Gentamicin Sulfate

Synonyms: NSC-82261, SCH9724

Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.

Gentamicin Sulfate Chemical Structure

Gentamicin Sulfate Chemical Structure

CAS: 1405-41-0

Selleck's Gentamicin Sulfate has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.77%
99.77

Gentamicin Sulfate Related Products

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Biological Activity

Description Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.
In vitro
In vitro Gentamycin Sulfate is a complex of three different closely related aminoglycoside sulfates, Gentamicins c1, c1a and c2, obtained from Micromonospora purpurea and related species. [1] They are broad-spectrum antibiotics, but may cause ear and kidney damage. Gentamycin Sulfate is reported to have activity against gram-negative bacteria, Pseudomonas aeruginosa, gram-positive Staphylococcus aureus and some mycoplasmas. Reported to have low toxicity to mammalian cells and viruses at certain concentrations, useful for long-term tissue culture studies with viruses. [2] Gentamicin acts by binding to the 30S subunit of the bacterial ribosome leading to inhibition of protein synthesis and death in susceptible bacteria. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05593601 Recruiting
Colonization Asymptomatic
Mahidol University
November 24 2022 Phase 4
NCT05503147 Recruiting
Malnutrition|Anorexia|Cannabis|Aging|Emergency Service Hospital|Renal Function|Pharmacokinetics
Ove Andersen|University Hospital Bispebjerg and Frederiksberg|North Denmark Regional Hospital|University of Copenhagen|Region Hovedstadens Apotek|Glostrup University Hospital Copenhagen|Hvidovre University Hospital
March 24 2022 Phase 1
NCT05251584 Recruiting
Peritoneal Dialysis-related Infection
Phramongkutklao College of Medicine and Hospital|Silpakorn University
December 1 2021 Not Applicable
NCT04775238 Unknown status
Nosocomial Infections
Sohag University
February 27 2021 Not Applicable
NCT04644627 Completed
Epidermolysis Bullosa
Oslo University Hospital
December 1 2020 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight Formula

H2SO4.xUnspecified

CAS No. 1405-41-0 SDF Download Gentamicin Sulfate SDF
Smiles CCN.CNC(C)C.CNC1C(O)C(OCC1(C)O)OC2C(N)CC(N)C(OC3OC(CCC3N)[R])C2O.CC(C)N.O[S](O)(=O)=O
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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