate sensitivity (ED50, 6 to 18 μM), except for one Indian strain, DD8, which had an ED50 of >150 μM. [2]

In vivo In both experimental models and clinical cases of CL, lesions caused by L. major treated with paromomycin ointment resolved faster and more completely than lesions caused by L. amazonensis and L. panamensis. [2]


Solubility (25°C)

In vitro Water 100 mg/mL (140.11 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 713.71


CAS No. 1263-89-4
Storage powder
in solvent
Synonyms N/A
Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03399955 Recruiting Drug: Paromomycin|Drug: Ambisome|Drug: Miltefosine PKDL - Post-Kala-Azar Dermal Leishmanioid Drugs for Neglected Diseases May 9 2018 Phase 2
NCT00216346 Completed Drug: Paromomycin sulfate|Drug: Amphotericin B Visceral Leishmaniasis PATH|World Health Organization June 2003 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID