Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Gentamicin Sulfate

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Gentamicin Sulfate DNase I Inhibitor

Cat.No.S4030

Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.Gentamicin Sulfate can be used to induce animal models of Renal Failure.
Gentamicin Sulfate DNA/RNA Synthesis inhibitor Chemical Structure

Chemical Structure

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Quality Control

Batch: Purity: 99.77%
99.77

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight Formula

H2SO4.xUnspecified

 Storage (From the date of receipt)
CAS No. 1405-41-0 Download SDF Storage of Stock Solutions

Synonyms NSC-82261, SCH9724 Smiles CCN.CNC(C)C.CNC1C(O)C(OCC1(C)O)OC2C(N)CC(N)C(OC3OC(CCC3N)[R])C2O.CC(C)N.O[S](O)(=O)=O

Mechanism of Action

In vitro
Gentamycin Sulfate is a complex of three different closely related aminoglycoside sulfates, Gentamicins c1, c1a and c2, obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. Gentamycin Sulfate is reported to have activity against gram-negative bacteria, Pseudomonas aeruginosa, gram-positive Staphylococcus aureus and some mycoplasmas. Reported to have low toxicity to mammalian cells and viruses at certain concentrations, useful for long-term tissue culture studies with viruses. Gentamicin acts by binding to the 30S subunit of the bacterial ribosome leading to inhibition of protein synthesis and death in susceptible bacteria.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06387147 Not yet recruiting
Acute Mesenteric Ischemia
Assistance Publique - Hôpitaux de Paris
 September 1 2024 Phase 3
NCT06362447 Not yet recruiting
Ichthyosis
University Hospital Toulouse
 April 23 2024 Phase 2
NCT05593601 Recruiting
Colonization Asymptomatic
Mahidol University
 November 24 2022 Phase 4
NCT05503147 Recruiting
Malnutrition|Anorexia|Cannabis|Aging|Emergency Service Hospital|Renal Function|Pharmacokinetics
Ove Andersen|University Hospital Bispebjerg and Frederiksberg|North Denmark Regional Hospital|University of Copenhagen|Region Hovedstadens Apotek|Glostrup University Hospital Copenhagen|Hvidovre University Hospital
 March 24 2022 Phase 1
NCT05251584 Unknown status
Peritoneal Dialysis-related Infection
Phramongkutklao College of Medicine and Hospital|Silpakorn University
 December 1 2021 Not Applicable

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