COMPOUND LIBRARY

INTRODUCTION OF COMPOUND LIBRARY:
A pool of various compounds in a position where all these compounds can be evaluated because of the high merit of their scientific storeroom is known as a compound library. Hence compound libraries are collections of various compounds. In these libraries storage, maintenance and placing is done in a scientific way. The evolution of different new technologies in managing and designing a chemical library led to some of remarkable drug discoveries, as these libraries provide a positive procedure for research [1]. The selection criteria for biologically active and relevant compounds and chemicals includes a huge set of synthesizable chemicals, it is an important and crucial part of research and usually needs the guidance of experts in the relevant field. These experts formulate schemes and protocols which make the selection faster and efficient than a practical chemical library. The state of the art methods which include both fragment based and structure based process of designing library are supported by the latest tools based on practical software and this ensure the successful accomplishment of compound library design.
 

SCHEMING A COMPOUND LIBRARY:
Although the designing and maintenance of a chemical library is formidable task, the careful description of chemicals or compounds and associated achievement advices from the experts compose it easier to get proper results. Against multiple diseases the novel technologies are present to help in new and effective drug discoveries by high throughput screening of these libraries. A compound library is a resource of suitable and systematically rich database that have the most relevant information about its constituents. All this information is mostly based on the compound’s chemical structure, the pure preparation and detailed knowledge of their chemical, pharmacological and physical properties [2].

SCREENING OF COMPOUND LIBRARY:
The biggest application of a compound library is due to the facility of efficient and detailed screening during a high throughput assay. The screening of a full library immensely helps in finding an appropriate drug against a specific disease. Normally a large library is further portioned into smaller libraries. The partition is based on either pharmacological compounds or structures similarity in order to generate rapid results during screening. The fact is based on such an idea like phosphatases or kinases would be jointly in a group, and so various compounds which are derivative of a parent compound. To screen a therapeutic agent, as a substitute of screening the complete library its smaller groups or sub parts are screened which increases the chances of right target in shorter time and cost. However the process of screening is again re-confirmed by screening again the same compound for desired condition [3]. Once a chemical is recognized that goes for further pre-clinical studies based on the through studies done before and on the basis of in vivo and in vitro studies that compound also undergo clinical trials [4].  The compound library screening process has been very systematic due to the latest software technologies of science, which helps in detecting the right compound for the desired purpose [5].

REFERENCES:
1. Zhou, J., Chemical Library Design. Methods in Molecular Biology. Vol. 685. 2011: Humana Press.
2. Schneider P, e.a., Self-Organizing Maps in Drug Discovery: Compound Library Design, Scaffold-Hopping, Repurposing Current Medicinal Chemistry, 2009.
3. Su GH, e.a., A Novel Histone Deacetylase Inhibitor Identified by High-Throughput Transcriptional Screening of a Compound Library. Cancer Res, 2000.
4. Huggins DJ, e.a., Rational Methods for the Selection of Diverse Screening Compounds. ACS Chem. Biol., 2011.
5. Gaillard Y, e.a., Use of high-performance liquid chromatography with photodiode-array UV detection for the creation of a 600-compound library application to forensic toxicology. Journal of Chromatography A, 1997.