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The role of DNA-dependent protein kinase in dendritic cells in house dust mite-induced asthma

 

DNA-dependent protein kinase (DNA-PK) plays a key role in the mechanism of cellular repair of double-stranded DNA breaks (DSB), which induced by ionizing radiation, or reactive oxygen species (ROS). Besides, DNA-PK also mediates V(D)J and immunoglobulin class switch recombination, and innate immune and pro-inflammatory responses. Mishra et al. demonstrated the immune role of DNA-PK in response to house dust mite (HDM) antigen in dendritic cells (DCs). The article was published in Nature Communications.

 

DCs are the primary antigen-presenting cells in allergic asthma induced by HDM antigen. In this study, researchers found HDM promotes DNA-PK phosphorylation in DCs, indicating an increase of DNA-PK activation. This process depends on ROS signaling pathway. Furthermore, DNA-PK is also involved in effective antigen presentation by DCs, as well as adaptive Th1-mediated immune responses to HDM antigen. In addition, the manifestations of mite-induced airway disease can be attenuated by antigen priming and pharmacological inhibition of DNA-PK. The findings revealed the connection between DNA-PK in DCs and allergic sensitization in response to HDM antigen, indicating that DNA-PK is a potential therapeutic target for HDM-induced asthma.

 

Reference:
Nat Commun. 2015 Feb 18;6:6224.

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