Gentamicin Sulfate

Catalog No.S4030 Synonyms: NSC-82261, SCH9724

For research use only.

Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.

Gentamicin Sulfate Chemical Structure

CAS No. 1405-41-0

Selleck's Gentamicin Sulfate has been cited by 2 Publications

Purity & Quality Control

Choose Selective Selection Antibiotics for Transfected Cell Inhibitors

Biological Activity

Description Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.
In vitro

Gentamycin Sulfate is a complex of three different closely related aminoglycoside sulfates, Gentamicins c1, c1a and c2, obtained from Micromonospora purpurea and related species. [1] They are broad-spectrum antibiotics, but may cause ear and kidney damage. Gentamycin Sulfate is reported to have activity against gram-negative bacteria, Pseudomonas aeruginosa, gram-positive Staphylococcus aureus and some mycoplasmas. Reported to have low toxicity to mammalian cells and viruses at certain concentrations, useful for long-term tissue culture studies with viruses. [2] Gentamicin acts by binding to the 30S subunit of the bacterial ribosome leading to inhibition of protein synthesis and death in susceptible bacteria. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Water 100 mg/mL
DMSO Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight
Formula

H2SO4.xUnspecified

CAS No. 1405-41-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN.CNC(C)C.CNC1C(O)C(OCC1(C)O)OC2C(N)CC(N)C(OC3OC(CCC3N)[R])C2O.CC(C)N.O[S](O)(=O)=O

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04775238 Recruiting Other: Silver nanoparticles|Other: Copper nanoparticles Nosocomial Infections Sohag University February 27 2021 Not Applicable
NCT04644627 Recruiting Drug: Gentamicin Sulfate Epidermolysis Bullosa Oslo University Hospital December 1 2020 Phase 1|Phase 2
NCT04505748 Completed Device: Self-transfusion device Arthroplasty Complications|Total Knee Arthroplasty University Hospital Alexandroupolis|Democritus University of Thrace January 1 2020 Not Applicable
NCT03845790 Recruiting Other: Blood and microdialysis samples Surgical Site Infection Poitiers University Hospital May 26 2019 Phase 1
NCT03632109 Terminated Drug: gentamicin 360mg IM Pharyngeal Gonococcal Infection University of Washington|National Institute of Allergy and Infectious Diseases (NIAID) September 17 2018 Phase 2|Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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