Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Gentamicin Sulfate

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Gentamicin Sulfate DNase I Inhibitor

Cat.No.S4030

Gentamycin Sulfate (NSC-82261, SCH9724) is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms.Gentamicin Sulfate can be used to induce animal models of Renal Failure.
Gentamicin Sulfate DNA/RNA Synthesis inhibitor Chemical Structure

Chemical Structure

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Quality Control

Batch: Purity: 99.77%
99.77

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
Batch:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight Formula

H2SO4.xUnspecified

 Storage (From the date of receipt)
CAS No. 1405-41-0 Download SDF Storage of Stock Solutions

Synonyms NSC-82261, SCH9724 SMILES CCN.CNC(C)C.CNC1C(O)C(OCC1(C)O)OC2C(N)CC(N)C(OC3OC(CCC3N)[R])C2O.CC(C)N.O[S](O)(=O)=O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

In vitro
Gentamycin Sulfate is a complex of three different closely related aminoglycoside sulfates, Gentamicins c1, c1a and c2, obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. Gentamycin Sulfate is reported to have activity against gram-negative bacteria, Pseudomonas aeruginosa, gram-positive Staphylococcus aureus and some mycoplasmas. Reported to have low toxicity to mammalian cells and viruses at certain concentrations, useful for long-term tissue culture studies with viruses. Gentamicin acts by binding to the 30S subunit of the bacterial ribosome leading to inhibition of protein synthesis and death in susceptible bacteria.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2023-08-04)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05977400 NOT_YET_RECRUITING
Premature Birth; Antibiotics; Neurodevelopment
Sharp HealthCare
 2024-04 PHASE3
NCT07752849 RECRUITING
Cleft Palate; Unilateral Cleft Palate; Bilateral Cleft Palate; Complete Cleft Palat; Incompelet Cleft Palate
Al-Thawra Modern General Hospital
 2026-08-01
NCT06712641 RECRUITING
Sepsis
University Hospital, Akershus
 2026-04-23 PHASE4
NCT04876131 RECRUITING
Complicated Urinary Tract Infection; Infection; Pediatric Infectious Disease
Murdoch Childrens Research Institute
 2022-05-30 PHASE4
NCT05157126 RECRUITING
Fracture Open Tibia
University of California, San Francisco
 2022-09-01 PHASE4
NCT06814223 RECRUITING
Infection Catheter-Related
Western Galilee Hospital-Nahariya
 2024-10-28 PHASE4

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