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The binding of mutant p53 and DAB2IP increase the invasion of inflammation induced cancer cells

 

One of the important characteristics of cancer development is inflammation. However, due to the complex relationship between signaling molecules, the mechanism of how inflammation is linked to cancer is not very clear. Minin et al. inflammatory cytokines can increase the invasive behavior of cancer cells with p53 missense mutants (mutp53). The article was published on Molecular Cell, recently.

 

The mutation of p53, as a tumor suppressor, is always happened in cancer. Therefore, mutp53 is an important target for cancer study, and it is reported to drive inflammation induced cancer formation and development, in previous and this study, respectively. The action that inflammatory cytokine can increase aggressiveness of mutp53 cancer cell is assisted by chemokines. Further investigation of the mechanism showed mutp53 supported NF-κB signaling activation and reduce the activity of ASK1/JNK signaling by TNFα. Mutp53 functions through interacting and inhibiting the tumor suppressor RasGAP Disabled 2 Interacting Protein (DAB2IP). Moreover, the interference of the binding of mutp53-DAB2IP reduce the invasion of cancer cells in xenografts ,indicating mutp53/DAB2IP might be a promising target in therapy of mutp53 cancers.

 

Reference:
Mol Cell. 2014 Dec 4;56(5):617-29.

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